Extraskeletal osteosarcoma arising in the subcutaneous tissue of the lower leg: A case report and literature review

Tamura,Takashi; Suzuki,Kayo; Yasuda,Taketoshi; Nogami,Shigeharu; Watanabe,Kenta; Kanamori,Masahiko; Kimura,Tomoatsu

doi:10.3892/mco.2018.1662

September-2018 Volume 9 Issue 3

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

September-2018 Volume 9 Issue 3

Full Size Image

Case Report

Extraskeletal osteosarcoma arising in the subcutaneous tissue of the lower leg: A case report and literature review

Authors:
- Takashi Tamura
- Kayo Suzuki
- Taketoshi Yasuda
- Shigeharu Nogami
- Kenta Watanabe
- Masahiko Kanamori
- Tomoatsu Kimura
View Affiliations / Copyright

Affiliations: Department of Orthopaedic Surgery, Toyama Red Cross Hospital, Toyama, Toyama 930-0859, Japan, Department of Orthopaedic Surgery, University of Toyama, Toyama, Toyama 930-0194, Japan, Department of Orthopaedic Surgery, Takaoka City Hospital, Takaoka, Toyama 933-8550, Japan, Department of Human Science 1, University of Toyama, Toyama, Toyama 930-0194, Japan
Pages: 287-292
|
Published online on: June 26, 2018

https://doi.org/10.3892/mco.2018.1662
Expand metrics +

Abstract

Extraskeletal osteosarcoma (ESOS) is a rare soft tissue sarcoma accounting for 1-2% of all soft tissue sarcomas. ESOS originating in the superficial (cutaneous-subcutaneous) tissue is extremely rare, and only 17 cases with subcutaneous ESOS have been reported in detail to date. The aim of the present study was to report an additional case of subcutaneous ESOS of the lower leg and review previous reports of subcutaneous ESOS, focusing on the clinical characteristics, including the MIB-1 labeling index, treatment methods and outcomes. A 79-year-old healthy man presented with a 3-year history of a painful, slowly growing mass in his right lower leg that measured ~5 cm in greatest dimension. Excisional biopsy was performed, and ESOS was diagnosed based on the histopathological findings. A wide resection was performed when local recurrence developed. Six months after the wide resection, lung metastasis was detected. Considering the patient's age, stereotactic radiotherapy was performed without chemotherapy. The patient showed no evidence of local recurrence or new distant metastases for 2 years after the second surgery. We herein present this case of subcutaneous ESOS and review the previous 17 reported cases of subcutaneous ESOS. The 5-year survival rate of patients with subcutaneous ESOS was 78.6%, which was better compared with that of ESOS cases arising in deep soft tissue. Therefore, patients with subcutaneous ESOS may have a better prognosis compared with those with deep-seated ESOS, although the mean MIB-1 labeling index of subcutaneous ESOS was 24%.

View Figures

View References

1	Rosenberg AE: Extraskeletal osteosarcomaWHO classification of tumours of soft tissue and bone. Fletcher CDM, Bridge JA, Hogendoorn PCW and Mertens F: IARC; Lyon: pp. 161–162. 2013
2	Chung EB and Enzinger FM: Extraskeletal osteosarcoma. Cancer. 60:1132–1142. 1987. View Article : Google Scholar : PubMed/NCBI
3	Nakamura T, Matsumine A, Nishimura K, Yokoyama H, Murata T, Uchida A and Sudo A: Extraskeletal subcutaneous osteosarcoma of the upper arm: A case report. Oncol Lett. 2:75–77. 2011. View Article : Google Scholar : PubMed/NCBI
4	Thampi S, Matthay KK, Boscardin WJ, Goldsby R and DuBois SG: Clinical features and outcomes differ between skeletal and extraskeletal osteosarcoma. Sarcoma. 2014:9026202014. View Article : Google Scholar : PubMed/NCBI
5	Fang Z, Yokoyama R, Mukai K, Beppu Y and Fukuma H: Extraskeletal osteosarcoma: A clinicopathologic study of four cases. Jpn J Clin Oncol. 25:55–60. 1995.PubMed/NCBI
6	Jensen Lidang M, Schumacher B, Jensen Myhre O, Nielsen Steen O and Keller J: Extraskeletal osteosarcomas: A clinicopathologic study of 25 cases. Am J Surg Pathol. 22:588–594. 1998. View Article : Google Scholar : PubMed/NCBI
7	Dubec JJ, Munk PL, O'Connell JX, Lee MJ, Janzen D, Connell D, Masri B and Logan PM: Soft tissue osteosarcoma with telangiectatic features: MR imaging findings in two cases. Skeletal Radiol. 26:732–736. 1997. View Article : Google Scholar : PubMed/NCBI
8	Oonuma M, Hatori M, Hosaka M and Kokubun S: Extraskeletal osteosarcoma arising in the buttock. Ups J Med Sci. 106:211–215. 2001. View Article : Google Scholar : PubMed/NCBI
9	Hatano H, Morita T, Kobayashi H, Ito T, Segawa H and Hasegawa S: Extraskeletal osteosarcoma of the jaw. Skeletal Radiol. 34:171–175. 2005. View Article : Google Scholar : PubMed/NCBI
10	Papachristou DJ, Goodman M, Cieply K and Rao UN: Extraskeletal osteosarcoma of subcutaneous soft tissue with lymph node and skin metastasis: A case report with fluorescence in situ hybridization analysis. Pathol Oncol Res. 18:107–110. 2012. View Article : Google Scholar : PubMed/NCBI
11	Sarsilmaz A, Argin M, Sezak M, Altay C and Erdogan N: Primary osteosarcoma arising from subcutaneous tissue: 5-year follow-up. Clin Imaging. 36:402–405. 2012. View Article : Google Scholar : PubMed/NCBI
12	Zreik RT, Meyer RG, Jenkins RB, Norambuena GA and Fritchie KJ: A rare pediatric example of subcutaneous extraskeletal osteosarcoma: A case report and review of the morphologic differential diagnosis. Am J Dermatopathol. 38:e44–e48. 2016. View Article : Google Scholar : PubMed/NCBI
13	Healy C, Kahn LB and Kenan S: Subcutaneous extraskeletal osteosarcoma of the forearm: A case report and review of the literature. Skeletal Radiol. 45:1307–1311. 2016. View Article : Google Scholar : PubMed/NCBI
14	Longhi A, Bielack SS, Grimer R, Whelan J, Windhager R, Leithner A, Gronchi A, Biau D, Jutte P, Krieg AH, et al: Extraskeletal osteosarcoma: A European Musculoskeletal Oncology Society study on 266 patients. Eur J Cancer. 74:9–16. 2017. View Article : Google Scholar : PubMed/NCBI
15	Fan Z, Patel S, Lewis VO, Guadagnolo BA and Lin PP: Should high-grade extraosseous osteosarcoma be treated with multimodality therapy like other soft tissue sarcomas? Clin Orthop Relat Res. 473:3604–3611. 2015. View Article : Google Scholar : PubMed/NCBI
16	Choi LE, Healey JH, Kuk D and Brennan MF: Analysis of outcomes in extraskeletal osteosarcoma: A review of fifty-three cases. J Bone Joint Surg Am. 96(e2): 1–8. 2014.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Extraskeletal osteosarcoma arising in the subcutaneous tissue of the lower leg: A case report and literature review

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Related Articles