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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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September-2018 Volume 9 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Case Report

Treatment response to osimertinib in a patient with leptomeningeal metastasis from lung adenocarcinoma following failure of gefitinib and erlotinib: A case report

  • Authors:
    • Junjun Li
    • Xiaomei Liu
    • Caijun Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China
  • Pages: 321-324
    |
    Published online on: July 5, 2018
       https://doi.org/10.3892/mco.2018.1666
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Abstract

Epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs) are effective in the treatment of advanced non‑small‑cell lung cancer (NSCLC) with leptomeningeal metastases (LM); however, a proportion of the patients with resistant tumors do not benefit from EGFR‑TKI treatment. In the present study the case of a female patient with advanced lung adenocarcinoma harboring the EGFR L858R mutation (encoded in exon 21) who developed intracranial metastases following treatment with erlotinib after gefitinib failure is reported. The patient achieved a partial response (PR) after four cycles of chemotherapy with pemetrexed/cisplatin. However, after 4 months, LM were detected. The patient was treated with osimertinib, a third‑generation EGFR‑TKI, but the LM continued to progress and the patient eventually succumbed to the disease (overall survival, 6 months). Therefore, LM in patients without the EGFR T790M mutation (encoded in exon 20) appear to be resistant to treatment with the third‑generation TKI osimertinib, which may be associated with human epidermal growth factor receptor 2 amplification. Further clinical trials are required to confirm our results.
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Copy and paste a formatted citation
Spandidos Publications style
Li J, Liu X and Yuan C: Treatment response to osimertinib in a patient with leptomeningeal metastasis from lung adenocarcinoma following failure of gefitinib and erlotinib: A case report. Mol Clin Oncol 9: 321-324, 2018.
APA
Li, J., Liu, X., & Yuan, C. (2018). Treatment response to osimertinib in a patient with leptomeningeal metastasis from lung adenocarcinoma following failure of gefitinib and erlotinib: A case report. Molecular and Clinical Oncology, 9, 321-324. https://doi.org/10.3892/mco.2018.1666
MLA
Li, J., Liu, X., Yuan, C."Treatment response to osimertinib in a patient with leptomeningeal metastasis from lung adenocarcinoma following failure of gefitinib and erlotinib: A case report". Molecular and Clinical Oncology 9.3 (2018): 321-324.
Chicago
Li, J., Liu, X., Yuan, C."Treatment response to osimertinib in a patient with leptomeningeal metastasis from lung adenocarcinoma following failure of gefitinib and erlotinib: A case report". Molecular and Clinical Oncology 9, no. 3 (2018): 321-324. https://doi.org/10.3892/mco.2018.1666
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Liu X and Yuan C: Treatment response to osimertinib in a patient with leptomeningeal metastasis from lung adenocarcinoma following failure of gefitinib and erlotinib: A case report. Mol Clin Oncol 9: 321-324, 2018.
APA
Li, J., Liu, X., & Yuan, C. (2018). Treatment response to osimertinib in a patient with leptomeningeal metastasis from lung adenocarcinoma following failure of gefitinib and erlotinib: A case report. Molecular and Clinical Oncology, 9, 321-324. https://doi.org/10.3892/mco.2018.1666
MLA
Li, J., Liu, X., Yuan, C."Treatment response to osimertinib in a patient with leptomeningeal metastasis from lung adenocarcinoma following failure of gefitinib and erlotinib: A case report". Molecular and Clinical Oncology 9.3 (2018): 321-324.
Chicago
Li, J., Liu, X., Yuan, C."Treatment response to osimertinib in a patient with leptomeningeal metastasis from lung adenocarcinoma following failure of gefitinib and erlotinib: A case report". Molecular and Clinical Oncology 9, no. 3 (2018): 321-324. https://doi.org/10.3892/mco.2018.1666
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