Local recurrence of T1a rectal cancer following radical endoscopic mucosal resection: A case report

Matsumoto,Keita; Matsuhashi,Nobuhisa; Takahashi,Takao; Tanahashi,Toshiyuki; Matsui,Satoshi; Suetsugu,Tomonari; Tajima,Jesse Yu; Imai,Takeharu; Imai,Hisashi; Tanaka,Yoshihiro; Yamaguchi,Kazuya; Suzui,Natsuko; Miyazaki,Tatsuhiko; Yoshida,Kazuhiro

doi:10.3892/mco.2018.1667

September-2018 Volume 9 Issue 3

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

September-2018 Volume 9 Issue 3

Full Size Image

Case Report Open Access

Local recurrence of T1a rectal cancer following radical endoscopic mucosal resection: A case report

Authors:
- Keita Matsumoto
- Nobuhisa Matsuhashi
- Takao Takahashi
- Toshiyuki Tanahashi
- Satoshi Matsui
- Tomonari Suetsugu
- Jesse Yu Tajima
- Takeharu Imai
- Hisashi Imai
- Yoshihiro Tanaka
- Kazuya Yamaguchi
- Natsuko Suzui
- Tatsuhiko Miyazaki
- Kazuhiro Yoshida
View Affiliations / Copyright

Affiliations: Department of Surgical Oncology, Gifu University School of Medicine, Gifu, Gifu 501-1194, Japan, Pathology Division, Gifu University School of Medicine, Gifu, Gifu 501-1194, Japan

Copyright: © Matsumoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 305-309
|
Published online on: July 5, 2018

https://doi.org/10.3892/mco.2018.1667
Expand metrics +

Abstract

We herein report a case of local recurrence of T1a rectal cancer following radical endoscopic mucosal resection (EMR). A 63-year-old man underwent EMR for a 0-IIa lesion of the Ra portion of the rectum. The findings on pathological examination were tub1, T1a (sm1, 420 µm), ly0 and v0, and the EMR had been considered a transitional procedure. Colonoscopy performed 26 months after EMR revealed a submucosal tumor (SMT) near the EMR scar in the left wall of the Ra portion of the rectum. An abdominal enhanced computed tomography scan revealed infiltration of the thickness of the wall with limited extramural extension, and a lymph node 10 mm in diameter. Endoscopic ultrasound-guided fine-needle aspiration also indicated a SMT on the left side of the Ra portion of the rectum that extended from the submucosal layer to beyond the serosal layer, and a lymph node sized 17x11 mm to the left of the Ra portion near the oral side 2 cm from the SMT. The pathological findings confirmed the SMT to be an adenocarcinoma with a metastatic lymph node. Local and lymph node recurrence of rectal cancer following radical EMR was diagnosed, and laparoscopic ultra-low anterior resection, D3 lymph node dissection and a diverting ileostomy were performed. The pathological findings of the excised specimen were T3 (A/SS), ly0, v3, PN1b, pPM0, pDM0, pRM0 (100 µm) and pN0 (0/15). XELOX therapy was administered for 6 months postoperatively as adjuvant chemotherapy, and there has been no recurrence during the first 12 months of follow-up.

View Figures

View References

1	Watanabe T, Muro K, Ajioka Y, Hashiguchi Y, Ito Y, Saito Y, Hamaguchi T, Ishida H, Ishiguro M, Ishihara S, Kanemitsu Y, et al Japanese Society for Cancer of the Colon and Rectum, : Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer. Int J Clin Oncol. 23:1–34. 2018. View Article : Google Scholar : PubMed/NCBI
2	Tamegai Y, Fukunaga Y, Chino A, Taniguchi C, Suzuki S, Morishige K, et al: Progress of Endoscopic Treatment for Early Colorectal Cancers. J Jpn Soc Coloproctol. 65:800–807. 2012. View Article : Google Scholar
3	Tajika M, Niwa Y, Bhatia V, Kondo S, Tanaka T, Mizuno N, Hara K, Hijioka S, Imaoka H, Ogura T, et al: Comparison of endoscopic submucosal dissection and endoscopic mucosal resection for large colorectal tumors. Eur J Gastroenterol Hepatol. 23:1042–1049. 2011.PubMed/NCBI
4	Tanaka N, Igarashi M, Kobayashi K, Sano Y, Saito Y, Yamamoto H, et al: Surveillance of colorectal cancer after endoscopic treatment. Colon Dis. 2007:112–120. 2007.(In Japanese).
5	Kuroda Y, Takayama Y, Matsumoto S, Teraji T, Tahara K, Saeki K, et al: A resected case of local progressive sigmoid colon carcinoma after radial endoscopic mucosal resection for SM1 carcinoma. Clin Res. 90:127–305. 2013.(In Japanese).
6	Kobayashi H, Ikegami M, Mitobe J and Urashima M: Risk Factor for Lymph Node Metastasis of Colorectal Carcinomas with Submucosal Invasion. Tokyo Jikeikai Med J. 124:113–126. 2009.
7	Taniguchi H, Fukazawa Y, Sekine S, Shimoda T and Kushima R: Vascular Infiltration of Submucosal Invasive Colorectal Cancer. Stomach Intestine Tokyo. 44:1241–1248. 2009.
8	Matsubara A, Kushima R, Taniguchi H and Sekine S: Special Stains Useful for Diagnosis of Colon Tumors. Stomach Intestine Tokyo. 45:699–704. 2010.
9	Nikami T, Saito S, Ishii H, Kobayashi H, Mitobe J, Aihara H, et al: Risk Factors for Lymph Node Metastasis of Submucosal Invasive Colon Cancer-Emphasis on Detection of Vessel Permeation Using Special Stains. Stomach Intestine Tokyo. 46:1459–1468. 2011.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Local recurrence of T1a rectal cancer following radical endoscopic mucosal resection: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Related Articles