Abscopal effect following radiation monotherapy in breast cancer: A case report

Azami,Ayaka; Suzuki,Nobuyasu; Azami,Yusuke; Seto,Ichiro; Sato,Atai; Takano,Yoshinao; Abe,Tsuyoshi; Teranishi,Yasushi; Tachibana,Kazunoshin; Ohtake,Tohru

doi:10.3892/mco.2018.1677

September-2018 Volume 9 Issue 3

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September-2018 Volume 9 Issue 3

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Case Report

Abscopal effect following radiation monotherapy in breast cancer: A case report

Authors:
- Ayaka Azami
- Nobuyasu Suzuki
- Yusuke Azami
- Ichiro Seto
- Atai Sato
- Yoshinao Takano
- Tsuyoshi Abe
- Yasushi Teranishi
- Kazunoshin Tachibana
- Tohru Ohtake
View Affiliations / Copyright

Affiliations: Department of Surgery, Southern Tohoku Research Institute for Neuroscience, Southern Tohoku General Hospital, Koriyama, Fukushima 963-8563. Japan, Department of Radiation Therapy, Southern Tohoku Research Institute for Neuroscience, Southern Tohoku General Hospital, Koriyama, Fukushima 963-8563. Japan, Department of Breast Surgery, Fukushima Medical University School of Medicine, Fukushima, Fukushima 960-1295, Japan
Pages: 283-286
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Published online on: July 19, 2018

https://doi.org/10.3892/mco.2018.1677
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Abstract

Radiotherapy has been found to be valuable for the control and eradication of local foci in various malignant tumors. The abscopal effect is determined as a systemic antitumor response at a distance from the irradiation site invoked by local irradiation. We herein present an extremely rare case of breast cancer in a 64-year-old woman, in whom the abscopal effect was observed after radiotherapy induced an antitumor response in all metastatic lesions, without any combination therapy. The patient was admitted to our hospital complaining of a breast mass and pain at the left hip, and was diagnosed with breast cancer with multiple bone, lung and lymph node metastases. She received treatment with local radiotherapy delivered to the breast tumor and some of the bone metastases but did not receive chemotherapy due to her poor performance status. However, 10 months after radiotherapy, spontaneous regression was observed, not only within the irradiated field, but also in the non-irradiated areas. All signs of cancer throughout the body disappeared, and the patient's performance status drastically improved. To the best of our knowledge, there have been no reports of advanced breast cancer cases in which the abscopal effect was observed after radiation monotherapy; therefore, this case report is extremely rare and highly valuable.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Abscopal effect following radiation monotherapy in breast cancer: A case report

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