Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
September-2018 Volume 9 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 9 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

5‑HT serotonin receptors modulate mitogenic signaling and impact tumor cell viability

  • Authors:
    • Yessenia Ballou
    • Alexandria Rivas
    • Andres Belmont
    • Luv Patel
    • Clarissa N. Amaya
    • Shane Lipson
    • Thuraieh Khayou
    • Erin B. Dickerson
    • Zeina Nahleh
    • Brad A. Bryan
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Sciences, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA, Department of Veterinary Clinical Sciences, University of Minnesota, Saint Paul, MN 55108, USA
    Copyright: © Ballou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 243-254
    |
    Published online on: July 19, 2018
       https://doi.org/10.3892/mco.2018.1681
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Symptoms of depression are present in over half of all cancer patients, and selective serotonin reuptake inhibitor (SSRI) anti‑depressant medications are prescribed to nearly a quarter of these individuals in order to cope with their disease. Previous studies have provided evidence that elevated serotonin (5‑HT) and serotonin receptor levels may contribute to oncogenic progression, yet little is known regarding the mechanism by which this occurs. The data demonstrated that serotonin receptor mRNAs and proteins are expressed across diverse cancer types, and that serotonin stimulation of tumor cells activates oncogenic signaling mediators including components of the AKT, CREB, GSK3, and MAPK pathways. Selective pharmacological inhibition of the seven known classes of 5‑HT receptors in sarcoma and breast cancer cells resulted in dose dependent decreases in tumor cell viability, activation of the p53 DNA damage pathway, suppression of MAPK activity, and significantly reduced tumor volume in an in ovo model. Based on a retrospective clinical analysis of 419 patients diagnosed with breast cancer, we discovered that use of SSRIs was associated with a 2.3‑fold increase in tumor proliferation rates for late stage patients based on their Ki‑67 index (P=0.03). These data provide evidence that serotonin signaling pathways, which treating oncologists often pharmacologically target to assist cancer patients to psychologically cope with their illness, activate signaling pathways known to promote tumor growth and survival.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Sanjida S, Janda M, Kissane D, Shaw J, Pearson SA, DiSipio T and Couper J: A systematic review and meta-analysis of prescribing practices of antidepressants in cancer patients. Psychooncology. 25:1002–1016. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Collet C, Schiltz C, Geoffroy V, Maroteaux L, Launay JM and de Vernejoul MC: The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation. FASEB J. 22:418–427. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Fanburg BL and Lee SL: A new role for an old molecule: Serotonin as a mitogen. Am J Physiol. 272:L795–L806. 1997.PubMed/NCBI

4 

Lesurtel M, Graf R, Aleil B, Walther DJ, Tian Y, Jochum W, Gachet C, Bader M and Clavien PA: Platelet-derived serotonin mediates liver regeneration. Science. 312:104–107. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS and Garnovskaya MN: Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacol Ther. 92:179–212. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Christensen DK, Armaiz-Pena GN, Ramirez E, Matsuo K, Zimmerman B, Zand B, Shinn E, Goodheart MJ, Bender D, Thaker PH, et al: SSRI use and clinical outcomes in epithelial ovarian cancer. Oncotarget. 7:33179–33191. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Fatima S, Shi X, Lin Z, Chen GQ, Pan XH, Wu JC, Ho JW, Lee NP, Gao H, Zhang G, et al: 5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin. Mol Oncol. 10:195–212. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Gautam J, Bae YK and Kim JA: Up-regulation of cathepsin S expression by HSP90 and 5-HT7 receptor-dependent serotonin signaling correlates with triple negativity of human breast cancer. Breast Cancer Res. 161:29–40. 2017. View Article : Google Scholar

9 

Jiang SH, Li J, Dong FY, Yang JY, Liu DJ, Yang XM, Wang YH, Yang MW, Fu XL, Zhang XX, et al: Increased serotonin signaling contributes to the warburg effect in pancreatic tumor cells under metabolic stress and promotes growth of pancreatic tumors in mice. Gastroenterology. 153:277–291. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Kubera M, Grygier B, Wrona D, Rogóż Z, Roman A, Basta-Kaim A, Budziszewska B, Leskiewicz M, Jantas D, Nowak W, et al: Stimulatory effect of antidepressant drug pretreatment on progression of B16F10 melanoma in high-active male and female C57BL/6J mice. J Neuroimmunol 240-241. 1–44. 2011.

11 

Liang C, Chen W, Zhi X, Ma T, Xia X, Liu H, Zhang Q, Hu Q, Zhang Y, Bai X and Liang T: Serotonin promotes the proliferation of serum-deprived hepatocellular carcinoma cells via upregulation of FOXO3a. Mol Cancer. 12:142013. View Article : Google Scholar : PubMed/NCBI

12 

Peters MA, Walenkamp AM, Kema IP, Meijer C, de Vries EG and Oosting SF: Dopamine and serotonin regulate tumor behavior by affecting angiogenesis. Drug Resist Updat. 17:96–104. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Sarrouilhe D, Clarhaut J, Defamie N and Mesnil M: Serotonin and cancer: What is the link? Curr Mol Med. 15:62–77. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Siddiqui EJ, Shabbir M, Mikhailidis DP, Thompson CS and Mumtaz FH: The role of serotonin (5-hydroxytryptamine1A and 1B) receptors in prostate cancer cell proliferation. J Urol. 176:1648–1653. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Siddiqui EJ, Shabbir MA, Mikhailidis DP, Mumtaz FH and Thompson CS: The effect of serotonin and serotonin antagonists on bladder cancer cell proliferation. BJU Int. 97:634–639. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Siddiqui EJ, Thompson CS, Mikhailidis DP and Mumtaz FH: The role of serotonin in tumour growth (review). Oncol Rep. 14:1593–1597. 2005.PubMed/NCBI

17 

Sui H, Xu H, Ji Q, Liu X, Zhou L, Song H, Zhou X, Xu Y, Chen Z, Cai J, et al: 5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/β-catenin/MMP-7 signaling pathway. Oncotarget. 6:25975–25987. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Vicaut E, Laemmel E and Stucker O: Impact of serotonin on tumour growth. Ann Med. 32:187–194. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Zong JC, Wang X, Zhou X, Wang C, Chen L, Yin LJ, He BC and Deng ZL: Gut-derived serotonin induced by depression promotes breast cancer bone metastasis through the RUNX2/PTHrP/RANKL pathway in mice. Oncol Rep. 35:739–748. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Julius D, Huang KN, Livelli TJ, Axel R and Jessell TM: The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors. Proc Natl Acad Sci USA. 87:928–932. 1990. View Article : Google Scholar : PubMed/NCBI

21 

Julius D, Livelli TJ, Jessell TM and Axel R: Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation. Science. 244:1057–1062. 1989. View Article : Google Scholar : PubMed/NCBI

22 

Jungwirth N, Haeberle L, Schrott KM, Wullich B and Krause FS: Serotonin used as prognostic marker of urological tumors. World J Urol. 26:499–504. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Dizeyi N, Bjartell A, Nilsson E, Hansson J, Gadaleanu V, Cross N and Abrahamsson PA: Expression of serotonin receptors and role of serotonin in human prostate cancer tissue and cell lines. Prostate. 59:328–336. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Launay JM, Birraux G, Bondoux D, Callebert J, Choi DS, Loric S and Maroteaux L: Ras involvement in signal transduction by the serotonin 5-HT2B receptor. J Biol Chem. 271:3141–3147. 1996. View Article : Google Scholar : PubMed/NCBI

25 

Dizeyi N, Bjartell A, Hedlund P, Tasken KA, Gadaleanu V and Abrahamsson PA: Expression of serotonin receptors 2B and 4 in human prostate cancer tissue and effects of their antagonists on prostate cancer cell lines. Eur Urol. 47:895–900. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Dizeyi N, Hedlund P, Bjartell A, Tinzl M, Austild-Tasken K and Abrahamsson PA: Serotonin activates MAP kinase and PI3K/Akt signaling pathways in prostate cancer cell lines. Urol Oncol. 29:436–445. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, et al: The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 483:603–607. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Modiano JF: Comparative pathogenesis of cancers in animals and humans. Vet Sci. 3:2016.PubMed/NCBI

29 

Stiles JM, Amaya C, Rains S, Diaz D, Pham R, Battiste J, Modiano JF, Kokta V, Boucheron LE, Mitchell DC and Bryan BA: Targeting of beta adrenergic receptors results in therapeutic efficacy against models of hemangioendothelioma and angiosarcoma. PLoS One. 8:e600212013. View Article : Google Scholar : PubMed/NCBI

30 

Spencer C, Montalvo J, McLaughlin SR and Bryan BA: Small molecule inhibition of cytoskeletal dynamics in melanoma tumors results in altered transcriptional expression patterns of key genes involved in tumor initiation and progression. Cancer Genomics Proteomics. 8:77–85. 2011.PubMed/NCBI

31 

Gautam J, Banskota S, Regmi SC, Ahn S, Jeon YH, Jeong H, Kim SJ, Nam TG, Jeong BS and Kim JA: Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer. 15:752016. View Article : Google Scholar : PubMed/NCBI

32 

Gurbuz N, Asoglu MR, Ashour AA, Salama S, Kilic GS and Ozpolat B: A selective serotonin 5-HT1B receptor inhibition suppresses cells proliferation and induces apoptosis in human uterine leiomyoma cells. Eur J Obstet Gynecol Reprod Biol. 206:114–119. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Gwynne WD, Hallett RM, Girgis-Gabardo A, Bojovic B, Dvorkin-Gheva A, Aarts C, Dias K, Bane A and Hassell JA: Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts. Oncotarget. 8:32101–32116. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Hejazi SH, Ahangari G and Deezagi A: Alternative Viewpoint Against Breast Cancer Based on Selective Serotonin Receptors 5HTR3A and 5HTR2A Antagonists that can Mediate Apoptosis in MCF-7 Cell Line. Curr Drug Discov Technol. 12:240–249. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Abdel-Hamid NM, Shehata DE, Abdel-Ghany AA, Ragaa A and Wahid A: Serum serotonin as unexpected potential marker for staging of experimental hepatocellular carcinoma. Biomed Pharmacother. 83:407–411. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Kourtidis A, Lu R, Pence LJ and Anastasiadis PZ: A central role for cadherin signaling in cancer. Exp Cell Res. 358:78–85. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Leoncikas V, Wu H, Ward LT, Kierzek AM and Plant NJ: Generation of 2,000 breast cancer metabolic landscapes reveals a poor prognosis group with active serotonin production. Sci Rep. 6:197712016. View Article : Google Scholar : PubMed/NCBI

38 

Asada M, Ebihara S, Yamanda S, Niu K, Okazaki T, Sora I and Arai H: Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation. Neoplasia. 11:408–417. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Banskota S, Gautam J, Regmi SC, Gurung P, Park MH, Kim SJ, Nam TG, Jeong BS and Kim JA: BJ-1108, a 6-amino-2,4,5-trimethylpyridin-3-ol analog, inhibits serotonin-induced angiogenesis and tumor growth through PI3K/NOX pathway. PLoS One. 11:e01481332016. View Article : Google Scholar : PubMed/NCBI

40 

Cattaneo MG, Palazzi E, Bondiolotti G and Vicentini LM: 5-HT1D receptor type is involved in stimulation of cell proliferation by serotonin in human small cell lung carcinoma. Eur J Pharmacol. 268:425–430. 1994. View Article : Google Scholar : PubMed/NCBI

41 

Ataee R, Ajdary S, Zarrindast M, Rezayat M, Shokrgozar MA and Ataee A: Y25130 hydrochloride, a selective 5HT3 receptor antagonist has potent antimitogenic and apoptotic effect on HT29 colorectal cancer cell line. Eur J Cancer Prev. 19:138–143. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Engel M, Smidt MP and van Hooft JA: The serotonin 5-HT3 receptor: A novel neurodevelopmental target. Front Cell Neurosci. 7:762013. View Article : Google Scholar : PubMed/NCBI

43 

Cosgrove L, Shi L, Creasey DE, Anaya-McKivergan M, Myers JA and Huybrechts KF: Antidepressants and breast and ovarian cancer risk: A review of the literature and researchers' financial associations with industry. PLoS One. 6:e182102011. View Article : Google Scholar : PubMed/NCBI

44 

Chung CM, Kuo TM, Chiang SL, Wang ZH, Hung CC, Lane HY, Liu CS and Ko YC: Antidepressants in association with reducing risk of oral cancer occurrence: A nationwide population-based cohort and nested case-control studies. Oncotarget. 7:11687–11695. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Hsieh YH, Chiu WC, Lin CF, Chan HL, Liang HY, Lee Y, McIntyre RS and Chen VC: Antidepressants and gastric cancer: A nationwide population-based nested case-control study. PLoS One. 10:e01436682015. View Article : Google Scholar : PubMed/NCBI

46 

Chan HL, Hsieh YH, Lin CF, Liang HY, Huang KY, Chiu WC, Lee Y, McIntyre RS and Chen VC: Invasive cervical cancer and antidepressants: A nationwide population-based study. Medicine. 94:e18662015. View Article : Google Scholar : PubMed/NCBI

47 

Lee HC, Chiu WC, Wang TN, Liao YT, Chien IC, Lee Y, McIntyre RS, Chen PC and Chen VC: Antidepressants and colorectal cancer: A population-based nested case-control study. J Affect Disord. 207:353–358. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Caudill JS, Brown PD, Cerhan JH and Rummans TA: Selective serotonin reuptake inhibitors, glioblastoma multiforme and impact on toxicities and overall survival: The mayo clinic experience. Am J Clin Oncol. 34:385–387. 2011. View Article : Google Scholar : PubMed/NCBI

49 

Pocha C, Knott A, Rector TS and Dieperink E: Are selective serotonin reuptake inhibitors associated with hepatocellular carcinoma in patients with hepatitis C? J Clin Psychiatry. 75:e1122–e1126. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Boursi B, Lurie I, Haynes K, Mamtani R and Yang YX: Chronic therapy with selective serotonin reuptake inhibitors and survival in newly diagnosed cancer patients. Eur J Cancer Care(Engl). 27:e126662018. View Article : Google Scholar

51 

Boursi B, Lurie I, Mamtani R, Haynes K and Yang YX: Anti-depressant therapy and cancer risk: A nested case-control study. Eur Neuropsychopharmacol. 25:1147–1157. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Haukka J, Sankila R, Klaukka T, Lonnqvist J, Niskanen L, Tanskanen A, Wahlbeck K and Tiihonen J: Incidence of cancer and antidepressant medication: Record linkage study. Int J Cancer. 126:285–296. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Xu W, Tamim H, Shapiro S, Stang MR and Collet JP: Use of antidepressants and risk of colorectal cancer: A nested case-control study. Lancet Oncol. 7:301–308. 2006. View Article : Google Scholar : PubMed/NCBI

54 

Brandes LJ, Arron RJ, Bogdanovic RP, Tong J, Zaborniak CL, Hogg GR, Warrington RC, Fang W and LaBella FS: Stimulation of malignant growth in rodents by antidepressant drugs at clinically relevant doses. Cancer Res. 52:3796–3800. 1992.PubMed/NCBI

55 

Montoya A, Amaya CN, Belmont A, Diab N, Trevino R, Villanueva G, Rains S, Sanchez LA, Badri N, Otoukesh S, et al: Use of non-selective β-blockers is associated with decreased tumor proliferative indices in early stage breast cancer. Oncotarget. 8:6446–6460. 2017. View Article : Google Scholar : PubMed/NCBI

56 

Thaker PH, Han LY, Kamat AA, Arevalo JM, Takahashi R, Lu C, Jennings NB, Armaiz-Pena G, Bankson JA, Ravoori M, et al: Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med. 12:939–944. 2006. View Article : Google Scholar : PubMed/NCBI

57 

Watkins JL, Thaker PH, Nick AM, Ramondetta LM, Kumar S, Urbauer DL, Matsuo K, Squires KC, Coleman RL, Lutgendorf SK, et al: Clinical impact of selective and nonselective beta-blockers on survival in patients with ovarian cancer. Cancer. 121:3444–3451. 2015. View Article : Google Scholar : PubMed/NCBI

58 

Leaute-Labreze C, Hoeger P, Mazereeuw-Hautier J, Guibaud L, Baselga E, Posiunas G, Phillips RJ, Caceres H, Lopez Gutierrez JC, Ballona R, et al: A randomized, controlled trial of oral propranolol in infantile hemangioma. N Engl J Med. 372:735–746. 2015. View Article : Google Scholar : PubMed/NCBI

59 

Leaute-Labreze C and Taieb A: Efficacy of beta-blockers in infantile capillary haemangiomas: The physiopathological significance and therapeutic consequences. Ann Dermatol Venereol. 135:860–862. 2008. View Article : Google Scholar : PubMed/NCBI

60 

Banavali S, Pasquier E and Andre N: Targeted therapy with propranolol and metronomic chemotherapy combination: Sustained complete response of a relapsing metastatic angiosarcoma. Ecancermedicalscience. 9:4992015. View Article : Google Scholar : PubMed/NCBI

61 

Chow W, Amaya CN, Rains S, Chow M, Dickerson EB and Bryan BA: Growth attenuation of cutaneous angiosarcoma with propranolol-mediated β-blockade. JAMA Dermatol. 151:1226–1229. 2015. View Article : Google Scholar : PubMed/NCBI

62 

Daguze J, Saint-Jean M, Peuvrel L, Cassagnau E, Quéreux G, Khammari A and Dréno B: Visceral metastatic angiosarcoma treated effectively with oral cyclophosphamide combined with propranolol. JAAD Case Rep. 2:497–499. 2016. View Article : Google Scholar : PubMed/NCBI

63 

Pasquier E, Andre N, Street J, Chougule A, Rekhi B, Ghosh J, Philip DSJ, Meurer M, MacKenzie KL, Kavallaris M and Banavali SD: Effective management of advanced angiosarcoma by the synergistic combination of propranolol and vinblastine-based metronomic chemotherapy: A bench to bedside study. EBioMedicine. 6:87–95. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ballou Y, Rivas A, Belmont A, Patel L, Amaya CN, Lipson S, Khayou T, Dickerson EB, Nahleh Z, Bryan BA, Bryan BA, et al: 5‑HT serotonin receptors modulate mitogenic signaling and impact tumor cell viability. Mol Clin Oncol 9: 243-254, 2018.
APA
Ballou, Y., Rivas, A., Belmont, A., Patel, L., Amaya, C.N., Lipson, S. ... Bryan, B.A. (2018). 5‑HT serotonin receptors modulate mitogenic signaling and impact tumor cell viability. Molecular and Clinical Oncology, 9, 243-254. https://doi.org/10.3892/mco.2018.1681
MLA
Ballou, Y., Rivas, A., Belmont, A., Patel, L., Amaya, C. N., Lipson, S., Khayou, T., Dickerson, E. B., Nahleh, Z., Bryan, B. A."5‑HT serotonin receptors modulate mitogenic signaling and impact tumor cell viability". Molecular and Clinical Oncology 9.3 (2018): 243-254.
Chicago
Ballou, Y., Rivas, A., Belmont, A., Patel, L., Amaya, C. N., Lipson, S., Khayou, T., Dickerson, E. B., Nahleh, Z., Bryan, B. A."5‑HT serotonin receptors modulate mitogenic signaling and impact tumor cell viability". Molecular and Clinical Oncology 9, no. 3 (2018): 243-254. https://doi.org/10.3892/mco.2018.1681
Copy and paste a formatted citation
x
Spandidos Publications style
Ballou Y, Rivas A, Belmont A, Patel L, Amaya CN, Lipson S, Khayou T, Dickerson EB, Nahleh Z, Bryan BA, Bryan BA, et al: 5‑HT serotonin receptors modulate mitogenic signaling and impact tumor cell viability. Mol Clin Oncol 9: 243-254, 2018.
APA
Ballou, Y., Rivas, A., Belmont, A., Patel, L., Amaya, C.N., Lipson, S. ... Bryan, B.A. (2018). 5‑HT serotonin receptors modulate mitogenic signaling and impact tumor cell viability. Molecular and Clinical Oncology, 9, 243-254. https://doi.org/10.3892/mco.2018.1681
MLA
Ballou, Y., Rivas, A., Belmont, A., Patel, L., Amaya, C. N., Lipson, S., Khayou, T., Dickerson, E. B., Nahleh, Z., Bryan, B. A."5‑HT serotonin receptors modulate mitogenic signaling and impact tumor cell viability". Molecular and Clinical Oncology 9.3 (2018): 243-254.
Chicago
Ballou, Y., Rivas, A., Belmont, A., Patel, L., Amaya, C. N., Lipson, S., Khayou, T., Dickerson, E. B., Nahleh, Z., Bryan, B. A."5‑HT serotonin receptors modulate mitogenic signaling and impact tumor cell viability". Molecular and Clinical Oncology 9, no. 3 (2018): 243-254. https://doi.org/10.3892/mco.2018.1681
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team