Incidental discovery of mucinous adenocarcinoma of the prostate following transurethral resection of the prostate: A report of two cases and a literature review

Zhang,Lijie; Zhang,Lihua; Chen,Ming; Fang,Quan

doi:10.3892/mco.2018.1686

October-2018 Volume 9 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

October-2018 Volume 9 Issue 4

Full Size Image

Article

Incidental discovery of mucinous adenocarcinoma of the prostate following transurethral resection of the prostate: A report of two cases and a literature review

Authors:
- Lijie Zhang
- Lihua Zhang
- Ming Chen
- Quan Fang
View Affiliations / Copyright

Affiliations: Department of Urology, Zhongda Hospital, Southeast University College of Medicine, Nanjing, Jiangsu 210096, P.R. China, Department of Pathology, Zhongda Hospital, Southeast University College of Medicine, Nanjing, Jiangsu 210096, P.R. China
Pages: 432-436
|
Published online on: July 30, 2018

https://doi.org/10.3892/mco.2018.1686
Expand metrics +

Abstract

Mucinous carcinoma is an unusual subtype of prostate cancer. In particular, mucinous adenocarcinomas identified following transurethral resection of the prostate (TURP) are extremely rare. The present study conducted are retrospective analysis of two cases of mucinous carcinoma of the prostate, which were incidentally diagnosed following histological examination of the specimens obtained by TURP. The pathological findings, treatment regimen and clinical course of the two cases were reviewed. One of the patients, whose surgical specimen stained positive for carcinoembryonic antigen (CEA) and negative for prostate-specific antigen (PSA), did not respond to androgen deprivation therapy (ADT). However, the other patient, whose specimen stained positive for PSA, was responsive to ADT, resulting in a better prognosis. Therefore, absence of PSA staining in surgical prostate specimens may be associated with a poor response to ADT and a worse prognosis.

View Figures

View References

1	Epstein JI and Lieberman PH: Mucinous adenocarcinoma of the prostate gland. Am J Surg Pathol. 9:299–308. 1985. View Article : Google Scholar : PubMed/NCBI
2	Osunkoya AO and Epstein JI: Primary mucin-producing urothelial-type adenocarcinoma of prostate: Report of 15 cases. Am J Surg Pathol. 31:1323–1329. 2007. View Article : Google Scholar : PubMed/NCBI
3	Ro JY, Grignon DJ, Ayala AG, Fernandez PL, Ordonez NG and Wishnow KI: Mucinous adenocarcinoma of the prostate: Histochemical and immunohistochemical studies. Hum Pathol. 21:593–600. 1990. View Article : Google Scholar : PubMed/NCBI
4	Tombal B, De Visccher L, Cosyns JP, Lorge F, Opsomer R, Wese FX and Van Cangh PJ: Assessing the risk of unsuspected prostate cancer in patients with benign prostatic hypertrophy: A 13-year retrospective study of the incidence and natural history of T1a-T1b prostate cancers. BJU Int. 84:1015–1020. 1999. View Article : Google Scholar : PubMed/NCBI
5	Tran TA, Jennings TA, Ross JS and Nazeer T: Pseudomyxoma ovariilike posttherapeutic alteration in prostatic adenocarcinoma: A distinctive pattern in patients receiving neoadjuvant androgen ablation therapy. Am J Surg Pathol. 22:347–354. 1998. View Article : Google Scholar : PubMed/NCBI
6	Helpap B and Köllermann J: Undifferentiated carcinoma of the prostate with small cell features: Immunohistochemical subtyping and reflections on histogenesis. Virchows Arch. 434:385–391. 1999. View Article : Google Scholar : PubMed/NCBI
7	Bassily NH, Vallorosi CJ, Akdas G, Montie JE and Rubin MA: Coordinate expression of cytokeratins 7 and 20 in prostate adenocarcinoma and bladder urothelial carcinoma. Am J Clin Pathol. 113:383–388. 2000. View Article : Google Scholar : PubMed/NCBI
8	Furuta A, Naruoka T, Hasegawa N, Suzuki Y, Ikemoto I and Oishi Y: Mucinous adenocarcinoma of the prostate: A case report and review of 32 cases on immunohistochemical study of both PSA and CEA. Nippon Hinyokika Gakkai Zasshi. 94:570–573. 2003.(In Chinese). PubMed/NCBI
9	Rhee AC, Olgac S, Ohori M and Russo P: Mucinous adenocarcinoma of the prostate: A case report of long-term disease-free survival and a review of the literature. Urology. 63:779–780. 2004. View Article : Google Scholar : PubMed/NCBI
10	Osunkoya AO, Nielsen ME and Epstein JI: Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: A study of 47 cases. Am J Surg Pathol. 32:468–472. 2008. View Article : Google Scholar : PubMed/NCBI
11	Manne RK and Haddad FS: Mucinous adenocarcinoma of prostate. Urology. 33:247–249. 1989. View Article : Google Scholar : PubMed/NCBI