Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
November-2018 Volume 9 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2018 Volume 9 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Oncotype testing in patients undergoing intraoperative radiation for breast cancer

  • Authors:
    • Kelsey E. Larson
    • Stephanie A. Valente
    • Chirag Shah
    • Rahul D. Tendulkar
    • Sheen Cherian
    • Jame Abraham
    • Courtney Yanda
    • Chao Tu
    • Jessica Echle
    • Stephen R. Grobmyer
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Division of Breast Services, Cleveland Clinic, Cleveland, OH 44195, USA, Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH 44195, USA, Department of Medical Oncology, Cleveland Clinic, Cleveland, OH 44195, USA, Quantitative Health Science, Cleveland Clinic, Cleveland, OH 44195, USA
  • Pages: 535-538
    |
    Published online on: August 23, 2018
       https://doi.org/10.3892/mco.2018.1704
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oncotype DX recurrence score (RS) predicts risk of distant disease recurrence, and can guide chemotherapy recommendations in hormone positive, human epidermal growth factor 2‑negative, early stage breast cancer. The present study aimed to evaluate the pattern of oncotype testing, RS and adjuvant treatment in patients undergoing intraoperative radiotherapy (IORT). Single center prospective data registry was queried for patients receiving IORT between October 2011 and February 2017. Patient demographics, tumor characteristics, RS, systemic therapy and recurrence information were analyzed. A total of 150 women with mean age of 70.8 years were included. The majority had invasive ductal cancer (60.6%) with 1.0 cm average tumor size and no lymph node involvement (99%). Oncotype testing was performed in 36 patients (24.3%). Low risk score (<18) was confirmed in 19 women (53%); intermediate risk score (18‑30) in 16 women (44%); and high risk score (>30) in one woman (3%). Patients with RS testing had significantly increased tumor sizes (1.2 vs. 1.0 cm; P<0.001) and were younger (68.5 vs. 71.3 years; P=0.02) compared with those not tested. A total of 4/150 patients (2.6%) received chemotherapy; two received chemotherapy based on RS testing. Based on the current selection criteria for IORT, oncotype testing rarely results in a high‑risk score or utilization of chemotherapy for IORT patients. The present study supports selective use of RS testing in IORT patients and confirms that biologically low‑risk patients are being selected for IORT based on current guidelines.
View Figures
View References

1 

Valente SA, Tendulkar RD, Cherian S, O'Rourke C, Greif JM, Bailey L, Uhl V, Bethke KP, Donnelly ED, Rudolph R, et al: TARGIT-R (Retrospective): North American Experience with Intraoperative Radiation Using Low-Kilovoltage X-Rays for Breast Cancer. Ann Surg Oncol. 23:2809–2815. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Vaidya JS, Joseph DJ, Tobias JS, Bulsara M, Wenz F, Saunders C, Alvarado M, Flyger HL, Massarut S, Eiermann W, et al: Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): An international, prospective, randomised, non-inferiority phase 3 trial. Lancet. 376:91–102. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Correa C, Harris EE, Leonardi MC, Smith BD, Taghian AG, Thompson AM, White J and Harris JR: Accelerated partial breast irradiation: Executive summary for the update of an ASTRO evidence-based consensus statement. Pract Radiat Oncol. 7:73–79. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Roberts MC, Miller DP, Shak S and Petkov VI: Breast cancer-specific survival in patients with lymph node-positive hormone receptor-positive invasive breast cancer and Oncotype DX Recurrence Score results in the SEER database. Breast Cancer Res Treat. 163:303–310. 2017. View Article : Google Scholar : PubMed/NCBI

5 

National Comprehensive Cancer Network Guidelines, B.C. NCCN guidelines version 2.2017 breast cancer. 2.2017 4.18.2017. https://www.nccn.org

6 

Harris LN, Ismaila N, McShane LM, Andre F, Collyar DE, Gonzalez-Angulo AM, Hammond EH, Kuderer NM, Liu MC, Mennel RG, et al: Use of biomarkers to guide decisions on adjuvant systemic therapy for women with early-stage invasive breast cancer: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 34:1134–1150. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Stemmer SM, Klang SH, Ben-Baruch N, Geffen DB, Steiner M, Soussan-Gutman L, Merling S, Svedman C, Rizel S and Lieberman N: The impact of the 21-gene Recurrence Score assay on clinical decision-making in node-positive (up to 3 positive nodes) estrogen receptor-positive breast cancer patients. Breast Cancer Res Treat. 140:83–92. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Dinan MA, Mi X, Reed SD, Hirsch BR, Lyman GH and Curtis LH: Initial trends in the use of the 21-gene recurrence score assay for patients with breast cancer in the Medicare population, 2005–2009. JAMA Oncol. 1:158–166. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Lynch JA, Berse B, Coomer N and Kautter J: 21-gene recurrence score testing among Medicare beneficiaries with breast cancer in 2010–2013. Genet Med. 19:1134–1143. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Carlson JJ and Roth JA: The impact of the Oncotype Dx breast cancer assay in clinical practice: A systematic review and meta-analysis. Breast Cancer Res Treat. 141:13–22. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Orucevic A, Bell JL, McNabb AP and Heidel RE: Oncotype DX breast cancer recurrence score can be predicted with a novel nomogram using clinicopathologic data. Breast Cancer Res Treat. 163:51–61. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Gage MM, Rosman M, Mylander WC, Giblin E, Kim HS, Cope L, Umbricht C, Wolff AC and Tafra L: A validated model for identifying patients unlikely to benefit from the 21-gene recurrence score assay. Clin Breast Cancer. 15:467–472. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Oppong BA, Sen Gupta S, Gary M, Wehner P, Mete M, Zhao D, Seevaratnam S, Rudra S and Willey SC: 21-gene recurrence assay in patients receiving intraoperative radiotherapy: Are ‘favorable’ characteristics a surrogate for low recurrence? Gland Surg. 6:675–681. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Enewold L, Geiger AM, Zujewski J and Harlan LC: Oncotype Dx assay and breast cancer in the United States: Usage and concordance with chemotherapy. Breast Cancer Res Treat. 151:149–156. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Nguyen MT, Stessin A, Nagar H, D'Alfonso TM, Chen Z, Cigler T, Hayes MK and Shin SJ: Impact of oncotype DX recurrence score in the management of breast cancer cases. Clin Breast Cancer. 14:182–190. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Hershman DL, Kushi LH, Shao T, Buono D, Kershenbaum A, Tsai WY, Fehrenbacher L, Gomez SL, Miles S and Neugut AI: Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8,769 early-stage breast cancer patients. J Clin Oncol. 28:4120–4128. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Brier MJ, Chambless DL, Gross R, Chen J and Mao JJ: Perceived barriers to treatment predict adherence to aromatase inhibitors among breast cancer survivors. Cancer. 123:169–176. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Henry NL, Azzouz F, Desta Z, Li L, Nguyen AT, Lemler S, Hayden J, Tarpinian K, Yakim E, Flockhart DA, et al: Predictors of aromatase inhibitor discontinuation as a result of treatment-emergent symptoms in early-stage breast cancer. J Clin Oncol. 30:936–942. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Larson KE, Valente SA, Shah C, Tendulkar RD, Cherian S, Abraham J, Yanda C, Tu C, Echle J, Grobmyer SR, Grobmyer SR, et al: Oncotype testing in patients undergoing intraoperative radiation for breast cancer. Mol Clin Oncol 9: 535-538, 2018.
APA
Larson, K.E., Valente, S.A., Shah, C., Tendulkar, R.D., Cherian, S., Abraham, J. ... Grobmyer, S.R. (2018). Oncotype testing in patients undergoing intraoperative radiation for breast cancer. Molecular and Clinical Oncology, 9, 535-538. https://doi.org/10.3892/mco.2018.1704
MLA
Larson, K. E., Valente, S. A., Shah, C., Tendulkar, R. D., Cherian, S., Abraham, J., Yanda, C., Tu, C., Echle, J., Grobmyer, S. R."Oncotype testing in patients undergoing intraoperative radiation for breast cancer". Molecular and Clinical Oncology 9.5 (2018): 535-538.
Chicago
Larson, K. E., Valente, S. A., Shah, C., Tendulkar, R. D., Cherian, S., Abraham, J., Yanda, C., Tu, C., Echle, J., Grobmyer, S. R."Oncotype testing in patients undergoing intraoperative radiation for breast cancer". Molecular and Clinical Oncology 9, no. 5 (2018): 535-538. https://doi.org/10.3892/mco.2018.1704
Copy and paste a formatted citation
x
Spandidos Publications style
Larson KE, Valente SA, Shah C, Tendulkar RD, Cherian S, Abraham J, Yanda C, Tu C, Echle J, Grobmyer SR, Grobmyer SR, et al: Oncotype testing in patients undergoing intraoperative radiation for breast cancer. Mol Clin Oncol 9: 535-538, 2018.
APA
Larson, K.E., Valente, S.A., Shah, C., Tendulkar, R.D., Cherian, S., Abraham, J. ... Grobmyer, S.R. (2018). Oncotype testing in patients undergoing intraoperative radiation for breast cancer. Molecular and Clinical Oncology, 9, 535-538. https://doi.org/10.3892/mco.2018.1704
MLA
Larson, K. E., Valente, S. A., Shah, C., Tendulkar, R. D., Cherian, S., Abraham, J., Yanda, C., Tu, C., Echle, J., Grobmyer, S. R."Oncotype testing in patients undergoing intraoperative radiation for breast cancer". Molecular and Clinical Oncology 9.5 (2018): 535-538.
Chicago
Larson, K. E., Valente, S. A., Shah, C., Tendulkar, R. D., Cherian, S., Abraham, J., Yanda, C., Tu, C., Echle, J., Grobmyer, S. R."Oncotype testing in patients undergoing intraoperative radiation for breast cancer". Molecular and Clinical Oncology 9, no. 5 (2018): 535-538. https://doi.org/10.3892/mco.2018.1704
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team