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Article

Alternate‑day administration of S‑1 for elderly patients with advanced non‑small‑cell lung carcinoma: A prospective feasibility study

  • Authors:
    • Takeshi Masuda
    • Masako Watanabe
    • Kazunori Fujitaka
    • Kosuke Hamai
    • Nobuhisa Ishikawa
    • Mihoko Doi
    • Soichi Kitaguchi
    • Kakuhiro Yamaguchi
    • Shinjiro Sakamoto
    • Yasushi Horimasu
    • Shintaro Miyamoto
    • Taku Nakashima
    • Tadashi Senoo
    • Hiroshi Iwamoto
    • Hironobu Hamada
    • Noboru Hattori
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Internal Medicine, Hiroshima University Hospital, Hiroshima 734‑8551, Japan, Department of Respiratory Medicine, Hiroshima Prefectural Hospital, Hiroshima 734‑8530, Japan, Department of Clinical Oncology, Hiroshima Prefectural Hospital, Hiroshima 734‑8530, Japan, Department of Medical Oncology, Hiroshima City Asa Citizens' Hospital, Hiroshima 731‑0293, Japan , Department of Clinical Oncology, Hiroshima University Hospital, Hiroshima 734‑8551, Japan
  • Pages: 539-544
    |
    Published online on: August 24, 2018
       https://doi.org/10.3892/mco.2018.1705
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Abstract

S‑1 is an oral fluoropyrimidine agent used for the treatment of non‑small‑cell lung cancer (NSCLC). Although S‑1 monotherapy has been reported to exhibit lesser hematotoxicity compared with other third‑generation chemotherapeutics, digestive toxicity was also frequently observed. Alternate‑day administration of S‑1 has shown a lower rate of severe digestive toxicity than the daily standard administration in patients with NSCLC. However, the safety of alternate‑day S‑1 therapy in elderly patients aged 75 years or older has not been investigated. The present study was a multi‑center and prospective feasibility study aimed to evaluate the safety of alternate‑day S‑1 therapy in elderly patients with NSCLC. The patients received S‑1 orally twice daily for 4 days (Monday, Wednesday, Friday, and Sunday) every week until disease progression or unacceptable toxicity. The primary endpoint was safety, which was evaluated as the number of grade ≥3 adverse events, and the secondary endpoints were progression‑free survival (PFS), 1‑year survival, and disease control rate (DCR). A total of 10 patients were enrolled, but 2 patients failed to initiate the treatment protocol. Finally, 8 patients were treated with the study protocol regimen. No grade 3 or higher adverse events were observed. Four (50%) and 1 (12.5%) patient had grade 2 or lower digestive symptoms such as anorexia, diarrhea, or stomatitis and grade 1 lacrimation, respectively. Moreover, 2 (25%), 1 (12.5%), and 1 (12.5%) patients had grade 2 renal dysfunction, grade 2 ileus, and elevated blood bilirubin, respectively. The median PFS was 1.5 months (95% confidence interval: 0.9‑1.8), and the 1‑year survival rate was 42.9%. The DCR was 12.5%. In conclusion, alternate‑day S‑1 administration can be a safe treatment regimen for elderly patients with NSCLC, but its therapeutic efficacy and safety for elderly patients with NSCLC should be compared against the standard S‑1 administration in a large‑scale study.
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1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Quoix E, Zalcman G, Oster JP, Westeel V, Pichon E, Lavolé A, Dauba J, Debieuvre D, Souquet PJ, Bigay-Game L, et al: Carboplatin and weekly paclitaxel doublet chemotherapy compared with monotherapy in elderly patients with advanced non-small-cell lung cancer: IFCT-0501 randomised, phase 3 trial. Lancet. 378:1079–1088. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Santos FN, de Castria TB, Cruz MR and Riera R: Chemotherapy for advanced non-small cell lung cancer in the elderly population. Cochrane Database Syst Rev: CD010463. 2015. View Article : Google Scholar

4 

National Coprehensive Cancer Network, . Non-small cell lung cancer. NCCN Guidelines for clinical practice in oncology. Version 2. 2018.https://www.nccn.org/professionals/physician_gls/default.aspxMarch 1–2018

5 

Gridelli C, Perrone F, Gallo C, Cigolari S, Rossi A, Piantedosi F, Barbera S, Ferraù F, Piazza E, Rosetti F, et al: Chemotherapy for elderly patients with advanced non-small-cell lung cancer: The multicenter italian lung cancer in the elderly study (MILES) phase III randomized trial. J Natl Cancer Inst. 95:362–372. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. The Elderly Lung Cancer Vinorelbine Italian Study Group. J Natl Cancer Inst. 91:66–72. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Kudoh S, Takeda K, Nakagawa K, Takada M, Katakami N, Matsui K, Shinkai T, Sawa T, Goto I, Semba H, et al: Phase III study of docetaxel compared with vinorelbine in elderly patients with advanced non-small-cell lung cancer: Results of the west Japan thoracic oncology group trial (WJTOG 9904). J Clin Oncol. 24:3657–3663. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Nishio M, Mok TSK, Nakagawa K, et al: EAST-LC: Randomized controlled phase III trial of S-1 versus docetaxel in patients with non-small-cell lung cancer who had received a platinum-based treatment. Ann Oncol. 28:x124–x143. 2017.

9 

Yoshioka H, Okamoto I, Morita S, Ando M, Takeda K, Seto T, Yamamoto N, Saka H, Atagi S, Hirashima T, et al: Efficacy and safety analysis according to histology for S-1 in combination with carboplatin as first-line chemotherapy in patients with advanced non-small-cell lung cancer: Updated results of the west Japan oncology group LETS study. Ann Oncol. 24:1326–1331. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Suzuki A, Maemondo M, Sugawara S, Nakagawa T, Taima K, Inoue A, Matsuno K, Usui K, Yokoi T, Kanbe M, et al: Randomized phase II trial of daily administration versus alternate-day administration of S-1 in patients with advanced non-small cell lung cancer. Cancer Treat Res Commun. 12:56–61. 2017. View Article : Google Scholar

11 

Yamaue H, Shimizu A, Hagiwara Y, Sho M, Yanagimoto H, Nakamori S, Ueno H, Ishii H, Kitano M, Sugimori K, et al: Multicenter, randomized, open-label Phase II study comparing S-1 alternate-day oral therapy with the standard daily regimen as a first-line treatment in patients with unresectable advanced pancreatic cancer. Cancer Chemother Pharmacol. 79:813–823. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Goldstraw P, Crowley J, Chansky K, Giroux DJ, Groome PA, Rami-Porta R, Postmus PE, Rusch V and Sobin L; International Association for the Study of Lung Cancer International Staging Committee; Participating Institutions, : The IASLC lung cancer staging project: Proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol. 2:706–714. 2007. View Article : Google Scholar : PubMed/NCBI

13 

National Cancer institute, . Common terminology criteria for adverse events (CTCAE). https://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htmMarch 1–2018

14 

Lipkin M, Sherlock P and Bell B: CELL proliferation kinetics in the gastrointestinal tract of man. II. Cell renewal in stomach, ileum, colon and rectum. Gastroenterology. 45:721–729. 1963.PubMed/NCBI

15 

Clarkson B, Ota K, Ohkita T and O'Connor A: Kinetics of proliferation of cancer cells in neoplastic effusions in man. Cancer. 18:1189–1213. 1965. View Article : Google Scholar : PubMed/NCBI

16 

Arai W, Hosoya Y, Haruta H, Kurashina K, Saito S, Hirashima Y, Yokoyama T, Zuiki T, Sakuma K, Hyodo M, et al: Comparison of alternate-day versus consecutive-day treatment with S-1: Assessment of tumor growth inhibition and toxicity reduction in gastric cancer cell lines in vitro and in vivo. Int J Clin Oncol. 13:515–520. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Sakuma K, Hosoya Y, Arai W, Haruta H, Ui T, Kurashina K, Saito S, Hirashima Y, Yokoyama T, Zuiki T, et al: Alternate-day treatment with S-1 in patients with gastric cancer: A retrospective study of strategies for reducing toxicity. Int J Clin Oncol. 15:166–171. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Shiroyama T, Kijima T, Komuta K, Yamamoto S, Minami S, Ogata Y, Okafuji K, Imamura F, Hirashima T, Tachibana I, et al: Phase II tailored S-1 regimen study of first-line chemotherapy in elderly patients with advanced and recurrent non-small cell lung cancer. Cancer Chemother Pharmacol. 70:783–789. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Goto H, Okano Y, Machida H, Hatakeyama N, Ogushi F, Haku T, Kanematsu T, Urata T, Kakiuchi S, Hanibuchi M, et al: Phase II study of tailored S-1 monotherapy with a 1-week interval after a 2-week dosing period in elderly patients with advanced non-small cell lung cancer. Respir Investig. 56:80–86. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Masuda T, Watanabe M, Fujitaka K, Hamai K, Ishikawa N, Doi M, Kitaguchi S, Yamaguchi K, Sakamoto S, Horimasu Y, Horimasu Y, et al: Alternate‑day administration of S‑1 for elderly patients with advanced non‑small‑cell lung carcinoma: A prospective feasibility study. Mol Clin Oncol 9: 539-544, 2018.
APA
Masuda, T., Watanabe, M., Fujitaka, K., Hamai, K., Ishikawa, N., Doi, M. ... Hattori, N. (2018). Alternate‑day administration of S‑1 for elderly patients with advanced non‑small‑cell lung carcinoma: A prospective feasibility study. Molecular and Clinical Oncology, 9, 539-544. https://doi.org/10.3892/mco.2018.1705
MLA
Masuda, T., Watanabe, M., Fujitaka, K., Hamai, K., Ishikawa, N., Doi, M., Kitaguchi, S., Yamaguchi, K., Sakamoto, S., Horimasu, Y., Miyamoto, S., Nakashima, T., Senoo, T., Iwamoto, H., Hamada, H., Hattori, N."Alternate‑day administration of S‑1 for elderly patients with advanced non‑small‑cell lung carcinoma: A prospective feasibility study". Molecular and Clinical Oncology 9.5 (2018): 539-544.
Chicago
Masuda, T., Watanabe, M., Fujitaka, K., Hamai, K., Ishikawa, N., Doi, M., Kitaguchi, S., Yamaguchi, K., Sakamoto, S., Horimasu, Y., Miyamoto, S., Nakashima, T., Senoo, T., Iwamoto, H., Hamada, H., Hattori, N."Alternate‑day administration of S‑1 for elderly patients with advanced non‑small‑cell lung carcinoma: A prospective feasibility study". Molecular and Clinical Oncology 9, no. 5 (2018): 539-544. https://doi.org/10.3892/mco.2018.1705
Copy and paste a formatted citation
x
Spandidos Publications style
Masuda T, Watanabe M, Fujitaka K, Hamai K, Ishikawa N, Doi M, Kitaguchi S, Yamaguchi K, Sakamoto S, Horimasu Y, Horimasu Y, et al: Alternate‑day administration of S‑1 for elderly patients with advanced non‑small‑cell lung carcinoma: A prospective feasibility study. Mol Clin Oncol 9: 539-544, 2018.
APA
Masuda, T., Watanabe, M., Fujitaka, K., Hamai, K., Ishikawa, N., Doi, M. ... Hattori, N. (2018). Alternate‑day administration of S‑1 for elderly patients with advanced non‑small‑cell lung carcinoma: A prospective feasibility study. Molecular and Clinical Oncology, 9, 539-544. https://doi.org/10.3892/mco.2018.1705
MLA
Masuda, T., Watanabe, M., Fujitaka, K., Hamai, K., Ishikawa, N., Doi, M., Kitaguchi, S., Yamaguchi, K., Sakamoto, S., Horimasu, Y., Miyamoto, S., Nakashima, T., Senoo, T., Iwamoto, H., Hamada, H., Hattori, N."Alternate‑day administration of S‑1 for elderly patients with advanced non‑small‑cell lung carcinoma: A prospective feasibility study". Molecular and Clinical Oncology 9.5 (2018): 539-544.
Chicago
Masuda, T., Watanabe, M., Fujitaka, K., Hamai, K., Ishikawa, N., Doi, M., Kitaguchi, S., Yamaguchi, K., Sakamoto, S., Horimasu, Y., Miyamoto, S., Nakashima, T., Senoo, T., Iwamoto, H., Hamada, H., Hattori, N."Alternate‑day administration of S‑1 for elderly patients with advanced non‑small‑cell lung carcinoma: A prospective feasibility study". Molecular and Clinical Oncology 9, no. 5 (2018): 539-544. https://doi.org/10.3892/mco.2018.1705
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