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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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December-2018 Volume 9 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Case Report

Miliary lung metastases from non‑small cell lung cancer with Exon 20 insertion: A dismal prognostic entity: A case report

  • Authors:
    • Akimasa Sekine
    • Takuma Katano
    • Tsuneyuki Oda
    • Satoshi Ikeda
    • Tae Iwasawa
    • Hiroaki Satoh
    • Toshiro Kataoka
    • Koji Okudela
    • Takashi Ogura
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Kanagawa 236-0051, Japan, Department of Radiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Kanagawa 236-0051, Japan, Department of Internal Medicine, Mito Medical Center, University of Tsukuba, Tsukuba, Ibaraki 305‑8577, Japan, Department of Pathology, Graduate School of Medicine, Yokohama City University, Yokohama, Kanagawa 236-0027, Japan
  • Pages: 673-676
    |
    Published online on: October 1, 2018
       https://doi.org/10.3892/mco.2018.1730
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Abstract

Miliary lung metastases have been reported to be frequently observed in nοn‑small cell lung cancer (NSCLC) with major EGFR mutations, which consist of exon 19 deletion and exon 21 L858R. However, it remains undetermined whether NSCLC with minor EGFR mutations possesses characteristics similar to those with major EGFR mutations. In the present study, two cases of miliary lung metastases from NSCLC with exon 20 insertion were reported. Both the patients visited our hospital because of cough and/or dyspnea and were treated with chemotherapeutic agents, including platinum‑doublet regimen. In addition, 1 patient received afatinib during the clinical course. However, all therapeutic regimens did not result in the desired outcome, and the respiratory condition rapidly deteriorated. Both the patients succumbed to disease within 3 months from the beginning of the 1st‑line treatment due to disease progression. To conclude, chest physicians should be aware that miliary lung metastases could develop in NSCLC patients with exon 20 insertion and present a dismal prognosis.
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1 

Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, et al: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 350:2129–2139. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, et al: EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science. 304:1497–1500. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Togashi Y, Masago K, Kubo T, Sakamori Y, Kim YH, Hatachi Y, Fukuhara A, Mio T, Togashi K and Mishima M: Association of diffuse, random pulmonary metastases, including miliary metastases, with epidermal growth factor receptor mutations in lung adenocarcinoma. Cancer. 117:819–825. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Wu SG, Hu FC, Chang YL, Lee YC, Yu CJ, Chang YC, Wu JY, Shih JY and Yang PC: Frequent EGFR mutations in NSCLC presenting with miliary intrapulmonary carcinomatosis. Eur Respir J. 41:417–424. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Sekine A, Kato T, Hagiwara E, Shinohara T, Komagata T, Iwasawa T, Satoh H, Tamura K, Kasamatsu T, Hayashihara K, et al: Metastatic brain tumors from non-small cell lung cancer with EGFR mutations: Distinguishing influence of exon 19 deletion on radiographic features. Lung Cancer. 77:64–69. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Mochizuki S, Nishimura N, Inoue A, Murakami K, Nukiwa T and Chohnabayashi N: Miliary brain metastases in 2 cases with advanced non-small cell lung cancer harboring EGFR mutation during gefitinib treatment. Respir Investig. 50:117–121. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Naidoo J, Sima CS, Rodriguez K, Busby N, Nafa K, Ladanyi M, Riely GJ, Kris MG, Arcila ME and Yu HA: Epidermal growth factor receptor exon 20 insertions in advanced lung adenocarcinomas: Clinical outcomes and response to erlotinib. Cancer. 121:3212–3220. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Noronha V, Choughule A, Patil VM, Joshi A, Kumar R, Susan Joy, Philip D, Banavali S, Dutt A and Prabhash K: Epidermal growth factor receptor exon 20 mutation in lung cancer: Types, incidence, clinical features and impact on treatment. Onco Targets Ther. 10:2903–2908. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Yasuda H, Kobayashi S and Costa DB: EGFR exon 20 insertion mutations in non-small-cell lung cancer: Preclinical data and clinical implications. Lancet Oncol. 13:e23–e31. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Laack E, Simon R, Regier M, Andritzky B, Tennstedt P, Habermann C, Verth CZ, Thöm I, Grob T, Sauter G and Bokemeyer C: Miliary never-smoking adenocarcinoma of the lung: Strong association with epidermal growth factor receptor exon 19 deletion. J Thorac Oncol. 6:199–202. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Falk AT, Poudenx M, Otto J, Ghalloussi H and Barrière J: Adenocarcinoma of the lung with miliary brain and pulmonary metastases with echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase translocation treated with crizotinib: A case report. Lung Cancer. 78:282–284. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Dziadziuszko K, Szurowska E, Pienkowska J, Jassem J and Dziadziuszko R: Miliary brain metastases in a patient with ROS1-rearranged lung adenocarcin-oma: A case report. J Thorac Oncol. 9:e34–e36. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Oxnard GR, Lo PC, Nishino M, Dahlberg SE, Lindeman NI, Butaney M, Jackman DM, Johnson BE and Jänne PA: Natural history and molecular characteristics of lung cancers harboring EGFR exon 20 insertions. J Thorac Oncol. 8:179–184. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Lund-Iversen M, Kleinberg L, Fjellbirkeland L, Helland Å and Brustugun OT: Clinicopathological characteristics of 11 NSCLC patients with EGFR-exon 20 mutations. J Thorac Oncol. 7:1471–1473. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Beau-Faller M, Prim N, Ruppert AM, Nanni-Metéllus I, Lacave R, Lacroix L, Escande F, Lizard S, Pretet JL, Rouquette I, et al: Rare EGFR exon 18 and exon 20 mutations in non-small-cell lung cancer on 10 117 patients: A multicentre observational study by the French ERMETIC-IFCT network. Ann Oncol. 25:126–131. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Yang JC, Sequist LV, Geater SL, Tsai CM, Mok TS, Schuler M, Yamamoto N, Yu CJ, Ou SH, Zhou C, et al: Clinical activity of afatinib in patients with advanced non-small-cell lung cancer harbouring uncommon EGFR mutations: A combined post-hoc analysis of LUX-Lung 2, LUX-Lung 3 and LUX-Lung 6. Lancet Oncol. 16:830–838. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sekine A, Katano T, Oda T, Ikeda S, Iwasawa T, Satoh H, Kataoka T, Okudela K and Ogura T: Miliary lung metastases from non‑small cell lung cancer with Exon 20 insertion: A dismal prognostic entity: A case report. Mol Clin Oncol 9: 673-676, 2018.
APA
Sekine, A., Katano, T., Oda, T., Ikeda, S., Iwasawa, T., Satoh, H. ... Ogura, T. (2018). Miliary lung metastases from non‑small cell lung cancer with Exon 20 insertion: A dismal prognostic entity: A case report. Molecular and Clinical Oncology, 9, 673-676. https://doi.org/10.3892/mco.2018.1730
MLA
Sekine, A., Katano, T., Oda, T., Ikeda, S., Iwasawa, T., Satoh, H., Kataoka, T., Okudela, K., Ogura, T."Miliary lung metastases from non‑small cell lung cancer with Exon 20 insertion: A dismal prognostic entity: A case report". Molecular and Clinical Oncology 9.6 (2018): 673-676.
Chicago
Sekine, A., Katano, T., Oda, T., Ikeda, S., Iwasawa, T., Satoh, H., Kataoka, T., Okudela, K., Ogura, T."Miliary lung metastases from non‑small cell lung cancer with Exon 20 insertion: A dismal prognostic entity: A case report". Molecular and Clinical Oncology 9, no. 6 (2018): 673-676. https://doi.org/10.3892/mco.2018.1730
Copy and paste a formatted citation
x
Spandidos Publications style
Sekine A, Katano T, Oda T, Ikeda S, Iwasawa T, Satoh H, Kataoka T, Okudela K and Ogura T: Miliary lung metastases from non‑small cell lung cancer with Exon 20 insertion: A dismal prognostic entity: A case report. Mol Clin Oncol 9: 673-676, 2018.
APA
Sekine, A., Katano, T., Oda, T., Ikeda, S., Iwasawa, T., Satoh, H. ... Ogura, T. (2018). Miliary lung metastases from non‑small cell lung cancer with Exon 20 insertion: A dismal prognostic entity: A case report. Molecular and Clinical Oncology, 9, 673-676. https://doi.org/10.3892/mco.2018.1730
MLA
Sekine, A., Katano, T., Oda, T., Ikeda, S., Iwasawa, T., Satoh, H., Kataoka, T., Okudela, K., Ogura, T."Miliary lung metastases from non‑small cell lung cancer with Exon 20 insertion: A dismal prognostic entity: A case report". Molecular and Clinical Oncology 9.6 (2018): 673-676.
Chicago
Sekine, A., Katano, T., Oda, T., Ikeda, S., Iwasawa, T., Satoh, H., Kataoka, T., Okudela, K., Ogura, T."Miliary lung metastases from non‑small cell lung cancer with Exon 20 insertion: A dismal prognostic entity: A case report". Molecular and Clinical Oncology 9, no. 6 (2018): 673-676. https://doi.org/10.3892/mco.2018.1730
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