Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
December-2018 Volume 9 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2018 Volume 9 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Radiotherapy‑associated intra‑abdominal angiosarcoma after prostatic adenocarcinoma: Case reports

  • Authors:
    • David Parada Domínguez
    • Karla B. Peña Gonzalez
  • View Affiliations / Copyright

    Affiliations: Pathology Service, University Hospital of Saint Joan, Faculty of Medicine, IISPV, ‘Rovira i Virgili’ University, Reus, 43204 Tarragona, Spain
    Copyright: © Parada Domínguez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 592-596
    |
    Published online on: October 5, 2018
       https://doi.org/10.3892/mco.2018.1738
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Angiosarcoma is a rare soft tissue neoplasm, which accounts for <1% of all soft tissue tumours. It has been previously reported that the incidence rate of angiosarcomas increases following radiotherapy. The present study reports two cases of intra‑abdominal angiosarcoma associated with previous radiotherapy treatment. To the best of our knowledge, these associations have not been previously described in English literature. The patients aged 71 and 83 years were admitted to the center for abdominal pain and diarrhea. Each patient had previously had treatment with radiotherapy for prostate adenocarcinoma. During their hospitalization, biopsies were obtained and the diagnosis of angiosarcoma was reached. In each patient the tumors had irregular proliferating vascular channels, lined by atypical endothelial cells, which varied from elongated and spindle‑shaped to large and plump. Immunocytochemistry revealed that the tumor cells were positive for the cytoplasmic endothelial markers cluster of differentiation (CD)31 and CD34. The recognition of these associations is important and their occurrence in this rare type of neoplasm should not mislead the pathologist and cause a misdiagnosis of the sarcoma.
View Figures

Figure 1

Figure 2

View References

1 

Doyle LA: Sarcoma classification: An update based on the 2013 World Health Organization classification of tumors of soft tissue and bone. Cancer. 120:1763–1774. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Mastrangelo G, Coindre JM, Ducimetière F, Dei Tos AP, Fadda E, Blay JY, Buja A, Fedeli U, Cegolon L, Frasson A, et al: Incidence of soft tissue sarcoma and beyond: A population-based prospective study in 3 European regions. Cancer. 118:5339–5348. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Antonescu C: Malignant vascular tumors-an update. Mod Pathol. 27 (Suppl 1):S30–S38. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Wolov RB, Sato N, Azumi N and Lack EE: Intra-abdominal ‘angiosarcomatosis’ report of two cases after pelvic irradiation. Cancer. 67:2275–2279. 1991. View Article : Google Scholar : PubMed/NCBI

5 

Kumar S: Second malignant neoplasms following radiotherapy. Int J Environ Res Public Health. 9:4744–4759. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Sholl LM, Barletta JA and Hornick JL: Radiation-associated neoplasia: Clinical, pathological and genomic correlates. Histopathology. 70:70–80. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Anzalone CL, Cohen PR, Diwan AH and Prieto VG: Radiation-induced angiosarcoma. Dermatol Online J. 19:22013.PubMed/NCBI

8 

Virtanen A, Pukkala E and Auvinen A: Incidence of bone and soft tissue sarcoma after radiotherapy: A cohort study of 295,712 Finnish cancer patients. Int J Cancer. 118:1017–1021. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Virtanen A, Pukkala E and Auvinen A: Angiosarcoma after radiotherapy: A cohort study of 332,163 Finnish cancer patients. Br J Cancer. 97:115–117. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Bhojani N, Capitanio U, Suardi N, Jeldres C, Isbarn H, Shariat SF, Graefen M, Arjane P, Duclos A, Lattouf JB, et al: The rate of secondary malignancies after radical prostatectomy versus external beam radiation therapy for localized prostate cancer: A population-based study on 17,845 patients. Int J Radiat Oncol Biol Phys. 76:342–348. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Wallis CJ, Mahar AL, Choo R, Herschorn S, Kodama RT, Shah PS, Danjoux C, Narod SA and Nam RK: Second malignancies after radiotherapy for prostate cancer: Systematic review and meta-analysis. BMJ. 352:i8512016. View Article : Google Scholar : PubMed/NCBI

12 

Wang G, Black PC, Skinnider BF, Hayes MM and Jones EC: Post-radiation epithelioid angiosarcoma of the urinary bladder and prostate. Can Urol Assoc J. 10:E197–E200. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Gupta A, Patnaik MM and Naina HV: Angiosarcoma of the prostate gland following brachytherapy for prostatic adenocarcinoma. Curr Urol. 8:109–112. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Ojerholm E, Stripp D, Mamtani R, Van Arsdalen K and Tripp P: Angiosarcoma of the bladder following prostate radiotherapy. Am J Med. 128:e11–e12. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Chandan VS and Wolsh L: Postirradiation angiosarcoma of the prostate. Arch Pathol Lab Med. 127:876–878. 2003.PubMed/NCBI

16 

Sakemi M, Sakemi R, Harada M, So S, Uchiyama D, Morimitsu Y, Kakiuchi S, Ishihara Y, Kubo Y, Matsugaki S, et al: A case of postirradiation angiosarcoma of the greater omentum with hemorrhage. Clin J Gastroenterol. 4:302–306. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Cahan WG, Woodard HQ, et al: Sarcoma arising in irradiated bone; report of 11 cases. Cancer. 1:3–29. 1948. View Article : Google Scholar : PubMed/NCBI

18 

Wade MA, May FE, Onel K and Allan JM: Does radiation-induced c-MYC amplification initiate breast oncogenesis? Mol Cell Oncol. 3:e10109502015. View Article : Google Scholar : PubMed/NCBI

19 

Wade MA, Sunter NJ, Fordham SE, Long A, Masic D, Russell LJ, Harrison CJ, Rand V, Elstob C, Bown N, et al: c-MYC is a radiosensitive locus in human breast cells. Oncogene. 34:4985–4994. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Styring E, Seinen J, Dominguez-Valentin M, Domanski HA, Jönsson M, von Steyern FV, Hoekstra HJ, Suurmeijer AJ and Nilbert M: Key roles for MYC KIT and RET signaling in secondary angiosarcomas. Br J Cancer. 111:407–412. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Manner J, Radlwimmer B, Hohenberger P, Mössinger K, Küffer S, Sauer C, Belharazem D, Zettl A, Coindre JM, Hallermann C, et al: MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema. Am J Pathol. 176:34–39. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Fraga-Guedes C, André S, Mastropasqua MG, Botteri E, Toesca A, Rocha RM, Peradze N, Rotmensz N, Viale G, Veronesi P and Gobbi H: Angiosarcoma and atypical vascular lesions of the breast: Diagnostic and prognostic role of MYC gene amplification and protein expression. Breast Cancer Res Treat. 151:131–140. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Fernandez AP, Sun Y, Tubbs RR, Goldblum JR and Billings SD: FISH for MYC amplification and anti-MYC immunohistochemistry: Useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferations. J Cutan Pathol. 39:234–242. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Laé M, Lebel A, Hamel-Viard F, Asselain B, Trassard M, Sastre X and Kirova YM: Can c-myc amplification reliably discriminate postradiation from primary angiosarcoma of the breast? Cancer Radiother. 19:168–174. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Mentzel T, Schildhaus HU, Palmedo G, Büttner R and Kutzner H: Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis of 66 cases. Mod Pathol. 25:75–85. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Mark RJ, Poen J, Tran LM, Fu YS, Selch MT and Parker RG: Postirradiation sarcomas. A single-institution study and review of the literature. Cancer. 73:2653–2662. 1994.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Parada Domínguez D and Peña Gonzalez KB: Radiotherapy‑associated intra‑abdominal angiosarcoma after prostatic adenocarcinoma: Case reports. Mol Clin Oncol 9: 592-596, 2018.
APA
Parada Domínguez, D. ., & Peña Gonzalez, K.B. (2018). Radiotherapy‑associated intra‑abdominal angiosarcoma after prostatic adenocarcinoma: Case reports. Molecular and Clinical Oncology, 9, 592-596. https://doi.org/10.3892/mco.2018.1738
MLA
Parada Domínguez, D. ., Peña Gonzalez, K. B."Radiotherapy‑associated intra‑abdominal angiosarcoma after prostatic adenocarcinoma: Case reports". Molecular and Clinical Oncology 9.6 (2018): 592-596.
Chicago
Parada Domínguez, D. ., Peña Gonzalez, K. B."Radiotherapy‑associated intra‑abdominal angiosarcoma after prostatic adenocarcinoma: Case reports". Molecular and Clinical Oncology 9, no. 6 (2018): 592-596. https://doi.org/10.3892/mco.2018.1738
Copy and paste a formatted citation
x
Spandidos Publications style
Parada Domínguez D and Peña Gonzalez KB: Radiotherapy‑associated intra‑abdominal angiosarcoma after prostatic adenocarcinoma: Case reports. Mol Clin Oncol 9: 592-596, 2018.
APA
Parada Domínguez, D. ., & Peña Gonzalez, K.B. (2018). Radiotherapy‑associated intra‑abdominal angiosarcoma after prostatic adenocarcinoma: Case reports. Molecular and Clinical Oncology, 9, 592-596. https://doi.org/10.3892/mco.2018.1738
MLA
Parada Domínguez, D. ., Peña Gonzalez, K. B."Radiotherapy‑associated intra‑abdominal angiosarcoma after prostatic adenocarcinoma: Case reports". Molecular and Clinical Oncology 9.6 (2018): 592-596.
Chicago
Parada Domínguez, D. ., Peña Gonzalez, K. B."Radiotherapy‑associated intra‑abdominal angiosarcoma after prostatic adenocarcinoma: Case reports". Molecular and Clinical Oncology 9, no. 6 (2018): 592-596. https://doi.org/10.3892/mco.2018.1738
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team