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Pathological complete response to mFOLFOX6 plus cetuximab therapy for unresectable colon cancer with multiple paraaortic lymph node metastases

  • Authors:
    • Tomonari Suetsugu
    • Nobuhisa Matsuhashi
    • Takao Takahashi
    • Toshiyuki Tanahashi
    • Satoshi  Matsui
    • Hisashi Imai
    • Yoshihiro Tanaka
    • Kazuya Yamaguchi
    • Kazuhiro Yoshida
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Gifu University School of Medicine, Gifu, Gifu 501-1194, Japan
    Copyright: © Suetsugu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 587-591
    |
    Published online on: October 5, 2018
       https://doi.org/10.3892/mco.2018.1742
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Abstract

Pathological complete response is achievable with mFOLFOX6 plus cetuximab therapy for unresectable colorectal cancer with multiple paraaortic lymph node metastases (mCRC) despite right-sided colonic origin. A 62-year-old woman with synchronous paraaortic lymph node metastases of transverse colon cancer was treated with mFOLFOX6 plus cetuximab as first-line therapy. The tumor size was markedly decreased following 6 courses of chemotherapy, and all lymph node metastases had disappeared. The patient then underwent conventional right hemicolectomy with D3 lymph node dissection plus sampling excision of the paraaortic lymph nodes. The pathological diagnosis was a complete response. The patient is currently alive 5 years after surgery with no signs of recurrence. The present study reported the apparent effectiveness of conversion therapy (surgery) with combination treatment with mFOLFOX6 plus cetuximab and radical surgery. We hypothesized that patients with different types of mCRC of right-sided colon origin may be effectively treated with anti‑EGFR monoclonal antibodies.
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Copy and paste a formatted citation
Spandidos Publications style
Suetsugu T, Matsuhashi N, Takahashi T, Tanahashi T, Matsui S, Imai H, Tanaka Y, Yamaguchi K and Yoshida K: Pathological complete response to mFOLFOX6 plus cetuximab therapy for unresectable colon cancer with multiple paraaortic lymph node metastases. Mol Clin Oncol 9: 587-591, 2018.
APA
Suetsugu, T., Matsuhashi, N., Takahashi, T., Tanahashi, T., Matsui, S., Imai, H. ... Yoshida, K. (2018). Pathological complete response to mFOLFOX6 plus cetuximab therapy for unresectable colon cancer with multiple paraaortic lymph node metastases. Molecular and Clinical Oncology, 9, 587-591. https://doi.org/10.3892/mco.2018.1742
MLA
Suetsugu, T., Matsuhashi, N., Takahashi, T., Tanahashi, T., Matsui, S., Imai, H., Tanaka, Y., Yamaguchi, K., Yoshida, K."Pathological complete response to mFOLFOX6 plus cetuximab therapy for unresectable colon cancer with multiple paraaortic lymph node metastases". Molecular and Clinical Oncology 9.6 (2018): 587-591.
Chicago
Suetsugu, T., Matsuhashi, N., Takahashi, T., Tanahashi, T., Matsui, S., Imai, H., Tanaka, Y., Yamaguchi, K., Yoshida, K."Pathological complete response to mFOLFOX6 plus cetuximab therapy for unresectable colon cancer with multiple paraaortic lymph node metastases". Molecular and Clinical Oncology 9, no. 6 (2018): 587-591. https://doi.org/10.3892/mco.2018.1742
Copy and paste a formatted citation
x
Spandidos Publications style
Suetsugu T, Matsuhashi N, Takahashi T, Tanahashi T, Matsui S, Imai H, Tanaka Y, Yamaguchi K and Yoshida K: Pathological complete response to mFOLFOX6 plus cetuximab therapy for unresectable colon cancer with multiple paraaortic lymph node metastases. Mol Clin Oncol 9: 587-591, 2018.
APA
Suetsugu, T., Matsuhashi, N., Takahashi, T., Tanahashi, T., Matsui, S., Imai, H. ... Yoshida, K. (2018). Pathological complete response to mFOLFOX6 plus cetuximab therapy for unresectable colon cancer with multiple paraaortic lymph node metastases. Molecular and Clinical Oncology, 9, 587-591. https://doi.org/10.3892/mco.2018.1742
MLA
Suetsugu, T., Matsuhashi, N., Takahashi, T., Tanahashi, T., Matsui, S., Imai, H., Tanaka, Y., Yamaguchi, K., Yoshida, K."Pathological complete response to mFOLFOX6 plus cetuximab therapy for unresectable colon cancer with multiple paraaortic lymph node metastases". Molecular and Clinical Oncology 9.6 (2018): 587-591.
Chicago
Suetsugu, T., Matsuhashi, N., Takahashi, T., Tanahashi, T., Matsui, S., Imai, H., Tanaka, Y., Yamaguchi, K., Yoshida, K."Pathological complete response to mFOLFOX6 plus cetuximab therapy for unresectable colon cancer with multiple paraaortic lymph node metastases". Molecular and Clinical Oncology 9, no. 6 (2018): 587-591. https://doi.org/10.3892/mco.2018.1742
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