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Secondary osteosarcoma in patients previously treated for childhood cancer: Three case reports

  • Authors:
    • Akiyoshi Shimatani
    • Masanari Aono
    • Manabu Hoshi
    • Naoto Oebisu
    • Tadashi Iwai
    • Naoki Takada
    • Junichi Hara
    • Chika Nitani
    • Hiroaki Nakamura
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka 545‑8585, Japan, Department of Orthopedic Surgery, Osaka City General Hospital, Osaka 534‑0021, Japan, Department of Pediatric Hematology and Oncology, Osaka City General Hospital, Osaka, Osaka 534‑0021, Japan
  • Pages: 153-158
    |
    Published online on: October 26, 2018
       https://doi.org/10.3892/mco.2018.1752
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Abstract

The prognosis of childhood cancers has improved markedly, and the proportion of long‑term survivors has increased in recent years. However, with the increase in the number of long‑term survivors, the development of latent treatment‑related adverse effects, such as secondary malignancies, has generated new problems. Secondary cancer is defined as a histologically distinct malignancy that develops at least 2 months after the completion of treatment for primary cancer. Genetic factors and acquired conditions associated with treatment modalities are possible causes of secondary malignancy development. Genetic factors include the presence of Li‑Fraumeni syndrome (LFS) and retinoblastoma. In terms of acquired factors, radiation and chemotherapy have been reported to be the most strongly associated with secondary malignancy development. The use of alkylating agents and topoisomerase II inhibitors for the treatment of childhood cancer increases the subsequent risk of secondary tumors. We herein investigated three cases of secondary osteosarcoma several years after treatment for primary cancer. In the three patients, the familial history did not appear to fit the clinical diagnostic criteria of LFS or retinoblastoma. The patients had not received previous radiation therapy to the anatomical site of the secondary cancer. However, high dosages of alkylating agents and topoisomerase II inhibitors had been administered for the treatment of primary cancer. The exact link between chemotherapy and secondary cancer remains elusive, but the possibility of an association should be considered. Following the development of multidisciplinary therapies, long‑term follow‑up and monitoring of latent adverse effects may be necessary for childhood cancer survivors.
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Copy and paste a formatted citation
Spandidos Publications style
Shimatani A, Aono M, Hoshi M, Oebisu N, Iwai T, Takada N, Hara J, Nitani C and Nakamura H: Secondary osteosarcoma in patients previously treated for childhood cancer: Three case reports. Mol Clin Oncol 10: 153-158, 2019.
APA
Shimatani, A., Aono, M., Hoshi, M., Oebisu, N., Iwai, T., Takada, N. ... Nakamura, H. (2019). Secondary osteosarcoma in patients previously treated for childhood cancer: Three case reports. Molecular and Clinical Oncology, 10, 153-158. https://doi.org/10.3892/mco.2018.1752
MLA
Shimatani, A., Aono, M., Hoshi, M., Oebisu, N., Iwai, T., Takada, N., Hara, J., Nitani, C., Nakamura, H."Secondary osteosarcoma in patients previously treated for childhood cancer: Three case reports". Molecular and Clinical Oncology 10.1 (2019): 153-158.
Chicago
Shimatani, A., Aono, M., Hoshi, M., Oebisu, N., Iwai, T., Takada, N., Hara, J., Nitani, C., Nakamura, H."Secondary osteosarcoma in patients previously treated for childhood cancer: Three case reports". Molecular and Clinical Oncology 10, no. 1 (2019): 153-158. https://doi.org/10.3892/mco.2018.1752
Copy and paste a formatted citation
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Spandidos Publications style
Shimatani A, Aono M, Hoshi M, Oebisu N, Iwai T, Takada N, Hara J, Nitani C and Nakamura H: Secondary osteosarcoma in patients previously treated for childhood cancer: Three case reports. Mol Clin Oncol 10: 153-158, 2019.
APA
Shimatani, A., Aono, M., Hoshi, M., Oebisu, N., Iwai, T., Takada, N. ... Nakamura, H. (2019). Secondary osteosarcoma in patients previously treated for childhood cancer: Three case reports. Molecular and Clinical Oncology, 10, 153-158. https://doi.org/10.3892/mco.2018.1752
MLA
Shimatani, A., Aono, M., Hoshi, M., Oebisu, N., Iwai, T., Takada, N., Hara, J., Nitani, C., Nakamura, H."Secondary osteosarcoma in patients previously treated for childhood cancer: Three case reports". Molecular and Clinical Oncology 10.1 (2019): 153-158.
Chicago
Shimatani, A., Aono, M., Hoshi, M., Oebisu, N., Iwai, T., Takada, N., Hara, J., Nitani, C., Nakamura, H."Secondary osteosarcoma in patients previously treated for childhood cancer: Three case reports". Molecular and Clinical Oncology 10, no. 1 (2019): 153-158. https://doi.org/10.3892/mco.2018.1752
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