Metastatic squamous cell carcinoma to the pancreas: Report of an extremely rare case

Machairas,Nikolaos; Paspala,Anna; Schizas,Dimitrios; Ntomi,Vasileia; Moris,Dimitrios; Tsilimigras,Diamantis  I.; Misiakos,Evangelos  P.; Machairas,Anastasios

doi:10.3892/mco.2018.1756

January-2019 Volume 10 Issue 1

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January-2019 Volume 10 Issue 1

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Article

Metastatic squamous cell carcinoma to the pancreas: Report of an extremely rare case

Authors:
- Nikolaos Machairas
- Anna Paspala
- Dimitrios Schizas
- Vasileia Ntomi
- Dimitrios Moris
- Diamantis I. Tsilimigras
- Evangelos P. Misiakos
- Anastasios Machairas
View Affiliations / Copyright

Affiliations: Third Department of Surgery, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece, Department of Surgery, Duke University Medical Center, Duke University, Durham, NC 27708, USA
Pages: 144-146
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Published online on: November 1, 2018

https://doi.org/10.3892/mco.2018.1756
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Abstract

Secondary pancreatic lesions are very uncommon. Resection of these metastatic lesions with a curative intent has been reported in selected patients; however, the survival benefit from these procedures has yet to be clearly determined. A 78‑year‑old male patient presented to our department with obstructive jaundice. Three years prior to presentation the patient had undergone right pneumonectomy, due to stage IIA, low‑grade squamous cell lung carcinoma. After resection, the patient received adjuvant chemotherapy, with no evidence of local or systemic recurrence over the following 3 years. Abdominal computer tomography on admission revealed a 3‑cm lesion located at the head of the pancreas, causing biliary obstruction. Endoscopic ultrasound biopsy revealed malignant cells, suspicious for squamous cell carcinoma. Due to the limited extent of the metastatic disease and in view of the patient's good condition, surgical resection was proposed and the patient successfully underwent pancreaticoduodenectomy. Histological examination of the resected specimen confirmed a squamous cell carcinoma, with an immunochemical profile similar to that of the primary lung tumor. Therefore, pancreatic resection with curative intent may be feasible in selected patients with secondary metastatic tumors. However, further studies are required in order to determine the benefit of these major procedures in terms of survival outcomes.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Metastatic squamous cell carcinoma to the pancreas: Report of an extremely rare case

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Abstract

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