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Article

Core needle biopsy promotes lung metastasis of breast cancer: An experimental study

  • Authors:
    • Yongqiang Fu
    • Fangming Guo
    • Haohao Chen
    • Yiping Lin
    • Xiaoyan Fu
    • Hui Zhang
    • Mingxing Ding
  • View Affiliations / Copyright

    Affiliations: Department of Medical Sciences, Jinhua Polytechnic, Jinhua, Zhejiang 321007, P.R. China, Department of Laboratory Animals Center, Jinhua Institute for Food and Drug Control, Jinhua, Zhejiang 321000, P.R. China
  • Pages: 253-260
    |
    Published online on: December 5, 2018
       https://doi.org/10.3892/mco.2018.1784
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Abstract

Core needle biopsy (CNB) may be used to diagnose early‑stage breast cancer, but it may increase the risk of distant metastasis of tumor cells. The aim of the present study was to explore the effect of CNB on the distant metastasis of breast cancer. A total of 30 BALB/c mice were divided into two groups, namely biopsy and non‑biopsy groups. The biopsy‑related lung metastasis model (biopsy group) was established by the inoculation in the mammary fat pad of the mouse breast cancer cell line 4T1 combined with CNB. Flow cytometry, quantitative polymerase chain reaction analysis, morphological analysis, as well as other techniques, were used to evaluate the biological behavior of the tumors in the mouse model. A stable and reliable lung metastasis model of breast cancer was successfully established. The number of metastatic lung nodules in the biopsy group was significantly higher compared with that in the non‑biopsy group (P<0.05). Compared with the non‑biopsy group, the mRNA expression of transforming growth factor (TGF)‑β1, SOX4 and Ezh2 in the biopsy group was significantly upregulated (P<0.05) and the number of natural killer (NK) cells detected by flow cytometry was increased, but the difference was not statistically significant (P>0.05). Therefore, CNB was found to promote the lung metastasis of breast cancer, and the underlying mechanism may be associated with epithelial‑to‑mesenchymal transition (EMT) mediated by the TGF‑β1 signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Fu Y, Guo F, Chen H, Lin Y, Fu X, Zhang H and Ding M: Core needle biopsy promotes lung metastasis of breast cancer: An experimental study. Mol Clin Oncol 10: 253-260, 2019.
APA
Fu, Y., Guo, F., Chen, H., Lin, Y., Fu, X., Zhang, H., & Ding, M. (2019). Core needle biopsy promotes lung metastasis of breast cancer: An experimental study. Molecular and Clinical Oncology, 10, 253-260. https://doi.org/10.3892/mco.2018.1784
MLA
Fu, Y., Guo, F., Chen, H., Lin, Y., Fu, X., Zhang, H., Ding, M."Core needle biopsy promotes lung metastasis of breast cancer: An experimental study". Molecular and Clinical Oncology 10.2 (2019): 253-260.
Chicago
Fu, Y., Guo, F., Chen, H., Lin, Y., Fu, X., Zhang, H., Ding, M."Core needle biopsy promotes lung metastasis of breast cancer: An experimental study". Molecular and Clinical Oncology 10, no. 2 (2019): 253-260. https://doi.org/10.3892/mco.2018.1784
Copy and paste a formatted citation
x
Spandidos Publications style
Fu Y, Guo F, Chen H, Lin Y, Fu X, Zhang H and Ding M: Core needle biopsy promotes lung metastasis of breast cancer: An experimental study. Mol Clin Oncol 10: 253-260, 2019.
APA
Fu, Y., Guo, F., Chen, H., Lin, Y., Fu, X., Zhang, H., & Ding, M. (2019). Core needle biopsy promotes lung metastasis of breast cancer: An experimental study. Molecular and Clinical Oncology, 10, 253-260. https://doi.org/10.3892/mco.2018.1784
MLA
Fu, Y., Guo, F., Chen, H., Lin, Y., Fu, X., Zhang, H., Ding, M."Core needle biopsy promotes lung metastasis of breast cancer: An experimental study". Molecular and Clinical Oncology 10.2 (2019): 253-260.
Chicago
Fu, Y., Guo, F., Chen, H., Lin, Y., Fu, X., Zhang, H., Ding, M."Core needle biopsy promotes lung metastasis of breast cancer: An experimental study". Molecular and Clinical Oncology 10, no. 2 (2019): 253-260. https://doi.org/10.3892/mco.2018.1784
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