Open Access

Prognostic and therapeutic role of HER2 expression in micropapillary carcinoma of the bladder (Review)

  • Authors:
    • Francesca Sanguedolce
    • Davide Russo
    • Vito Mancini
    • Oscar Selvaggio
    • Beppe Calo
    • Giuseppe Carrieri
    • Luigi Cormio
  • View Affiliations

  • Published online on: December 7, 2018     https://doi.org/10.3892/mco.2018.1786
  • Pages: 205-213
  • Copyright: © Sanguedolce et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Micropapillary carcinoma of the bladder (MPBC) is a variant type of infiltrating urothelial carcinoma, which portends a poor biological behavior in terms of disease stage at first diagnosis and clinical outcome; its peculiar morphology raises issues concerning the ability of tumor detection by imaging techniques and proper biopsy procedure, and the appropriate treatment for non‑muscle infiltrating and muscle‑infiltrating MPBC remains a matter of debate. On the basis of its established prognostic and therapeutic role in breast and gastro‑esophageal cancer in the first instance, the human epidermal growth factor receptor‑2 (HER2) has been investigated in selected case series of MPBC over the last 10 years. The aim of the present review was to summarize the existing evidence on HER2 status in MPBC, and to discuss its present and future utility in risk assessment and treatment choice of this uncommon, yet aggressive, disease.
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February-2019
Volume 10 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Sanguedolce F, Russo D, Mancini V, Selvaggio O, Calo B, Carrieri G and Cormio L: Prognostic and therapeutic role of HER2 expression in micropapillary carcinoma of the bladder (Review). Mol Clin Oncol 10: 205-213, 2019
APA
Sanguedolce, F., Russo, D., Mancini, V., Selvaggio, O., Calo, B., Carrieri, G., & Cormio, L. (2019). Prognostic and therapeutic role of HER2 expression in micropapillary carcinoma of the bladder (Review). Molecular and Clinical Oncology, 10, 205-213. https://doi.org/10.3892/mco.2018.1786
MLA
Sanguedolce, F., Russo, D., Mancini, V., Selvaggio, O., Calo, B., Carrieri, G., Cormio, L."Prognostic and therapeutic role of HER2 expression in micropapillary carcinoma of the bladder (Review)". Molecular and Clinical Oncology 10.2 (2019): 205-213.
Chicago
Sanguedolce, F., Russo, D., Mancini, V., Selvaggio, O., Calo, B., Carrieri, G., Cormio, L."Prognostic and therapeutic role of HER2 expression in micropapillary carcinoma of the bladder (Review)". Molecular and Clinical Oncology 10, no. 2 (2019): 205-213. https://doi.org/10.3892/mco.2018.1786