Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
February-2019 Volume 10 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2019 Volume 10 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Complete remission of peritoneal dissemination of colon cancer by alternate‑day S‑1 and oxaliplatin plus bevacizumab treatment and maintenance chemotherapy comprising alternate‑day S‑1 plus bevacizumab: A case report

  • Authors:
    • Nobuhiro Nitori
    • Ayu Kato
    • Tomoaki Deguchi
    • Jumpei Nakadai
    • Ayako Tada
    • Makoto Takahashi
    • Rumiko Umeda
    • Naoteru Miyata
    • Mikinori Kataoka
    • Tomohisa Kadomura
    • Hajime Higuchi
    • Hirotoshi Ebinuma
    • Atsushi Kato
    • Takashi Hatori
    • Yoshifumi Ikeda
    • Masaru Miyazaki
  • View Affiliations / Copyright

    Affiliations: Center of Digestive Diseases, International University of Health and Welfare, Mita Hospital, Tokyo 108‑8329, Japan
  • Pages: 270-274
    |
    Published online on: December 11, 2018
       https://doi.org/10.3892/mco.2018.1791
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

A 56‑year‑old man diagnosed with sigmoid colon cancer underwent sigmoid colectomy. Nine months later, his serum carcinoembryonic antigen (CEA) level had increased, and the diagnosis of recurrent peritoneal dissemination was made based on positron emission tomography/computed tomography (PET/CT) findings. Although systemic chemotherapy comprising S‑1 and oxaliplatin (SOX) plus bevacizumab was initiated, severe diarrhea occurred on day 4 of the second cycle despite reduction in S‑1 dose. By changing the daily oral intake schedule for S‑1 to an alternate‑day intake from the third cycle (modified SOX plus bevacizumab), the patient was able to continue undergoing chemotherapy without any adverse gastrointestinal effects. All tumors disappeared after four cycles, and the patients received eight cycles of modified SOX plus bevacizumab followed by maintenance chemotherapy comprising alternate‑day S‑1 plus bevacizumab. Maintenance chemotherapy was discontinued after 17 cycles owing to adverse events, including thrombocytopenia, corneal and lacrimal duct disorders, and hyperbilirubinemia. The patient has been radiographically confirmed to be in remission for 5 years without any recurrence, and his serum CEA level has been within normal range for >3 years. To conclude, compared with the conventional consecutive treatment, alternate‑day SOX plus bevacizumab treatment may reduce the adverse effects of these chemotherapeutic drugs.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

van Gestel YR, Thomassen I, Lemmens VE, Pruijt JF, van Herk-Sukel MP, Rutten HJ, Creemers GJ and de Hingh IH: Metachronous peritoneal carcinomatosis after curative treatment of colorectal cancer. Eur J Surg Oncol. 40:963–969. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Franko J, Shi Q, Goldman CD, Pockaj BA, Nelson GD, Goldberg RM, Pitot HC, Grothey A, Alberts SR and Sargent DJ: Treatment of colorectal peritoneal carcinomatosis with systemic chemotherapy: A pooled analysis of north central cancer treatment group phase III trials N9741 and N9841. J Clin Oncol. 30:263–267. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Razenberg LG, van Gestel YR, Lemmens VE, de Hingh IH and Creemers GJ: Bevacizumab in addition to palliative chemotherapy for patients with peritoneal carcinomatosis of colorectal origin: A nationwide population-based study. Clin Colorectal Cancer. 15:e41–e46. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Yamada Y, Takahari D, Matsumoto H, Baba H, Nakamura M, Yoshida K, Yoshida M, Iwamoto S, Shimada K, Komatsu Y, et al: Leucovorin, fluorouracil, and oxaliplatin plus bevacizumab versus S-1 and oxaliplatin plus bevacizumab in patients with metastatic colorectal cancer (SOFT): An open-label, non-inferiority, randomised phase 3 trial. Lancet Oncol. 14:1278–1286. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Shirasaka T: Development history and concept of an oral anticancer agent S-1 (TS-1): Its clinical usefulness and future vistas. Jpn J Clin Oncol. 39:2–15. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Arai W, Hosoya Y, Hyodo M, Yokoyama T, Hirashima Y, Yasuda Y, Nagai H and Shirasaka T: Alternate-day oral therapy with TS-1 for advanced gastric cancer. Int J Clin Oncol. 9:143–148. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Arai W, Hosoya Y, Haruta H, Kurashina K, Saito S, Hirashima Y, Yokoyama T, Zuiki T, Sakuma K, Hyodo M, et al: Comparison of alternate-day versus consecutive-day treatment with S-1: Assessment of tumor growth inhibition and toxicity reduction in gastric cancer cell lines in vitro and in vivo. Int J Clin Oncol. 13:515–520. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Tatebe S, Tsujitani S, Nakamura S, Shimizu T, Yamane N, Nishidoi H, Kurisu Y, Kanayama H, Ogawa H and Ikeguchi M: Feasibility study of alternate-day S-1 as adjuvant chemotherapy for gastric cancer: A randomized controlled trial. Gastric Cancer. 17:508–513. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Kim ST, Hong YS, Lim HY, Lee J, Kim TW, Kim KP, Kim SY, Baek JY, Kim JH, Lee KW, et al: S-1 plus oxaliplatin versus capecitabine plus oxaliplatin for the first-line treatment of patients with metastatic colorectal cancer: Updated results from a phase 3 trial. BMC Cancer. 14:8832014. View Article : Google Scholar : PubMed/NCBI

10 

Hong YS, Park YS, Lim HY, Lee J, Kim TW, Kim KP, Kim SY, Baek JY, Kim JH, Lee KW, et al: S-1 plus oxaliplatin versus capecitabine plus oxaliplatin for first-line treatment of patients with metastatic colorectal cancer: A randomised, non-inferiority phase 3 trial. Lancet Oncol. 13:1125–1132. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Shirasaka T, Shimamoto Y and Fukushima M: Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats. Cancer Res. 53:4004–4009. 1993.PubMed/NCBI

12 

Matsuda C, Uemura M, Nakata K, Shingai T, Nishimura J, Hata T, Ikenaga M, Takemasa I, Mizushima T, Kato T, et al: Randomized phase II study of S-1 dosing schedule for resected colorectal cancer. BMC Cancer. 15:4522015. View Article : Google Scholar : PubMed/NCBI

13 

Chibaudel B, Maindrault-Goebel F, Lledo G, Mineur L, André T, Bennamoun M, Mabro M, Artru P, Carola E, Flesch M, et al: Can chemotherapy be discontinued in unresectable metastatic colorectal cancer? The GERCOR OPTIMOX2 Study. J Clin Oncol. 27:5727–5733. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Goey KKH, Elias SG, van Tinteren H, Laclé MM, Willems SM, Offerhaus GJA, de Leng WWJ, Strengman E, Ten Tije AJ, Creemers GM, et al: Maintenance treatment with capecitabine and bevacizumab versus observation in metastatic colorectal cancer: Updated results and molecular subgroup analyses of the phase 3 CAIRO3 study. Ann Oncol. 28:2128–2134. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Dy GK, Krook JE, Green EM, Sargent DJ, Delaunoit T, Morton RF, Fuchs CS, Ramanathan RK, Williamson SK, Findlay BP, et al: Intergroup N9741: Impact of complete response to chemotherapy on overall survival in advanced colorectal cancer: Results from Intergroup N9741. J Clin Oncol. 25:3469–3474. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Wang WS, Lin JK, Lin TC, Chiou TJ, Liu JH, Yen CC, Chen WS, Jiang JK, Yang SH, Wang HS, et al: Tumor marker CEA in monitoring of response to tegafur-uracil and folinic acid in patients with metastatic colorectal cancer. Hepatogastroenterology. 49:388–392. 2002.PubMed/NCBI

17 

Satoh Y, Ichikawa T, Motosugi U, Kimura K, Sou H, Sano K and Araki T: Diagnosis of peritoneal dissemination: Comparison of 18F-FDG PET/CT, diffusion-weighted MRI, and contrast-enhanced MDCT. AJR Am J Roentgenol. 196:447–453. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Patel CM, Sahdev A and Reznek RHCT: CT, MRI and PET imaging in peritoneal malignancy. Cancer Imaging. 11:123–139. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Kishiki T, Lapin B, Matsuoka H, Watanabe T, Takayasu K, Kojima K, Sugihara K and Masaki T: Optimal surveillance protocols after curative resection in patients with stage IV colorectal cancer: A multicenter retrospective study. Dis Colon Rectum. 61:51–57. 2018.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nitori N, Kato A, Deguchi T, Nakadai J, Tada A, Takahashi M, Umeda R, Miyata N, Kataoka M, Kadomura T, Kadomura T, et al: Complete remission of peritoneal dissemination of colon cancer by alternate‑day S‑1 and oxaliplatin plus bevacizumab treatment and maintenance chemotherapy comprising alternate‑day S‑1 plus bevacizumab: A case report. Mol Clin Oncol 10: 270-274, 2019.
APA
Nitori, N., Kato, A., Deguchi, T., Nakadai, J., Tada, A., Takahashi, M. ... Miyazaki, M. (2019). Complete remission of peritoneal dissemination of colon cancer by alternate‑day S‑1 and oxaliplatin plus bevacizumab treatment and maintenance chemotherapy comprising alternate‑day S‑1 plus bevacizumab: A case report. Molecular and Clinical Oncology, 10, 270-274. https://doi.org/10.3892/mco.2018.1791
MLA
Nitori, N., Kato, A., Deguchi, T., Nakadai, J., Tada, A., Takahashi, M., Umeda, R., Miyata, N., Kataoka, M., Kadomura, T., Higuchi, H., Ebinuma, H., Kato, A., Hatori, T., Ikeda, Y., Miyazaki, M."Complete remission of peritoneal dissemination of colon cancer by alternate‑day S‑1 and oxaliplatin plus bevacizumab treatment and maintenance chemotherapy comprising alternate‑day S‑1 plus bevacizumab: A case report". Molecular and Clinical Oncology 10.2 (2019): 270-274.
Chicago
Nitori, N., Kato, A., Deguchi, T., Nakadai, J., Tada, A., Takahashi, M., Umeda, R., Miyata, N., Kataoka, M., Kadomura, T., Higuchi, H., Ebinuma, H., Kato, A., Hatori, T., Ikeda, Y., Miyazaki, M."Complete remission of peritoneal dissemination of colon cancer by alternate‑day S‑1 and oxaliplatin plus bevacizumab treatment and maintenance chemotherapy comprising alternate‑day S‑1 plus bevacizumab: A case report". Molecular and Clinical Oncology 10, no. 2 (2019): 270-274. https://doi.org/10.3892/mco.2018.1791
Copy and paste a formatted citation
x
Spandidos Publications style
Nitori N, Kato A, Deguchi T, Nakadai J, Tada A, Takahashi M, Umeda R, Miyata N, Kataoka M, Kadomura T, Kadomura T, et al: Complete remission of peritoneal dissemination of colon cancer by alternate‑day S‑1 and oxaliplatin plus bevacizumab treatment and maintenance chemotherapy comprising alternate‑day S‑1 plus bevacizumab: A case report. Mol Clin Oncol 10: 270-274, 2019.
APA
Nitori, N., Kato, A., Deguchi, T., Nakadai, J., Tada, A., Takahashi, M. ... Miyazaki, M. (2019). Complete remission of peritoneal dissemination of colon cancer by alternate‑day S‑1 and oxaliplatin plus bevacizumab treatment and maintenance chemotherapy comprising alternate‑day S‑1 plus bevacizumab: A case report. Molecular and Clinical Oncology, 10, 270-274. https://doi.org/10.3892/mco.2018.1791
MLA
Nitori, N., Kato, A., Deguchi, T., Nakadai, J., Tada, A., Takahashi, M., Umeda, R., Miyata, N., Kataoka, M., Kadomura, T., Higuchi, H., Ebinuma, H., Kato, A., Hatori, T., Ikeda, Y., Miyazaki, M."Complete remission of peritoneal dissemination of colon cancer by alternate‑day S‑1 and oxaliplatin plus bevacizumab treatment and maintenance chemotherapy comprising alternate‑day S‑1 plus bevacizumab: A case report". Molecular and Clinical Oncology 10.2 (2019): 270-274.
Chicago
Nitori, N., Kato, A., Deguchi, T., Nakadai, J., Tada, A., Takahashi, M., Umeda, R., Miyata, N., Kataoka, M., Kadomura, T., Higuchi, H., Ebinuma, H., Kato, A., Hatori, T., Ikeda, Y., Miyazaki, M."Complete remission of peritoneal dissemination of colon cancer by alternate‑day S‑1 and oxaliplatin plus bevacizumab treatment and maintenance chemotherapy comprising alternate‑day S‑1 plus bevacizumab: A case report". Molecular and Clinical Oncology 10, no. 2 (2019): 270-274. https://doi.org/10.3892/mco.2018.1791
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team