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Radical and testis‑sparing surgery for primary testicular tumors: A single‑center experience

  • Authors:
    • Fang Xiao
    • Jia‑Zi Shi
    • Yang Liu
    • Tao Liu
    • Jie Wang
    • Yu‑Shan Liu
    • Jun‑Kai Wang
    • Lin‑Hui Wang
  • View Affiliations / Copyright

    Affiliations: Department of Urology and Andrology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 343-351
    |
    Published online on: December 18, 2018
       https://doi.org/10.3892/mco.2018.1794
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Abstract

The aim of the present study was to assess the oncological and functional outcomes of testis‑sparing surgery (TSS) for testicular tumors compared with radical orchiectomy (RO) in a single center. A retrospective comparative cohort study was conducted in Changzheng Hospital. Patients were identified using the hospital information system from January 1999 to December 2016, collecting all of the data regarding clinical, treatment and prognostic profiles. Patient follow‑up was also executed to obtain information on patients' survival status, serum markers profiles, disease progression, androgen substitution requirement and paternity status. In total 158 patients were enrolled into the cohort study, including 23 TSS cases. The TSS procedure was primarily conducted in younger patients (average age, 31.9 vs. 47.7 years) or those with smaller tumors (average tumor diameter, 26.0 vs. 51.5 mm). The overall survival and recurrence free survival revealed no differences in the two groups, suggesting similar oncological outcomes. Kaplan‑Maier analysis demonstrated a higher cumulative paternity rate in the TSS group than in RO group, indicating a possible advantage of preserving patients' fertility in TSS over RO. TSS with proper adjuvant therapies proved to be a promising alternative in the avoidance of emasculation, infertility, life‑long androgen substitution and other psychosexual difficulties, as the oncological outcomes were not inferior to RO in the selected cases. However, further investigation is required in order to assess its oncological and functional values.
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1 

Bazzi WM, Raheem OA, Stroup SP, Kane CJ, Derweesh IH and Downs TM: Partial orchiectomy and testis intratubular germ cell neoplasia: World literature review. Urol Ann. 3:115–118. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Heidenreich A and Angerer-Shpilenya M: Organ-preserving surgery for testicular tumours. BJU Int. 109:474–490. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Heidenreich A, Weissbach L, Höltl W, Albers P, Kliesch S, Köhrmann KU and DIeckmann KP; German Testicular Cancer Study Group, : Organ sparing surgery for malignant germ cell tumor of the testis. J Urol. 166:2161–2165. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Patel AS, Coley BD and Jayanthi VR: Ultrasonography underestimates the volume of normal parenchyma in benign testicular masses. J Urol. 178:1730–1732. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Ferretti L, Sargos P, Gross-Goupil M, Izard V, Wallerand H, Huyghe E, Rigot JM, Durand X, Benoit G, Ferriere JM, et al: Testicular-sparing surgery for bilateral or monorchide testicular tumours: A multicenter study of long-term oncological and functional results. BJU Int. 114:860–864. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Sabanegh ES Jr and Ragheb AM: Male fertility after cancer. Urology. 73:225–231. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Fosså SD, Opjordsmoen S and Haug E: Androgen replacement and quality of life in patients treated for bilateral testicular cancer. Eur J Cancer. 35:1220–1225. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Williams DH IV, Karpman E, Sander JC, Spiess PE, Pisters LL and Lipshultz LI: Pretreatment semen parameters in men with cancer. J Urol. 181:736–740. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Jacobsen KD, Theodorsen L and Fossa SD: Spermatogenesis after unilateral orchiectomy for testicular cancer in patients following surveillance policy. J Urol. 165:93–96. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Heidenreich A, Thüer D and Polyakov S: Postchemotherapy retroperitoneal lymph node dissection in advanced germ cell tumours of the testis. Eur Urol. 53:260–272. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Allen JC, Kirschner A, Scarpato KR and Morgans AK: Current management of refractory germ cell tumors and future directions. Curr Oncol Rep. 19:82017. View Article : Google Scholar : PubMed/NCBI

14 

Giannarini G, Dieckmann KP, Albers P, Heidenreich A and Pizzocaro G: Organ-sparing surgery for adult testicular tumours: A systematic review of the literature. Eur Urol. 57:780–790. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Petersen PM, Giwercman A, Daugaard G, Rørth M, Petersen JH, Skakkeaek NE, Hansen SW and von der Maase H: Effect of graded testicular doses of radiotherapy in patients treated for carcinoma-in-situ in the testis. J Clin Oncol. 20:1537–1543. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Feldman DR, Bosl GJ, Sheinfeld J and Motzer RJ: Medical treatment of advanced testicular cancer. JAMA. 299:672–684. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Fosså SD, Horwich A, Russell JM, Roberts JT, Cullen MH, Hodson NJ, Jones WG, Yosef H, Duchesne GM, Owen JR, et al Medical Research Council Testicular Tumor Working Group, : Optimal planning target volume for stage I testicular seminoma: A Medical Research Council randomized trial. J Clin Oncol. 17:11461999. View Article : Google Scholar : PubMed/NCBI

18 

Brydøy M, Fosså SD, Klepp O, Bremnes RM, Wist EA, Wentzel-Larsen T and Dahl O: Paternity following treatment for testicular cancer. J Natl Cancer Inst. 97:1580–1588. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Lackner JE, Koller A, Schatzl G, Marberger M and Kratzik C: Androgen deficiency symptoms in testicular cancer survivors are associated with sexual problems but not with serum testosterone or therapy. Urology. 74:825–829. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Krege S, Beyer J, Souchon R, Albers P, Albrecht W, Algaba F, Bamberg M, Bodrogi I, Bokemeyer C, Cavallin-Ståhl E, et al: European consensus conference on diagnosis and treatment of germ cell cancer: A report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I. Eur Urol. 53:478–496. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Woo LL and Ross JH: The role of testis-sparing surgery in children and adolescents with testicular tumors. Urol Oncol. 34:76–83. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Pohl HG, Shukla AR, Metcalf PD, Cilento BG, Retik AB, Bagli DJ, Huff DS and Rushton HG: Prepubertal testis tumors: Actual prevalence rate of histological types. J Urol. 172:2370–2372. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Galosi AB, Fulvi P, Fabiani A, Servi L, Filosa A, Leone L, Marronaro A, Caraceni E and Montironi R: Testicular sparing surgery in small testis masses: A multinstitutional experience. Arch Ital Urol Androl. 88:320–324. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Ye YL, He QM, Zheng FF, Guo SJ, Zhou FJ and Qin ZK: Trends of testis-sparing surgery for pediatric testicular tumors in South China. BMC Surg. 17:312017. View Article : Google Scholar : PubMed/NCBI

25 

Keske M, Canda AE, Yalcin S, Kilicarslan A, Kibar Y, Tuygun C, Onder E, Atmaca AF, Yildirim A, Ozkanli SS, et al: Is testis-sparing surgery safe in small testicular masses? Results of a multicentre study. Can Urol Assoc J. 11:E100–100E104. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Bojanic N, Bumbasirevic U, Bojanic G, Vukovic I, Milojevic B and Pekmezovic T: Testis sparing surgery for treatment of small testicular lesions: Is it feasible even in germ cell tumors? J Surg Oncol. 115:287–290. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xiao F, Shi JZ, Liu Y, Liu T, Wang J, Liu YS, Wang JK and Wang LH: Radical and testis‑sparing surgery for primary testicular tumors: A single‑center experience. Mol Clin Oncol 10: 343-351, 2019.
APA
Xiao, F., Shi, J., Liu, Y., Liu, T., Wang, J., Liu, Y. ... Wang, L. (2019). Radical and testis‑sparing surgery for primary testicular tumors: A single‑center experience. Molecular and Clinical Oncology, 10, 343-351. https://doi.org/10.3892/mco.2018.1794
MLA
Xiao, F., Shi, J., Liu, Y., Liu, T., Wang, J., Liu, Y., Wang, J., Wang, L."Radical and testis‑sparing surgery for primary testicular tumors: A single‑center experience". Molecular and Clinical Oncology 10.3 (2019): 343-351.
Chicago
Xiao, F., Shi, J., Liu, Y., Liu, T., Wang, J., Liu, Y., Wang, J., Wang, L."Radical and testis‑sparing surgery for primary testicular tumors: A single‑center experience". Molecular and Clinical Oncology 10, no. 3 (2019): 343-351. https://doi.org/10.3892/mco.2018.1794
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao F, Shi JZ, Liu Y, Liu T, Wang J, Liu YS, Wang JK and Wang LH: Radical and testis‑sparing surgery for primary testicular tumors: A single‑center experience. Mol Clin Oncol 10: 343-351, 2019.
APA
Xiao, F., Shi, J., Liu, Y., Liu, T., Wang, J., Liu, Y. ... Wang, L. (2019). Radical and testis‑sparing surgery for primary testicular tumors: A single‑center experience. Molecular and Clinical Oncology, 10, 343-351. https://doi.org/10.3892/mco.2018.1794
MLA
Xiao, F., Shi, J., Liu, Y., Liu, T., Wang, J., Liu, Y., Wang, J., Wang, L."Radical and testis‑sparing surgery for primary testicular tumors: A single‑center experience". Molecular and Clinical Oncology 10.3 (2019): 343-351.
Chicago
Xiao, F., Shi, J., Liu, Y., Liu, T., Wang, J., Liu, Y., Wang, J., Wang, L."Radical and testis‑sparing surgery for primary testicular tumors: A single‑center experience". Molecular and Clinical Oncology 10, no. 3 (2019): 343-351. https://doi.org/10.3892/mco.2018.1794
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