Expression of keratin 15 in dentigerous cyst, odontogenic keratocyst and ameloblastoma

Alsaegh,Mohammed  Amjed; Altaie,Alaa  Muayad; Zhu,Shengrong

doi:10.3892/mco.2019.1802

Expression of keratin 15 in dentigerous cyst, odontogenic keratocyst and ameloblastoma

Authors:
- Mohammed Amjed Alsaegh
- Alaa Muayad Altaie
- Shengrong Zhu
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Affiliations: Department of Oral and Maxillofacial Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Sharjah Medical Research Institute, Medical College, Sharjah University, Sharjah 27272, United Arab Emirates
Published online on: January 17, 2019 https://doi.org/10.3892/mco.2019.1802
Pages: 377-381

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Abstract

The etiology and pathogenesis of odontogenic lesions are poorly understood. Keratin 15 (K15) is a type I cytoskeletal protein that provides structural support to the cells and has been considered to be a stem cell marker. The aim of the present study was to evaluate the expression of K15 in the epithelial lining of dentigerous cysts (DCs), odontogenic keratocysts (OKCs) and ameloblastomas (ABs). The study included 41 samples of DCs (n=13), OKCs (n=12), and AB tissues (n=16). K15 protein expression was evaluated via immunohistochemistry and data were statistically analyzed using a Kruskal‑Wallis test. K15 was expressed in the majority of the studied lesions with various distributions in the different study samples. The Kruskal‑Wallis test revealed non‑significant differences in the expression of K15 among the three odontogenic lesions (P=0.380). The present study confirmed the high expression of K15 in the different epithelial layers of DC, OKC and AB. This type of expression excludes the reliability of regarding K15 as a stem cell marker in DC, OKC and AB. However, K15 may reflect the abnormal differentiation of pathological epithelial cells in these lesions.

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