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Article

Relationship between serum inflammatory cytokines and lifestyle factors in gastric cancer

  • Authors:
    • Xian Sun
    • Chun‑Jie Xiang
    • Juan Wu
    • Wei Dong
    • Zhen Zhan
    • Rui‑Ping Wang
    • Jun‑Feng Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Pathogen and Immunology, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, Department of Oncology, First Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 401-414
    |
    Published online on: January 22, 2019
       https://doi.org/10.3892/mco.2019.1804
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Abstract

Chronic inflammation is associated with increased risk of gastric cancer (GC), and GC risk is significantly associated with lifestyle. The aim of the present study was to explore the association between serum inflammatory cytokines and lifestyle factors in GC. A total of 20 serum inflammatory cytokines were measured in a hospital‑based case‑control population with 142 GC patients and 98 healthy controls. Controls without the selected healthy lifestyle factors were regarded as baseline, and correlation analysis was conducted to establish the association between serum inflammatory cytokines and lifestyle factors. The results demonstrated that several lifestyle factors (including eating fried and salty foods, eating quickly, smoking and drinking) could increase the risk of GC, while only eating fresh fruits could decrease the risk of GC. Correlation analysis revealed that increased serum interleukin (IL)‑12/IL‑23P40 levels was associated with GC risk as significant differences were observed in all lifestyle factors. Increased serum IL‑8 was closely associated with smoking in GC patients, while increased IL‑17α and IL‑8 levels were associated with GC patients who ate salty foods. Increased IL‑10 and decreased TGF‑β levels were also associated with GC patients who ate fresh fruits. In conclusion, GC risk was strongly affected by lifestyle factors, which may regulate the expression of inflammatory cytokines and promote gastric carcinogenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Sun X, Xiang CJ, Wu J, Dong W, Zhan Z, Wang RP and Zhang JF: Relationship between serum inflammatory cytokines and lifestyle factors in gastric cancer. Mol Clin Oncol 10: 401-414, 2019.
APA
Sun, X., Xiang, C., Wu, J., Dong, W., Zhan, Z., Wang, R., & Zhang, J. (2019). Relationship between serum inflammatory cytokines and lifestyle factors in gastric cancer. Molecular and Clinical Oncology, 10, 401-414. https://doi.org/10.3892/mco.2019.1804
MLA
Sun, X., Xiang, C., Wu, J., Dong, W., Zhan, Z., Wang, R., Zhang, J."Relationship between serum inflammatory cytokines and lifestyle factors in gastric cancer". Molecular and Clinical Oncology 10.3 (2019): 401-414.
Chicago
Sun, X., Xiang, C., Wu, J., Dong, W., Zhan, Z., Wang, R., Zhang, J."Relationship between serum inflammatory cytokines and lifestyle factors in gastric cancer". Molecular and Clinical Oncology 10, no. 3 (2019): 401-414. https://doi.org/10.3892/mco.2019.1804
Copy and paste a formatted citation
x
Spandidos Publications style
Sun X, Xiang CJ, Wu J, Dong W, Zhan Z, Wang RP and Zhang JF: Relationship between serum inflammatory cytokines and lifestyle factors in gastric cancer. Mol Clin Oncol 10: 401-414, 2019.
APA
Sun, X., Xiang, C., Wu, J., Dong, W., Zhan, Z., Wang, R., & Zhang, J. (2019). Relationship between serum inflammatory cytokines and lifestyle factors in gastric cancer. Molecular and Clinical Oncology, 10, 401-414. https://doi.org/10.3892/mco.2019.1804
MLA
Sun, X., Xiang, C., Wu, J., Dong, W., Zhan, Z., Wang, R., Zhang, J."Relationship between serum inflammatory cytokines and lifestyle factors in gastric cancer". Molecular and Clinical Oncology 10.3 (2019): 401-414.
Chicago
Sun, X., Xiang, C., Wu, J., Dong, W., Zhan, Z., Wang, R., Zhang, J."Relationship between serum inflammatory cytokines and lifestyle factors in gastric cancer". Molecular and Clinical Oncology 10, no. 3 (2019): 401-414. https://doi.org/10.3892/mco.2019.1804
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