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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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April-2019 Volume 10 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Undifferentiated carcinoma of the oral tongue treated with cetuximab: A case report

  • Authors:
    • Yuki Sakamoto
    • Souichi Yanamoto
    • Masaki Adachi
    • Shoma Tsuda
    • Kohei Furukawa
    • Tomofumi Naruse
    • Masahiro Umeda
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Oral Oncology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852‑8588, Japan
  • Pages: 446-450
    |
    Published online on: February 4, 2019
       https://doi.org/10.3892/mco.2019.1808
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Abstract

Undifferentiated carcinoma of the oral cavity is a rare and possibly fatal malignant neoplasm. We present here a case of undifferentiated carcinoma of the oral tongue, which responded well to chemotherapy with cisplatin, 5‑fluorouracil, and cetuximab. A 59‑year‑old man was referred to our hospital for a large tumor of the tongue. Physical examination revealed an ulcerative tumor, approximately 50 mm in diameter, on the right edge of the tongue and swelling of multiple cervical lymph nodes; therefore, the clinical diagnosis was tongue cancer (T4aN2bM0). The histological diagnosis from a biopsy specimen was undifferentiated carcinoma; we tested the sample for human papilloma virus immunoreactivity, which was positive. The patient then underwent chemotherapy with cisplatin, 5‑fluorouracil and cetuximab. The tumor's size decreased markedly after two courses of chemotherapy, but the treatment was stopped due to the patient' various mental problems and pneumonia; he died 6 months after the initial visit. Our encounter with this patient suggests that cetuximab treatment is a good option for HPV‑positive undifferentiated carcinoma of the oral tongue.
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Copy and paste a formatted citation
Spandidos Publications style
Sakamoto Y, Yanamoto S, Adachi M, Tsuda S, Furukawa K, Naruse T and Umeda M: Undifferentiated carcinoma of the oral tongue treated with cetuximab: A case report. Mol Clin Oncol 10: 446-450, 2019.
APA
Sakamoto, Y., Yanamoto, S., Adachi, M., Tsuda, S., Furukawa, K., Naruse, T., & Umeda, M. (2019). Undifferentiated carcinoma of the oral tongue treated with cetuximab: A case report. Molecular and Clinical Oncology, 10, 446-450. https://doi.org/10.3892/mco.2019.1808
MLA
Sakamoto, Y., Yanamoto, S., Adachi, M., Tsuda, S., Furukawa, K., Naruse, T., Umeda, M."Undifferentiated carcinoma of the oral tongue treated with cetuximab: A case report". Molecular and Clinical Oncology 10.4 (2019): 446-450.
Chicago
Sakamoto, Y., Yanamoto, S., Adachi, M., Tsuda, S., Furukawa, K., Naruse, T., Umeda, M."Undifferentiated carcinoma of the oral tongue treated with cetuximab: A case report". Molecular and Clinical Oncology 10, no. 4 (2019): 446-450. https://doi.org/10.3892/mco.2019.1808
Copy and paste a formatted citation
x
Spandidos Publications style
Sakamoto Y, Yanamoto S, Adachi M, Tsuda S, Furukawa K, Naruse T and Umeda M: Undifferentiated carcinoma of the oral tongue treated with cetuximab: A case report. Mol Clin Oncol 10: 446-450, 2019.
APA
Sakamoto, Y., Yanamoto, S., Adachi, M., Tsuda, S., Furukawa, K., Naruse, T., & Umeda, M. (2019). Undifferentiated carcinoma of the oral tongue treated with cetuximab: A case report. Molecular and Clinical Oncology, 10, 446-450. https://doi.org/10.3892/mco.2019.1808
MLA
Sakamoto, Y., Yanamoto, S., Adachi, M., Tsuda, S., Furukawa, K., Naruse, T., Umeda, M."Undifferentiated carcinoma of the oral tongue treated with cetuximab: A case report". Molecular and Clinical Oncology 10.4 (2019): 446-450.
Chicago
Sakamoto, Y., Yanamoto, S., Adachi, M., Tsuda, S., Furukawa, K., Naruse, T., Umeda, M."Undifferentiated carcinoma of the oral tongue treated with cetuximab: A case report". Molecular and Clinical Oncology 10, no. 4 (2019): 446-450. https://doi.org/10.3892/mco.2019.1808
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