Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
April-2019 Volume 10 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2019 Volume 10 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Factors affecting healing time of postoperative pancreatic fistula in patients undergoing pancreaticoduodenectomy

  • Authors:
    • Yoshito Tomimaru
    • Kozo Noguchi
    • Shingo Noura
    • Hiroshi Imamura
    • Takashi Iwazawa
    • Keizo Dono
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Toyonaka Municipal Hospital, Toyonaka, Osaka 560-8565, Japan
  • Pages: 435-440
    |
    Published online on: February 21, 2019
       https://doi.org/10.3892/mco.2019.1812
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Clinically‑relevant postoperative pancreatic fistula (CR‑POPF) is one of the most serious complications following pancreaticoduodenectomy. While many investigators have studied risk factors for the development of CR‑POPF, few studies have focused on time needed for CR‑POPF healing in patients who develop this complication. The present study enrolled 38 cases in whom CR‑POPF developed following pancreaticoduodenectomy (24.1%) out of 158 cases receiving treatment with pancreaticoduodenectomy between 2009 and 2017 for periampullary diseases. CR‑POPF healing time, was defined as the length of time from the day of pancreaticoduodenectomy to the day when intraabdominal drainage tubes used for CR‑POPF treatment were removed, were assessed and factors affecting the healing time were investigated. The mean CR‑POPF healing time was 40.2±21.7 days (median; 35 days, range; 10‑110 days). Univariate analysis demonstrated a significant relationship between CP‑POPE healing time and sex, intraoperative blood loss, and type of pancreaticojejunostomy procedure. Multivariate Cox regression analysis using these factors revealed that intraoperative blood loss and type of pancreaticojejunostomy procedure were significant independent factors for the length of CR‑POPF healing time. CR‑POPF healing time following pancreaticoduodenectomy was 40.2±21.7 days on average (median, 35 days; range 10‑110 days). Intraoperative blood loss and type of pancreaticojejunostomy procedure were identified as significant independent factors associated with the healing time. These results will help with earlier recovery from CR‑POPF.
View Figures

Figure 1

Figure 2

View References

1 

de Castro SM, Busch OR, van Gulik TM, Obertop H and Gouma DJ: Incidence and management of pancreatic leakage after pancreatoduodenectomy. Br J Surg. 92:1117–1123. 2005. View Article : Google Scholar

2 

Kirihara Y, Takahashi N, Hashimoto Y, Sclabas GM, Khan S, Moriya T, Sakagami J, Huebner M, Sarr MG and Farnell MB: Prediction of pancreatic anastomotic failure after pancreatoduodenectomy: The use of preoperative, quantitative computed tomography to measure remnant pancreatic volume and body composition. Ann Surg. 257:512–519. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Fu SJ, Shen SL, Li SQ, Hu WJ, Hua YP, Kuang M, Liang LJ and Peng BG: Risk factors and outcomes of postoperative pancreatic fistula after pancreatico-duodenectomy: An audit of 532 consecutive cases. BMC Surg. 15:342015. View Article : Google Scholar : PubMed/NCBI

4 

Hashimoto Y and Traverso LW: Pancreatic anastomotic failure rate after pancreaticoduodenectomy decreases with microsurgery. J Am Coll Surg. 211:510–521. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Pecorelli N, Balzano G, Capretti G, Zerbi A, Di Carlo V and Braga M: Effect of surgeon volume on outcome following pancreaticoduodenectomy in a high-volume hospital. J Gastrointest Surg. 16:518–523. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Poon RT, Fan ST, Lo CM, Ng KK, Yuen WK, Yeung C and Wong J: External drainage of pancreatic duct with a stent to reduce leakage rate of pancreaticojejunostomy after pancreaticoduodenectomy: A prospective randomized trial. Ann Surg. 246:425–435. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Aoki S, Miyata H, Konno H, Gotoh M, Motoi F, Kumamaru H, Wakabayashi G, Kakeji Y, Mori M, Seto Y, et al: Risk factors of serious postoperative complications after pancreaticoduodenectomy and risk calculators for predicting postoperative complications: A nationwide study of 17,564 patients in Japan. J Hepatobiliary Pancreat Sci. 24:243–251. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Gaujoux S, Cortes A, Couvelard A, Noullet S, Clavel L, Rebours V, Lévy P, Sauvanet A, Ruszniewski P and Belghiti J: Fatty pancreas and increased body mass index are risk factors of pancreatic fistula after pancreaticoduodenectomy. Surgery. 148:15–23. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Hu BY, Wan T, Zhang WZ and Dong JH: Risk factors for postoperative pancreatic fistula: Analysis of 539 successive cases of pancreaticoduodenectomy. World J Gastroenterol. 22:7797–7805. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Shubert CR, Wagie AE, Farnell MB, Nagorney DM, Que FG, Reid Lombardo KM, Truty MJ, Smoot RL and Kendrick ML: Clinical Risk Score to Predict Pancreatic Fistula after Pancreatoduodenectomy: Independent External Validation for Open and Laparoscopic Approaches. J Am Coll Surg. 221:689–698. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Tranchart H, Gaujoux S, Rebours V, Vullierme MP, Dokmak S, Levy P, Couvelard A, Belghiti J and Sauvanet A: Preoperative CT scan helps to predict the occurrence of severe pancreatic fistula after pancreaticoduodenectomy. Ann Surg. 256:139–145. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Fujii T, Sugimoto H, Yamada S, Kanda M, Suenaga M, Takami H, Hattori M, Inokawa Y, Nomoto S, Fujiwara M, et al: Modified Blumgart anastomosis for pancreaticojejunostomy: Technical improvement in matched historical control study. J Gastrointest Surg. 18:1108–1115. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Kakita A, Yoshida M and Takahashi T: History of pancreaticojejunostomy in pancreaticoduodenectomy: Development of a more reliable anastomosis technique. J Hepatobiliary Pancreat Surg. 8:230–237. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Bassi C, Marchegiani G, Dervenis C, Sarr M, Abu Hilal M, Adham M, Allen P, Andersson R, Asbun HJ, Besselink MG, et al International Study Group on Pancreatic Surgery (ISGPS), : The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After. Surgery. 161:584–591. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Onodera T, Goseki N and Kosaki G: Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients. Nihon Geka Gakkai Zasshi. 85:1001–1005. 1984.(In Japanese). PubMed/NCBI

16 

Kawai M, Kondo S, Yamaue H, Wada K, Sano K, Motoi F, Unno M, Satoi S, Kwon AH, Hatori T, et al: Predictive risk factors for clinically relevant pancreatic fistula analyzed in 1,239 patients with pancreaticoduodenectomy: Multicenter data collection as a project study of pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci. 18:601–608. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Yang H, Lu XF, Xu YF, Liu HD, Guo S, Liu Y and Chen YX: Application of air insufflation to prevent clinical pancreatic fistula after pancreaticoduodenectomy. World J Gastroenterol. 21:1872–1879. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Uesaka K, Boku N, Fukutomi A, Okamura Y, Konishi M, Matsumoto I, Kaneoka Y, Shimizu Y, Nakamori S, Sakamoto H, et al JASPAC 01 Study Group, : Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: A phase 3, open-label, randomised, non-inferiority trial (JASPAC 01). Lancet. 388:248–257. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Neoptolemos JP, Palmer DH, Ghaneh P, Psarelli EE, Valle JW, Halloran CM, Faluyi O, O'Reilly DA, Cunningham D, Wadsley J, et al European Study Group for Pancreatic Cancer, : Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): A multicentre, open-label, randomised, phase 3 trial. Lancet. 389:1011–1024. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tomimaru Y, Noguchi K, Noura S, Imamura H, Iwazawa T and Dono K: Factors affecting healing time of postoperative pancreatic fistula in patients undergoing pancreaticoduodenectomy. Mol Clin Oncol 10: 435-440, 2019.
APA
Tomimaru, Y., Noguchi, K., Noura, S., Imamura, H., Iwazawa, T., & Dono, K. (2019). Factors affecting healing time of postoperative pancreatic fistula in patients undergoing pancreaticoduodenectomy. Molecular and Clinical Oncology, 10, 435-440. https://doi.org/10.3892/mco.2019.1812
MLA
Tomimaru, Y., Noguchi, K., Noura, S., Imamura, H., Iwazawa, T., Dono, K."Factors affecting healing time of postoperative pancreatic fistula in patients undergoing pancreaticoduodenectomy". Molecular and Clinical Oncology 10.4 (2019): 435-440.
Chicago
Tomimaru, Y., Noguchi, K., Noura, S., Imamura, H., Iwazawa, T., Dono, K."Factors affecting healing time of postoperative pancreatic fistula in patients undergoing pancreaticoduodenectomy". Molecular and Clinical Oncology 10, no. 4 (2019): 435-440. https://doi.org/10.3892/mco.2019.1812
Copy and paste a formatted citation
x
Spandidos Publications style
Tomimaru Y, Noguchi K, Noura S, Imamura H, Iwazawa T and Dono K: Factors affecting healing time of postoperative pancreatic fistula in patients undergoing pancreaticoduodenectomy. Mol Clin Oncol 10: 435-440, 2019.
APA
Tomimaru, Y., Noguchi, K., Noura, S., Imamura, H., Iwazawa, T., & Dono, K. (2019). Factors affecting healing time of postoperative pancreatic fistula in patients undergoing pancreaticoduodenectomy. Molecular and Clinical Oncology, 10, 435-440. https://doi.org/10.3892/mco.2019.1812
MLA
Tomimaru, Y., Noguchi, K., Noura, S., Imamura, H., Iwazawa, T., Dono, K."Factors affecting healing time of postoperative pancreatic fistula in patients undergoing pancreaticoduodenectomy". Molecular and Clinical Oncology 10.4 (2019): 435-440.
Chicago
Tomimaru, Y., Noguchi, K., Noura, S., Imamura, H., Iwazawa, T., Dono, K."Factors affecting healing time of postoperative pancreatic fistula in patients undergoing pancreaticoduodenectomy". Molecular and Clinical Oncology 10, no. 4 (2019): 435-440. https://doi.org/10.3892/mco.2019.1812
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team