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Case Report Open Access

Management of primary squamous cell carcinoma of the pancreas with a nanosomal paclitaxel lipid suspension-based regimen: A case report

  • Authors:
    • Saroj Kumar Das Majumdar
    • Dillip Kumar Muduly
    • Subhasis Mishra
    • Chinmaya Rashmi Ranjan Mohapatra
    • Deepak Bunger
    • Mujtaba A. Khan
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy, All India Institute of Medical Sciences, Bhubaneswar, Odisha 751019, India, Department of Surgical Oncology, All India Institute of Medical Sciences, Bhubaneswar, Odisha 751019, India, Department of Medical Affairs and Clinical Development, Intas Pharmaceuticals Ltd., Ahmedabad, Gujarat 380054, India
    Copyright: © Majumdar et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Pages: 430-434
    |
    Published online on: February 22, 2019
       https://doi.org/10.3892/mco.2019.1814
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Abstract

Squamous cell carcinoma (SCC) of the pancreas is a rare tumor with only a few case reports available. It is an aggressive form of pancreatic cancer with a poor prognosis. The diagnosis and optimal management of SCC of the pancreas is poorly defined due to the lack of standard treatment or guidelines and owing to the rarity of this malignancy. Patients suffering from SCC of the pancreas do not respond well to chemotherapy or radiotherapy and isolated reports are available on the use of gemcitabine and newer taxane formulations. Surgical resection of the tumor is the most effective modality; however, due to a delay in diagnosis, the majority of pancreatic SCCs remain unresectable. Herein, a case of SCC of the pancreatic tail is reported in a 60‑year‑old patient who was managed with a combination of albumin‑free nanosomal paclitaxel lipid suspension (NPLS) and gemcitabine in a neoadjuvant setting. To the best of our knowledge, this is the first such case report of a locally advanced SCC of the pancreatic tail showing an overall survival of 1 year following treatment with an NPLS based regimen. The treatment was well tolerated with no serious safety concerns.
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Copy and paste a formatted citation
Spandidos Publications style
Majumdar SK, Muduly DK, Mishra S, Mohapatra CR, Bunger D and Khan MA: Management of primary squamous cell carcinoma of the pancreas with a nanosomal paclitaxel lipid suspension-based regimen: A case report. Mol Clin Oncol 10: 430-434, 2019.
APA
Majumdar, S.K., Muduly, D.K., Mishra, S., Mohapatra, C.R., Bunger, D., & Khan, M.A. (2019). Management of primary squamous cell carcinoma of the pancreas with a nanosomal paclitaxel lipid suspension-based regimen: A case report. Molecular and Clinical Oncology, 10, 430-434. https://doi.org/10.3892/mco.2019.1814
MLA
Majumdar, S. K., Muduly, D. K., Mishra, S., Mohapatra, C. R., Bunger, D., Khan, M. A."Management of primary squamous cell carcinoma of the pancreas with a nanosomal paclitaxel lipid suspension-based regimen: A case report". Molecular and Clinical Oncology 10.4 (2019): 430-434.
Chicago
Majumdar, S. K., Muduly, D. K., Mishra, S., Mohapatra, C. R., Bunger, D., Khan, M. A."Management of primary squamous cell carcinoma of the pancreas with a nanosomal paclitaxel lipid suspension-based regimen: A case report". Molecular and Clinical Oncology 10, no. 4 (2019): 430-434. https://doi.org/10.3892/mco.2019.1814
Copy and paste a formatted citation
x
Spandidos Publications style
Majumdar SK, Muduly DK, Mishra S, Mohapatra CR, Bunger D and Khan MA: Management of primary squamous cell carcinoma of the pancreas with a nanosomal paclitaxel lipid suspension-based regimen: A case report. Mol Clin Oncol 10: 430-434, 2019.
APA
Majumdar, S.K., Muduly, D.K., Mishra, S., Mohapatra, C.R., Bunger, D., & Khan, M.A. (2019). Management of primary squamous cell carcinoma of the pancreas with a nanosomal paclitaxel lipid suspension-based regimen: A case report. Molecular and Clinical Oncology, 10, 430-434. https://doi.org/10.3892/mco.2019.1814
MLA
Majumdar, S. K., Muduly, D. K., Mishra, S., Mohapatra, C. R., Bunger, D., Khan, M. A."Management of primary squamous cell carcinoma of the pancreas with a nanosomal paclitaxel lipid suspension-based regimen: A case report". Molecular and Clinical Oncology 10.4 (2019): 430-434.
Chicago
Majumdar, S. K., Muduly, D. K., Mishra, S., Mohapatra, C. R., Bunger, D., Khan, M. A."Management of primary squamous cell carcinoma of the pancreas with a nanosomal paclitaxel lipid suspension-based regimen: A case report". Molecular and Clinical Oncology 10, no. 4 (2019): 430-434. https://doi.org/10.3892/mco.2019.1814
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