Management of primary squamous cell carcinoma of the pancreas with a nanosomal paclitaxel lipid suspension-based regimen: A case report

Majumdar,Saroj  Kumar Das; Muduly,Dillip  Kumar; Mishra,Subhasis; Mohapatra,Chinmaya  Rashmi Ranjan; Bunger,Deepak; Khan,Mujtaba  A.

doi:10.3892/mco.2019.1814

Management of primary squamous cell carcinoma of the pancreas with a nanosomal paclitaxel lipid suspension-based regimen: A case report

Authors:
- Saroj Kumar Das Majumdar
- Dillip Kumar Muduly
- Subhasis Mishra
- Chinmaya Rashmi Ranjan Mohapatra
- Deepak Bunger
- Mujtaba A. Khan
View Affiliations

Affiliations: Department of Radiotherapy, All India Institute of Medical Sciences, Bhubaneswar, Odisha 751019, India, Department of Surgical Oncology, All India Institute of Medical Sciences, Bhubaneswar, Odisha 751019, India, Department of Medical Affairs and Clinical Development, Intas Pharmaceuticals Ltd., Ahmedabad, Gujarat 380054, India
Published online on: February 22, 2019 https://doi.org/10.3892/mco.2019.1814
Pages: 430-434
Copyright : © Majumdar et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Squamous cell carcinoma (SCC) of the pancreas is a rare tumor with only a few case reports available. It is an aggressive form of pancreatic cancer with a poor prognosis. The diagnosis and optimal management of SCC of the pancreas is poorly defined due to the lack of standard treatment or guidelines and owing to the rarity of this malignancy. Patients suffering from SCC of the pancreas do not respond well to chemotherapy or radiotherapy and isolated reports are available on the use of gemcitabine and newer taxane formulations. Surgical resection of the tumor is the most effective modality; however, due to a delay in diagnosis, the majority of pancreatic SCCs remain unresectable. Herein, a case of SCC of the pancreatic tail is reported in a 60‑year‑old patient who was managed with a combination of albumin‑free nanosomal paclitaxel lipid suspension (NPLS) and gemcitabine in a neoadjuvant setting. To the best of our knowledge, this is the first such case report of a locally advanced SCC of the pancreatic tail showing an overall survival of 1 year following treatment with an NPLS based regimen. The treatment was well tolerated with no serious safety concerns.

View Figures

View References

1	Pourhoseingholi MA, Ashtari S, Hajizadeh N, Fazeli Z and Zali MR: Systematic review of pancreatic cancer epidemiology in Asia-Pacific Region: Major patterns in GLOBACON 2012. Gastroenterol Hepatol Bed Bench. 10:245–257. 2017.PubMed/NCBI
2	Kamisawa T, Wood LD, Itoi T and Takaori K: Pancreatic cancer. Lancet. 388:73–85. 2016. View Article : Google Scholar : PubMed/NCBI
3	Lin HL, Kuo LC, Chen CW, Lin YK and Lee WC: Pancreatic tail cancer with sole manifestation of left flank pain: A very rare presentation. Kaohsiung J Med Sci. 24:324–327. 2008. View Article : Google Scholar : PubMed/NCBI
4	National Cancer Institute: Surveillance, epidemiology, and end results program. Cancer stat facts, . Pancreatic cancer. https://seer.cancer.gov/statfacts/html/pancreas.htmlJune 29–2018
5	Dhir V and Mohandas KM: Epidemiology of digestive tract cancers in India IV. Gall bladder and pancreas. Indian J Gastroenterol. 18:24–28. 1999.
6	Al-Shehri A, Silverman S and King KM: Squamous cell carcinoma of the pancreas. Curr Oncol. 15:293–297. 2008.PubMed/NCBI
7	Schultheis AM, Nguyen GP, Ortmann M, Kruis W, Büttner R, Schildhaus HU and Markiefka B: Squamous cell carcinoma of the pancreas in a patient with germline BRCA2 mutation-response to neoadjuvant radiochemotherapy. Case Rep Oncol Med. 2014:8605322014.PubMed/NCBI
8	Makarova-Rusher OV, Ulahannan S, Greten TF and Duffy A: Pancreatic squamous cell carcinoma: A population-based study of epidemiology, clinicopathologic characteristics and outcomes. Pancreas. 45:1432–1437. 2016. View Article : Google Scholar : PubMed/NCBI
9	Kodavatiganti R, Campbell F, Hashmi A and Gollins SW: Primary squamous cell carcinoma of the pancreas: A case report and review of the literature. J Med Case Reports. 6:295. 2012. View Article : Google Scholar
10	Mehta M, Sinha J, Ogawa M, Ganguly A, Xiang D and Poddar N: Unusual Case of Squamous Cell Carcinoma of Pancreas with Review of Literature. J Gastrointest Cancer. 46:426–429. 2015. View Article : Google Scholar : PubMed/NCBI
11	NCCN Clinical Practice Guidelines in Oncology. Pancreatic Adenocarcinoma. V1:2016, https://www.nccn.org/professionals/physician_gls/pdf/pancreatic.pdfJune 30–2018
12	Belli C, Cereda S and Reni M: Role of taxanes in pancreatic cancer. World J Gastroenterol. 18:4457–4465. 2012. View Article : Google Scholar : PubMed/NCBI
13	American Cancer Society: Signs and symptoms of pancreatic cancer. https://www.cancer.org/cancer/pancreatic-cancer/detection-diagnosis-staging/signs-and-symptoms.html28–February. 2018
14	Artinyan A, Soriano PA, Prendergast C, Low T, Ellenhorn JD and Kim J: The anatomic location of pancreatic cancer is a prognostic factor for survival. HPB (Oxford). 10:371–376. 2008. View Article : Google Scholar : PubMed/NCBI
15	Gunjan D, Rana S, Chhabra P, Parghane R, Kumar R, Dhalaria L, Mittal B and Bhasin D: Primary squamous cell carcinoma of pancreas mimicking walled-off pancreatic necrosis. J Dig Endosc. 7:17–19. 2016. View Article : Google Scholar
16	Ben Kridis W, Khanfir A, Toumi N, Ben Amar M, Boudawara T and Frikha M: Primary squamous cell carcinoma of the pancreas: A report of two cases and review of the literature. Intern Med. 54:1357–1359. 2015. View Article : Google Scholar
17	Terada T: Adenosquamous Carcinoma and Pure Squamous Cell Carcinoma of the Pancreas: Report of two Cases. Case Rep Gastroenterol. 4:369–373. 2010. View Article : Google Scholar : PubMed/NCBI
18	Tempero MA: Multidisciplinary management of pancreatic cancer. J Natl Compr Canc Netw. 13 Suppl 5:700–702. 2015. View Article : Google Scholar : PubMed/NCBI
19	Chakraborty S and Singh S: Surgical resection improves survival in pancreatic cancer patients without vascular invasion- a population based study. Ann Gastroenterol. 26:346–352. 2013.PubMed/NCBI
20	Hackert T, Sachsenmaier M, Hinz U, Schneider L, Michalski CW, Springfeld C, Strobel O, Jäger D, Ulrich A and Büchler MW: Locally advanced pancreatic cancer: Neoadjuvant therapy with folfirinox results in resectability in 60% of the patients. Ann Surg. 264:457–463. 2016. View Article : Google Scholar : PubMed/NCBI
21	Bideau K, Metges JP, Bayle S, André M, Robaszkiewicz M, Lagarde N and Labat JP: Treatment of squamous cell carcinoma of the pancreas with gemcitabine. Gastroenterol Clin Biol. 30:1217–1220. 2006.(In French). View Article : Google Scholar : PubMed/NCBI
22	De Souza AL and Saif MW: Squamous cell carcinoma of the pancreas. JOP. 15:630–631. 2014.PubMed/NCBI
23	Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, Seay T, Tjulandin SA, Ma WW, Saleh MN, et al: Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 369:1691–1703. 2013. View Article : Google Scholar
24	Von Hoff DD, Ramanathan RK, Borad MJ, Laheru DA, Smith LS, Wood TE, Korn RL, Desai N, Trieu V, Iglesias JL, et al: Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: A phase I/II trial. J Clin Oncol. 29:4548–4554. 2011. View Article : Google Scholar
25	Kataoka K, Matsubara H, Urano F, Okamura S and Maeda M: Nab-paclitaxel+gemcitabine therapy for adenosquamous carcinoma of the pancreas: An autopsy case. Nihon Shokakibyo Gakkai Zasshi. 113:1777–1784. 2016.(In Japanese). PubMed/NCBI
26	Brijbassie A, Stelow E and Shami VM: Squamous cell carcinoma of the pancreas: A case report and review of literature. Gastroenterol Res. 7:102–104. 2014.
27	Serafini F, Rosemurgy AS II and Carey LC: Squamous cell carcinoma of the pancreas. Am J Gastroenterol. 91:2621–2622. 1996.PubMed/NCBI
28	Brown HA, Dotto J, Robert M and Salem RR: Squamous cell carcinoma of the pancreas. J Clin Gastroenterol. 39:915–919. 2005. View Article : Google Scholar : PubMed/NCBI
29	Ntanasis-Stathopoulos I, Tsilimigras DI, Georgiadou D, Kanavidis P, Riccioni O, Salla C, Psaltopoulou T and Sergentanis TN: Squamous cell carcinoma of the pancreas: A systematic review and pooled survival analysis. Eur J Cancer. 79:193–204. 2017. View Article : Google Scholar : PubMed/NCBI
30	Ahmad A, Sheikh S, Ali SM, Paithankar M, Mehta A and Nagarkar R: Nanosomal paclitaxel lipid suspension demonstrates higher response rates compared to paclitaxel in patients with metastatic breast cancer. J Cancer Sci Ther. 07:116–120. 2015.
31	Gelderblom H, Verweij J, Nooter K and Sparreboom A: Cremophor EL: The drawbacks and advantages of vehicle selection for drug formulation. Eur J Cancer. 37:1590–1598. 2001. View Article : Google Scholar : PubMed/NCBI