Substantial improvement in immune thrombocytopenic purpura associated with T-cell/histiocyte-rich B-cell lymphoma treated with chemotherapy: A case report

Ogata,Takatsugu; Shimomura,Yoshimitsu; Yamashita,Daisuke; Imai,Yukihiro; Ishikawa,Takayuki

doi:10.3892/mco.2019.1816

April-2019 Volume 10 Issue 4

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April-2019 Volume 10 Issue 4

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Case Report

Substantial improvement in immune thrombocytopenic purpura associated with T-cell/histiocyte-rich B-cell lymphoma treated with chemotherapy: A case report

Authors:
- Takatsugu Ogata
- Yoshimitsu Shimomura
- Daisuke Yamashita
- Yukihiro Imai
- Takayuki Ishikawa
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Affiliations: Department of Medical Oncology, Kobe City Medical Center General Hospital, Kobe City Hospital Organization, Kobe, Hyogo 650-0047, Japan, Department of Hematology, Kobe City Medical Center General Hospital, Kobe City Hospital Organization, Kobe, Hyogo 650-0047, Japan, Department of Pathology, Kobe City Medical Center General Hospital, Kobe City Hospital Organization, Kobe, Hyogo 650-0047, Japan
Pages: 441-445
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Published online on: February 27, 2019

https://doi.org/10.3892/mco.2019.1816
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Abstract

Immune thrombocytopenic purpura (ITP) is characterized by antibody and immune platelet destruction, occasionally leading to life-threatening hemorrhage. ITP is a frequent complication of chronic lymphoid leukemia, but is rarely associated with diffuse large B-cell lymphoma (DLBCL). We herein describe a case of ITP associated with T-cell/histiocyte-rich B-cell lymphoma (T/HRBCL), which is a rare variant of DLBCL. A 54-year-old man presented with fever, multiple lymphadenopathies, petechial purpura and intraoral mucosal hemorrhage. Laboratory data revealed thrombocytopenia, normal white blood cell count, mild anemia, no active viral infections, and no autoimmune antibodies. Multiple lymphadenopathies were observed on computed tomography. A bone marrow biopsy revealed minor hypercellularity with increased number of megakaryocytes; however, there were no pathological cells or phagocytic cells. The patient was diagnosed with ITP; concurrently, he was also diagnosed with T/HRBCL via lymph node biopsy, and was treated accordingly with a chemotherapeutic regimen comprising rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone. Prompt reduction in the size of the superficial lymph nodes and an increase of the platelet count were observed simultaneously. To the best of our knowledge, this is the first report of T/HRBCL complicated by ITP. The findings strongly suggest a causative association between ITP and T/HRBCL.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Substantial improvement in immune thrombocytopenic purpura associated with T-cell/histiocyte-rich B-cell lymphoma treated with chemotherapy: A case report

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