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Case Report

Meningeal carcinomatosis from bladder cancer: A case report and review of the literature

  • Authors:
    • Yuta Umezawa
    • Suguru Shirotake
    • Go Kaneko
    • Koshiro Nishimoto
    • Yoshitaka Okada
    • Akira Uchino
    • Masanori Yasuda
    • Masafumi Oyama
  • View Affiliations / Copyright

    Affiliations: Department of Uro-Oncology, Saitama Medical University International Medical Center, Hidaka, Saitama 350-1298, Japan, Department of Diagnostic Radiology, Saitama Medical University International Medical Center, Hidaka, Saitama 350-1298, Japan, Department of Diagnostic Pathology, Saitama Medical University International Medical Center, Hidaka, Saitama 350-1298, Japan
  • Pages: 506-510
    |
    Published online on: March 5, 2019
       https://doi.org/10.3892/mco.2019.1820
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Abstract

A 66‑year‑old Japanese male patient was referred to Saitama Medical University International Medical Center for treatment of bladder cancer (clinical stage T2 or higher without metastasis), and underwent radical cystectomy with pelvic lymphadenectomy. The histopathological diagnosis was high‑grade urothelial carcinoma (pathological stage T2bN2, ly1, v0) and 2 cycles of adjuvant systemic chemotherapy (gemcitabine plus cisplatin) were administered. At 15 months after the operation, mediastinal and lung hilar lymph nodes and multiple bone metastases were identified on computed tomography imaging. After 3 cycles of the previous regimen as salvage systemic chemotherapy, the lymph node metastases had shrunk and the bone metastases were stable; therefore, further chemotherapy was planned. At 26 days after the initiation of the 4th cycle, the patient felt nausea and lower limb weakness. Spinal and brain magnetic resonance imaging with contrast medium revealed diffuse enhancement at the surface of the spinal cord and brain. In addition, abnormal signal intensity in the subarachnoid space was observed on fluid‑attenuated inversion recovery imaging; therefore, the patient was diagnosed with meningeal carcinomatosis (MC). Treatment, including whole‑brain radiotherapy, was planned for MC; however, the patient's condition rapidly worsened and he succumbed to the disease 14 days after the diagnosis of MC. The definitive diagnosis of MC was confirmed at autopsy.
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Copy and paste a formatted citation
Spandidos Publications style
Umezawa Y, Shirotake S, Kaneko G, Nishimoto K, Okada Y, Uchino A, Yasuda M and Oyama M: Meningeal carcinomatosis from bladder cancer: A case report and review of the literature. Mol Clin Oncol 10: 506-510, 2019.
APA
Umezawa, Y., Shirotake, S., Kaneko, G., Nishimoto, K., Okada, Y., Uchino, A. ... Oyama, M. (2019). Meningeal carcinomatosis from bladder cancer: A case report and review of the literature. Molecular and Clinical Oncology, 10, 506-510. https://doi.org/10.3892/mco.2019.1820
MLA
Umezawa, Y., Shirotake, S., Kaneko, G., Nishimoto, K., Okada, Y., Uchino, A., Yasuda, M., Oyama, M."Meningeal carcinomatosis from bladder cancer: A case report and review of the literature". Molecular and Clinical Oncology 10.5 (2019): 506-510.
Chicago
Umezawa, Y., Shirotake, S., Kaneko, G., Nishimoto, K., Okada, Y., Uchino, A., Yasuda, M., Oyama, M."Meningeal carcinomatosis from bladder cancer: A case report and review of the literature". Molecular and Clinical Oncology 10, no. 5 (2019): 506-510. https://doi.org/10.3892/mco.2019.1820
Copy and paste a formatted citation
x
Spandidos Publications style
Umezawa Y, Shirotake S, Kaneko G, Nishimoto K, Okada Y, Uchino A, Yasuda M and Oyama M: Meningeal carcinomatosis from bladder cancer: A case report and review of the literature. Mol Clin Oncol 10: 506-510, 2019.
APA
Umezawa, Y., Shirotake, S., Kaneko, G., Nishimoto, K., Okada, Y., Uchino, A. ... Oyama, M. (2019). Meningeal carcinomatosis from bladder cancer: A case report and review of the literature. Molecular and Clinical Oncology, 10, 506-510. https://doi.org/10.3892/mco.2019.1820
MLA
Umezawa, Y., Shirotake, S., Kaneko, G., Nishimoto, K., Okada, Y., Uchino, A., Yasuda, M., Oyama, M."Meningeal carcinomatosis from bladder cancer: A case report and review of the literature". Molecular and Clinical Oncology 10.5 (2019): 506-510.
Chicago
Umezawa, Y., Shirotake, S., Kaneko, G., Nishimoto, K., Okada, Y., Uchino, A., Yasuda, M., Oyama, M."Meningeal carcinomatosis from bladder cancer: A case report and review of the literature". Molecular and Clinical Oncology 10, no. 5 (2019): 506-510. https://doi.org/10.3892/mco.2019.1820
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