Paclitaxel for relapsed small‑cell lung cancer patients with idiopathic interstitial pneumonias

  • Authors:
    • Atsuro Saijo
    • Masaki Hanibuchi
    • Hirokazu Ogino
    • Kenji Otsuka
    • Hisatsugu Goto
    • Hiroshi Nokihara
    • Yasuhiko Nishioka
  • View Affiliations

  • Published online on: March 19, 2019     https://doi.org/10.3892/mco.2019.1828
  • Pages: 541-546
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Abstract

Although first‑line chemotherapy is highly sensitive against small‑cell lung cancer (SCLC), most patients subsequently experience disease progression. Topotecan is the standard therapy for sensitive‑relapsed SCLC patients, and subgroup analysis of a randomized phase III trial suggests that amrubicin is effective for refractory‑relapsed SCLC. However, because of the lack of the evidence based on clinical trials, the effectiveness of systemic chemotherapy for relapsed SCLC patients with idiopathic interstitial pneumonias (IIPs) is unclear. In the presentstudy, 17 relapsed SCLC patients with IIPs who received a paclitaxel (PTX)‑containing regimen as a second‑line chemotherapy were retrospectively reviewed. The overall response rate and the disease control rate of the PTX‑containing regimens were 29.4 and 47.1%, respectively. The median progression‑free survival and the overall survival of the regimens were 2.7 months [95% confidence interval (CI), 1.6‑3.6 months] and 3.6 months (95% CI, 2.3‑14.0 months), respectively. Grade 3‑4 neutropenia and febrile neutropenia occurred in 12 (70.6%) and 2 (11.8%) patients, respectively. During the treatment period, acute exacerbation (AE) of IIPs was observed in five patients (29.4%). Treatment‑associated fatality was observed in 1 patient with febrile neutropenia and in 1 patient with AE of IIPs. PTX had promising anti‑tumor activity against refractory‑relapsed SCLC with IIPs. However, the survival benefit of the treatment was limited because of the high incidence of AE of IIPs and treatment‑related death.
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May-2019
Volume 10 Issue 5

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Spandidos Publications style
Saijo A, Hanibuchi M, Ogino H, Otsuka K, Goto H, Nokihara H and Nishioka Y: Paclitaxel for relapsed small‑cell lung cancer patients with idiopathic interstitial pneumonias. Mol Clin Oncol 10: 541-546, 2019
APA
Saijo, A., Hanibuchi, M., Ogino, H., Otsuka, K., Goto, H., Nokihara, H., & Nishioka, Y. (2019). Paclitaxel for relapsed small‑cell lung cancer patients with idiopathic interstitial pneumonias. Molecular and Clinical Oncology, 10, 541-546. https://doi.org/10.3892/mco.2019.1828
MLA
Saijo, A., Hanibuchi, M., Ogino, H., Otsuka, K., Goto, H., Nokihara, H., Nishioka, Y."Paclitaxel for relapsed small‑cell lung cancer patients with idiopathic interstitial pneumonias". Molecular and Clinical Oncology 10.5 (2019): 541-546.
Chicago
Saijo, A., Hanibuchi, M., Ogino, H., Otsuka, K., Goto, H., Nokihara, H., Nishioka, Y."Paclitaxel for relapsed small‑cell lung cancer patients with idiopathic interstitial pneumonias". Molecular and Clinical Oncology 10, no. 5 (2019): 541-546. https://doi.org/10.3892/mco.2019.1828