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Article

Comparison between stereotactic radiosurgery and whole‑brain radiotherapy for 10‑20 brain metastases from non‑small cell lung cancer

  • Authors:
    • Takaaki Mizuno
    • Kazuto Takada
    • Toshinori Hasegawa
    • Tatsuya Yoshida
    • Kenta Murotani
    • Hironori Kobayashi
    • Tsutomu Sakurai
    • Yuuki Yamashita
    • Nana Akazawa
    • Eiji Kojima
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Komaki City Hospital, Gamma Knife Center, Komaki, Aichi 485‑8520, Japan, Department of Neurosurgery, Komaki City Hospital, Gamma Knife Center, Komaki, Aichi 485‑8520, Japan, Department of Thoracic Oncology, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑0021, Japan, Division of Biostatistics, Clinical Research Center, Aichi Medical University Hospital, Nagakute, Aichi 480‑1103, Japan
  • Pages: 560-566
    |
    Published online on: March 20, 2019
       https://doi.org/10.3892/mco.2019.1830
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Abstract

The efficacy and safety of stereotactic radiosurgery (SRS) in comparison with whole brain radiotherapy (WBRT) for brain metastases (BMs) remains unclear. The present study retrospectively reviewed 44 patients who received SRS or WBRT as an initial treatment for 10‑20 BMs from non‑small cell lung cancer between 2009 and 2016. Of the patients, 24 (54.5%) were treated with SRS and 20 (45.5%) were treated with WBRT. Overall survival (OS), time to intracranial progression (TTIP), neurological survival (NS), and prognostic factors were examined. OS did not significantly differ between the two groups: 7.3 months in the SRS group vs. 7.2 months in the WBRT group (P=0.502). Median TTIP was significantly shorter in the SRS group than in the WBRT group (7.1 vs. 19.1 months, P=0.009). In contrast, there were no significant differences in NS between the two groups (14.5 months in the SRS group vs. 12.9 months in the WBRT group, P=0.346). Univariate and multivariate analysis revealed that the type of initial treatment for BMs (WBRT or SRS) was not a significant prognostic factor (hazard ratio=0.80, 95% confidence interval: 0.42‑1.52, P=0.502). However, histology, performance status, subsequent molecular targeted drugs, subsequent chemotherapy and salvage treatment were independent prognostic factors. There were no significant differences in OS and NS between treatment with SRS and treatment with WBRT in patients with 10‑20 BMs, although TTIP was improved with WBRT. As an upfront treatment for 10‑20 BMs, SRS may delay WBRT and the adverse events associated with WBRT.
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Copy and paste a formatted citation
Spandidos Publications style
Mizuno T, Takada K, Hasegawa T, Yoshida T, Murotani K, Kobayashi H, Sakurai T, Yamashita Y, Akazawa N, Kojima E, Kojima E, et al: Comparison between stereotactic radiosurgery and whole‑brain radiotherapy for 10‑20 brain metastases from non‑small cell lung cancer. Mol Clin Oncol 10: 560-566, 2019.
APA
Mizuno, T., Takada, K., Hasegawa, T., Yoshida, T., Murotani, K., Kobayashi, H. ... Kojima, E. (2019). Comparison between stereotactic radiosurgery and whole‑brain radiotherapy for 10‑20 brain metastases from non‑small cell lung cancer. Molecular and Clinical Oncology, 10, 560-566. https://doi.org/10.3892/mco.2019.1830
MLA
Mizuno, T., Takada, K., Hasegawa, T., Yoshida, T., Murotani, K., Kobayashi, H., Sakurai, T., Yamashita, Y., Akazawa, N., Kojima, E."Comparison between stereotactic radiosurgery and whole‑brain radiotherapy for 10‑20 brain metastases from non‑small cell lung cancer". Molecular and Clinical Oncology 10.5 (2019): 560-566.
Chicago
Mizuno, T., Takada, K., Hasegawa, T., Yoshida, T., Murotani, K., Kobayashi, H., Sakurai, T., Yamashita, Y., Akazawa, N., Kojima, E."Comparison between stereotactic radiosurgery and whole‑brain radiotherapy for 10‑20 brain metastases from non‑small cell lung cancer". Molecular and Clinical Oncology 10, no. 5 (2019): 560-566. https://doi.org/10.3892/mco.2019.1830
Copy and paste a formatted citation
x
Spandidos Publications style
Mizuno T, Takada K, Hasegawa T, Yoshida T, Murotani K, Kobayashi H, Sakurai T, Yamashita Y, Akazawa N, Kojima E, Kojima E, et al: Comparison between stereotactic radiosurgery and whole‑brain radiotherapy for 10‑20 brain metastases from non‑small cell lung cancer. Mol Clin Oncol 10: 560-566, 2019.
APA
Mizuno, T., Takada, K., Hasegawa, T., Yoshida, T., Murotani, K., Kobayashi, H. ... Kojima, E. (2019). Comparison between stereotactic radiosurgery and whole‑brain radiotherapy for 10‑20 brain metastases from non‑small cell lung cancer. Molecular and Clinical Oncology, 10, 560-566. https://doi.org/10.3892/mco.2019.1830
MLA
Mizuno, T., Takada, K., Hasegawa, T., Yoshida, T., Murotani, K., Kobayashi, H., Sakurai, T., Yamashita, Y., Akazawa, N., Kojima, E."Comparison between stereotactic radiosurgery and whole‑brain radiotherapy for 10‑20 brain metastases from non‑small cell lung cancer". Molecular and Clinical Oncology 10.5 (2019): 560-566.
Chicago
Mizuno, T., Takada, K., Hasegawa, T., Yoshida, T., Murotani, K., Kobayashi, H., Sakurai, T., Yamashita, Y., Akazawa, N., Kojima, E."Comparison between stereotactic radiosurgery and whole‑brain radiotherapy for 10‑20 brain metastases from non‑small cell lung cancer". Molecular and Clinical Oncology 10, no. 5 (2019): 560-566. https://doi.org/10.3892/mco.2019.1830
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