Malignant rhabdoid tumour in an adult kidney: A case report

Okumura,Yoshinaga; Adachi,Yasushi; Shirahase,Toshihiro; Nagashima,Yoji; Tanaka,Yukichi; Taki,Yoji; Watanabe,Jun; Uegaki,Masayuki; Sakatani,Toru; Ikehara,Susumu

doi:10.3892/mco.2019.1848

July-2019 Volume 11 Issue 1

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July-2019 Volume 11 Issue 1

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Case Report

Malignant rhabdoid tumour in an adult kidney: A case report

Authors:
- Yoshinaga Okumura
- Yasushi Adachi
- Toshihiro Shirahase
- Yoji Nagashima
- Yukichi Tanaka
- Yoji Taki
- Jun Watanabe
- Masayuki Uegaki
- Toru Sakatani
- Susumu Ikehara
View Affiliations / Copyright

Affiliations: Department of Urology, Toyooka Hospital, Toyooka, Hyogo 668‑8501, Japan, Department of Diagnostic Pathology, Toyooka Hospital, Toyooka, Hyogo 668‑8501, Japan, Department of Surgical Pathology, Tokyo Women's Medical University, Tokyo 162‑8666, Japan, Clinical Research Institute and Department of Pathology, Kanagawa Children's Medical Center, Yokohama, Kanagawa 232‑8555, Japan, Professor Emeritus, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan
Pages: 55-58
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Published online on: April 24, 2019

https://doi.org/10.3892/mco.2019.1848
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Abstract

Malignant rhabdoid tumours (MRTs) in the kidney are rare paediatric tumours that are extremely rare in adults. We herein report the case of an adult patient with a renal MRT. A 79‑year‑old Japanese woman was found to have a tumour sized 63x48 mm in the left kidney, in addition to multiple metastatic bone and lymph node lesions. The needle biopsy specimen obtained from the patient's kidney revealed tumour cells with rhabdoid characteristics: The cells appeared large, round or polygonal, with eccentrically located nuclei and prominent nucleoli. Immunohistochemically, the tumour cells were positive for vimentin, epithelial membrane antigen, CAM 5.2, and p53, and negative for INI1, cytokeratin (CK)7, CK20, α‑methylacyl‑CoA racemase, S100, CD45, renal cell carcinoma marker, anaplastic lymphoma kinase, α‑smooth muscle actin, desmin, MyoD, myogenin, human melanoma black 45 and melan A. Therefore, the tumour was diagnosed as an MRT located in the kidney. Although the patient was treated with axitinib, a tyrosine kinase inhibitor, the renal tumour and its metastatic lesions continued to progress, and the number of metastatic lesions increased. The patient succumbed to the disease 5 months after the first hospital visit. The disease progression was rapid, with a poor prognosis, consistently with previous reports that of MRTs in the adult kidney.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Malignant rhabdoid tumour in an adult kidney: A case report

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