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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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July-2019 Volume 11 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Case Report

Neurokinin‑1 receptor antagonist aprepitant and radiotherapy, a successful combination therapy in a patient with lung cancer: A case report

  • Authors:
    • Miguel Muñoz
    • Juan Carlos Crespo
    • José Pedro Crespo
    • Rafael Coveñas
  • View Affiliations / Copyright

    Affiliations: Research Laboratory on Neuropeptides (IBIS), Virgen del Rocío University Hospital, 41013 Sevilla, Spain, Department of Pharmacology, Pediatric and Radiology, University of Sevilla, 41009 Sevilla, Spain, SEVISTON Laboratory Pathology, 41001 Sevilla, Spain, Institute of Neurosciences of Castilla y León (INCYL), Laboratory of Neuroanatomy of the Peptidergic Systems (Lab. 14), University of Salamanca, 37007 Salamanca, Spain
  • Pages: 50-54
    |
    Published online on: May 10, 2019
       https://doi.org/10.3892/mco.2019.1857
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Abstract

Lung cancer (LC) is the leading cause of cancer death and is responsible for more than one‑quarter (27%) of all cancer deaths. Non‑small‑cell LC (NSCLC) is the main histological subtype of LC and is the leading cause of mortalities associated with cancer. This case report focused on a patient showing a history of chronic obstructive pulmonary disease (COPD) with a NSCLC squamous cell carcinoma (single mass with a diameter of 8x7 cm, without metastasis). Due to the COPD, neither a surgical treatment (pneumonectomy) nor chemotherapy was possible. After 15 days following the diagnosis, the patient was treated for 45 days with radiotherapy and the neurokinin‑1 receptor, aprepitant (compassionate use, 1,140 mg/day). Radiotherapy was administered to the right lung and mediastinum, reaching 50.4 Gy and then overprinted to 65 Gy. In each successive control, the tumor volume decreased and, after 6 months of treatment, the chest computed tomography scan showed that the tumor mass had disappeared. No side‑effects were observed during the combination therapy; in contrast, the patient was in very good general health with a weight gain and showing no biochemical analytical alteration. This case report suggests a witness episode to the antitumor effect of aprepitant/radiotherapy against NSCLC. Urgent development is required for clinical trials to test the combination treatment (radiotherapy and aprepitant) as an antitumor therapy for patients with LC.
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Copy and paste a formatted citation
Spandidos Publications style
Muñoz M, Crespo JC, Crespo JP and Coveñas R: Neurokinin‑1 receptor antagonist aprepitant and radiotherapy, a successful combination therapy in a patient with lung cancer: A case report. Mol Clin Oncol 11: 50-54, 2019.
APA
Muñoz, M., Crespo, J.C., Crespo, J.P., & Coveñas, R. (2019). Neurokinin‑1 receptor antagonist aprepitant and radiotherapy, a successful combination therapy in a patient with lung cancer: A case report. Molecular and Clinical Oncology, 11, 50-54. https://doi.org/10.3892/mco.2019.1857
MLA
Muñoz, M., Crespo, J. C., Crespo, J. P., Coveñas, R."Neurokinin‑1 receptor antagonist aprepitant and radiotherapy, a successful combination therapy in a patient with lung cancer: A case report". Molecular and Clinical Oncology 11.1 (2019): 50-54.
Chicago
Muñoz, M., Crespo, J. C., Crespo, J. P., Coveñas, R."Neurokinin‑1 receptor antagonist aprepitant and radiotherapy, a successful combination therapy in a patient with lung cancer: A case report". Molecular and Clinical Oncology 11, no. 1 (2019): 50-54. https://doi.org/10.3892/mco.2019.1857
Copy and paste a formatted citation
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Spandidos Publications style
Muñoz M, Crespo JC, Crespo JP and Coveñas R: Neurokinin‑1 receptor antagonist aprepitant and radiotherapy, a successful combination therapy in a patient with lung cancer: A case report. Mol Clin Oncol 11: 50-54, 2019.
APA
Muñoz, M., Crespo, J.C., Crespo, J.P., & Coveñas, R. (2019). Neurokinin‑1 receptor antagonist aprepitant and radiotherapy, a successful combination therapy in a patient with lung cancer: A case report. Molecular and Clinical Oncology, 11, 50-54. https://doi.org/10.3892/mco.2019.1857
MLA
Muñoz, M., Crespo, J. C., Crespo, J. P., Coveñas, R."Neurokinin‑1 receptor antagonist aprepitant and radiotherapy, a successful combination therapy in a patient with lung cancer: A case report". Molecular and Clinical Oncology 11.1 (2019): 50-54.
Chicago
Muñoz, M., Crespo, J. C., Crespo, J. P., Coveñas, R."Neurokinin‑1 receptor antagonist aprepitant and radiotherapy, a successful combination therapy in a patient with lung cancer: A case report". Molecular and Clinical Oncology 11, no. 1 (2019): 50-54. https://doi.org/10.3892/mco.2019.1857
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