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Article

Favorable outcomes of localized synovial sarcoma patients with a high utilization rate of neoadjuvant and/or adjuvant chemotherapy

  • Authors:
    • Hidetatsu Outani
    • Shigeki Kakunaga
    • Kenichiro Hamada
    • Satoshi Takenaka
    • Yoshinori Imura
    • Shigenori Nagata
    • Takaaki Tanaka
    • Hironari Tamiya
    • Kazuya Oshima
    • Norifumi Naka
    • Ikuo Kudawara
    • Nobuhito Araki
    • Takafumi Ueda
    • Hideki Yoshikawa
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan, Department of Orthopaedic Surgery, Osaka National Hospital, Chuo‑ku, Osaka 540‑0006, Japan, Musculoskeletal Oncology Service, Osaka International Cancer Institute, Chuo‑ku, Osaka 541‑8567, Japan, Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute, Chuo‑ku, Osaka 541‑8567, Japan, Department of Orthopaedic Surgery, Bell‑land General Hospital, Sakai, Osaka 599‑8247, Japan, Department of Orthopaedic Surgery, Ashiya Municipal Hospital, Ashiya, Hyogo 659‑8502, Japan
  • Pages: 151-156
    |
    Published online on: May 21, 2019
       https://doi.org/10.3892/mco.2019.1863
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Abstract

Synovial sarcoma (SS) is considered to be a chemosensitive, soft tissue sarcoma. Therefore, neoadjuvant and/or adjuvant chemotherapy (N/AC) is used for the treatment of high‑risk SS patients. However, the role of N/AC remains controversial. The present study aimed to review the clinical outcomes of surgically treated localized SS and investigate the effects of N/AC with long‑term observation. The clinical outcomes of 54 patients with surgically treated localized SS were retrospectively analyzed. The median patient age was 42 years (range, 8‑81 years), and the median follow‑up period was 94 months for survivors (range, 7‑220 months). A total of 38 patients (70%) received chemotherapy. Of these, 32 (59%) patients received neoadjuvant chemotherapy, 33 (61%) received adjuvant chemotherapy, and 27 (50%) received neoadjuvant and adjuvant chemotherapy. Fourteen patients (26%) received adjuvant radiotherapy. Three patients (6%) had local recurrence and 13 patients (24%) developed distant metastasis. The overall survival (OS) rates at 5 and 10 years were 87 and 84%, respectively. N/AC did not improve survival. In conclusion, we found satisfactory long‑term OS among patients with a high utilization rate of N/AC. Further study should be necessary to evaluate which population of SS would benefit from N/AC.
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Copy and paste a formatted citation
Spandidos Publications style
Outani H, Kakunaga S, Hamada K, Takenaka S, Imura Y, Nagata S, Tanaka T, Tamiya H, Oshima K, Naka N, Naka N, et al: Favorable outcomes of localized synovial sarcoma patients with a high utilization rate of neoadjuvant and/or adjuvant chemotherapy. Mol Clin Oncol 11: 151-156, 2019.
APA
Outani, H., Kakunaga, S., Hamada, K., Takenaka, S., Imura, Y., Nagata, S. ... Yoshikawa, H. (2019). Favorable outcomes of localized synovial sarcoma patients with a high utilization rate of neoadjuvant and/or adjuvant chemotherapy. Molecular and Clinical Oncology, 11, 151-156. https://doi.org/10.3892/mco.2019.1863
MLA
Outani, H., Kakunaga, S., Hamada, K., Takenaka, S., Imura, Y., Nagata, S., Tanaka, T., Tamiya, H., Oshima, K., Naka, N., Kudawara, I., Araki, N., Ueda, T., Yoshikawa, H."Favorable outcomes of localized synovial sarcoma patients with a high utilization rate of neoadjuvant and/or adjuvant chemotherapy". Molecular and Clinical Oncology 11.2 (2019): 151-156.
Chicago
Outani, H., Kakunaga, S., Hamada, K., Takenaka, S., Imura, Y., Nagata, S., Tanaka, T., Tamiya, H., Oshima, K., Naka, N., Kudawara, I., Araki, N., Ueda, T., Yoshikawa, H."Favorable outcomes of localized synovial sarcoma patients with a high utilization rate of neoadjuvant and/or adjuvant chemotherapy". Molecular and Clinical Oncology 11, no. 2 (2019): 151-156. https://doi.org/10.3892/mco.2019.1863
Copy and paste a formatted citation
x
Spandidos Publications style
Outani H, Kakunaga S, Hamada K, Takenaka S, Imura Y, Nagata S, Tanaka T, Tamiya H, Oshima K, Naka N, Naka N, et al: Favorable outcomes of localized synovial sarcoma patients with a high utilization rate of neoadjuvant and/or adjuvant chemotherapy. Mol Clin Oncol 11: 151-156, 2019.
APA
Outani, H., Kakunaga, S., Hamada, K., Takenaka, S., Imura, Y., Nagata, S. ... Yoshikawa, H. (2019). Favorable outcomes of localized synovial sarcoma patients with a high utilization rate of neoadjuvant and/or adjuvant chemotherapy. Molecular and Clinical Oncology, 11, 151-156. https://doi.org/10.3892/mco.2019.1863
MLA
Outani, H., Kakunaga, S., Hamada, K., Takenaka, S., Imura, Y., Nagata, S., Tanaka, T., Tamiya, H., Oshima, K., Naka, N., Kudawara, I., Araki, N., Ueda, T., Yoshikawa, H."Favorable outcomes of localized synovial sarcoma patients with a high utilization rate of neoadjuvant and/or adjuvant chemotherapy". Molecular and Clinical Oncology 11.2 (2019): 151-156.
Chicago
Outani, H., Kakunaga, S., Hamada, K., Takenaka, S., Imura, Y., Nagata, S., Tanaka, T., Tamiya, H., Oshima, K., Naka, N., Kudawara, I., Araki, N., Ueda, T., Yoshikawa, H."Favorable outcomes of localized synovial sarcoma patients with a high utilization rate of neoadjuvant and/or adjuvant chemotherapy". Molecular and Clinical Oncology 11, no. 2 (2019): 151-156. https://doi.org/10.3892/mco.2019.1863
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