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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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August-2019 Volume 11 Issue 2

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Case Report

Adjuvant recombinant thrombomodulin therapy for hepatopathy induced by vincristine, actinomycin D, and cyclophosphamide in pediatric rhabdomyosarcoma: A case report

  • Authors:
    • Tetsuko Kobayashi
    • Maiko Noguchi
    • Hideki Nakayama
    • Reiji Fukano
    • Shouichi Ohga
  • View Affiliations / Copyright

    Affiliations: Division of Pediatrics, National Hospital Organization Kyushu Cancer Center, Fukuoka 811‑1395, Japan, Department of Pediatrics, Kyushu University Hospital, Fukuoka 812‑8582, Japan
  • Pages: 208-212
    |
    Published online on: May 22, 2019
       https://doi.org/10.3892/mco.2019.1864
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Abstract

Hepatopathy induced by vincristine, actinomycin D and cyclophosphamide (VAC) is a potentially lethal complication of VAC chemotherapy for pediatric malignancy, which is managed by conventional anticoagulation and liver‑supporting treatment alone. We report a case of VAC‑induced hepatopathy with coagulopathy and severe inflammation. A 15‑year‑old male with rhabdomyosarcoma receiving adjuvant chemotherapy presented with refractory thrombocytopenia, followed by abdominal tenderness and non‑neutropenic fever. Hepatic dysfunction and coagulopathy subsequently emerged with persistent fever. This condition indicated disseminated intravascular coagulation. A diagnosis of ‘very severe’ sinusoidal obstruction syndrome/veno‑occlusive disease (SOS/VOD) was established in accordance with the European Society for Blood and Marrow Transplantation diagnostic criteria for hepatic SOS/VOD in children. Early administration of recombinant thrombomodulin (rTM) (380 U/kg/day) and prednisolone (1.8 mg/kg/day) successfully controlled the condition. Serum concentrations of pro‑inflammatory cytokines increased with hepatopathy development but immediately decreased after drug initiation. rTM administration may be promising for the control of inflammatory VAC‑induced hepatopathy.
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1 

Corbacioglu S, Carreras E, Ansari M, Balduzzi A, Cesaro S, Dalle JH, Dignan F, Gibson B, Guengoer T, Gruhn B, et al: Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: A new classification from the European society for blood and marrow transplantation. Bone Marrow Transplant. 53:138–145. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Ortega JA, Donaldson SS, Ivy SP, Pappo A and Maurer HM: Venoocclusive disease of the liver after chemotherapy with vincristine, actinomycin D, and cyclophosphamide for the treatment of rhabdomyosarcoma. A report of the intergroup rhabdomyosarcoma study group. Childrens cancer group, the pediatric oncoloy group, and the pediatric intergroup statistical center. Cancer. 79:2435–2439. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Sulis ML, Bessmertny O, Granowetter L, Weiner M and Kelly KM: Veno-occlusive disease in pediatric patients receiving actinomycin D and vincristine only for the treatment of rhabdomyosarcoma. J Pediatr Hematol Oncol. 26:843–846. 2004.PubMed/NCBI

4 

Arndt C, Hawkins D, Anderson JR, Breitfeld P, Womer R and Meyer W: Age is a risk factor for chemotherapy-induced hepatopathy with vincristine, dactinomycin, and cyclophosphamide. J Clin Oncol. 22:1894–1901. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Saito H, Maruyama I, Shimazaki S, Yamamoto Y, Aikawa N, Ohno R, Hirayama A, Matsuda T, Asakura H, Nakashima M and Aoki N: Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: Results of a phase III, randomized, double-blind clinical trial. J Thromb Haemost. 5:31–41. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Abeyama K, Stern DM, Ito Y, Kawahara K, Yoshimoto Y, Tanaka M, Uchimura T, Ida N, Yamazaki Y, Yamada S, et al: The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel anti-inflammatory mechanism. J Clin Invest. 115:1267–1274. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Loghmani H and Conway EM: Exploring traditional and nontraditional roles for thrombomodulin. Blood. 132:148–158. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Walterhouse DO, Pappo AS, Meza JL, Breneman JC, Hayes-Jordan AA, Parham DM, Cripe TP, Anderson JR, Meyer WH and Hawkins DS: Shorter-duration therapy using vincristine, dactinomycin, and lower-dose cyclophosphamide with or without radiotherapy for patients with newly diagnosed low-risk rhabdomyosarcoma: A report from the soft tissue sarcoma committee of the children's oncology group. J Clin Oncol. 32:3547–3552. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Wada H, Takahashi H, Uchiyama T, Eguchi Y, Okamoto K, Kawasugi K, Madoiwa S and Asakura H; Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis, : The approval of revised diagnostic criteria for DIC from the Japanese Society on thrombosis and hemostasis. Thromb J. 15:172017. View Article : Google Scholar : PubMed/NCBI

10 

Henter JI, Horne A, Aricó M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J and Janka G: HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 48:124–131. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Allen CE, Yu X, Kozinetz CA and McClain KL: Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 50:1227–1235. 2008. View Article : Google Scholar : PubMed/NCBI

12 

DeLeve LD, Shulman HM and McDonald GB: Toxic injury to hepatic sinusoids: Sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis. 22:27–42. 2002. View Article : Google Scholar : PubMed/NCBI

13 

DeLeve LD, Ito Y, Bethea NW, McCuskey MK, Wang X and McCuskey RS: Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome. Am J Physiol Gastrointest Liver Physiol. 284:G1045–G1052. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Szabo G and Petrasek J: Inflammasome activation and function in liver disease. Nat Rev Gastroenterol Hepatol. 12:387–400. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Schmidt-Arras D and Rose-John S: IL-6 pathway in the liver: From physiopathology to therapy. J Hepatol. 64:1403–1415. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Sato K, Hall C, Glaser S, Francis H, Meng F and Alpini G: Pathogenesis of kupffer cells in cholestatic liver injury. Am J Pathol. 186:2238–2247. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Kanwar VS, Albuquerque ML, Ribeiro RC, Kauffman WM and Furman WL: Veno-occlusive disease of the liver after chemotherapy for rhabdomyosarcoma: Case report with a review of the literature. Med Pediatr Oncol. 24:334–340. 1995. View Article : Google Scholar : PubMed/NCBI

18 

Adachi N and Matsuda I: Veno-occlusive disease of the liver after combined adjuvant chemotherapy for a 1-year-old boy with rhabdomyosarcoma: Potential usefulness of the gabexate mesylate (FOY). J Pediatr Gastroenterol Nutr. 14:314–318. 1992. View Article : Google Scholar : PubMed/NCBI

19 

D'Antiga L, Baker A, Pritchard J, Pryor D and Mieli-Vergani G: Veno-occlusive disease with multi-organ involvement following actinomycin-D. Eur J Cancer. 37:1141–1148. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Cecen E, Uysal KM, Ozguven A, Gunes D, Irken G and Olgun N: Veno-occlusive disease in a child with rhabdomyosarcoma after conventional chemotherapy: Report of a case and review of the literature. Pediatr Hematol Oncol. 24:615–621. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Chen IL, Yang SN, Hsiao CC, Wu KS and Sheen JM: Treatment with high-dose methylprednisolone for hepatic veno-occlusive disease in a child with rhabdomyosarcoma. Pediatr Neonatol. 49:141–144. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Choi A, Kang YK, Lim S, Kim DH, Lim JS and Lee JA: Severe hepatic sinusoidal obstruction syndrome in a child receiving vincristine, actinomycin-D, and cyclophosphamide for rhabdomyosarcoma: Successful treatment with defibrotide. Cancer Res Treat. 48:1443–1447. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Kernan NA, Richardson PG, Smith AR, Triplett BM, Antin JH, Lehmann L, Messinger Y, Liang W, Hume R, Tappe W, et al: Defibrotide for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome following nontransplant-associated chemotherapy: Final results from a post hoc analysis of data from an expanded-access program. Pediatr Blood Cancer. 65:e272692018. View Article : Google Scholar : PubMed/NCBI

24 

Scaffidi P, Misteli T and Bianchi ME: Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature. 418:191–195. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Ulfgren AK, Grundtman C, Borg K, Alexanderson H, Andersson U, Harris HE and Lundberg IE: Down-regulation of the aberrant expression of the inflammation mediator high mobility group box chromosomal protein 1 in muscle tissue of patients with polymyositis and dermatomyositis treated with corticosteroids. Arthritis Rheum. 50:1586–1594. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Kurokohchi K, Imataki O and Kubo F: Anti-inflammatory effect of recombinant thrombomodulin for fulminant hepatic failure. World J Gastroenterol. 21:8203–8207. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Wei F, Liu S, Luo L, Gu N, Zeng Y, Chen X, Xu S and Zhang D: Anti-inflammatory mechanism of ulinastatin: Inhibiting the hyperpermeability of vascular endothelial cells induced by TNF-α via the RhoA/ROCK signal pathway. Int Immunopharmacol. 46:220–227. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kobayashi T, Noguchi M, Nakayama H, Fukano R and Ohga S: Adjuvant recombinant thrombomodulin therapy for hepatopathy induced by vincristine, actinomycin D, and cyclophosphamide in pediatric rhabdomyosarcoma: A case report. Mol Clin Oncol 11: 208-212, 2019.
APA
Kobayashi, T., Noguchi, M., Nakayama, H., Fukano, R., & Ohga, S. (2019). Adjuvant recombinant thrombomodulin therapy for hepatopathy induced by vincristine, actinomycin D, and cyclophosphamide in pediatric rhabdomyosarcoma: A case report. Molecular and Clinical Oncology, 11, 208-212. https://doi.org/10.3892/mco.2019.1864
MLA
Kobayashi, T., Noguchi, M., Nakayama, H., Fukano, R., Ohga, S."Adjuvant recombinant thrombomodulin therapy for hepatopathy induced by vincristine, actinomycin D, and cyclophosphamide in pediatric rhabdomyosarcoma: A case report". Molecular and Clinical Oncology 11.2 (2019): 208-212.
Chicago
Kobayashi, T., Noguchi, M., Nakayama, H., Fukano, R., Ohga, S."Adjuvant recombinant thrombomodulin therapy for hepatopathy induced by vincristine, actinomycin D, and cyclophosphamide in pediatric rhabdomyosarcoma: A case report". Molecular and Clinical Oncology 11, no. 2 (2019): 208-212. https://doi.org/10.3892/mco.2019.1864
Copy and paste a formatted citation
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Spandidos Publications style
Kobayashi T, Noguchi M, Nakayama H, Fukano R and Ohga S: Adjuvant recombinant thrombomodulin therapy for hepatopathy induced by vincristine, actinomycin D, and cyclophosphamide in pediatric rhabdomyosarcoma: A case report. Mol Clin Oncol 11: 208-212, 2019.
APA
Kobayashi, T., Noguchi, M., Nakayama, H., Fukano, R., & Ohga, S. (2019). Adjuvant recombinant thrombomodulin therapy for hepatopathy induced by vincristine, actinomycin D, and cyclophosphamide in pediatric rhabdomyosarcoma: A case report. Molecular and Clinical Oncology, 11, 208-212. https://doi.org/10.3892/mco.2019.1864
MLA
Kobayashi, T., Noguchi, M., Nakayama, H., Fukano, R., Ohga, S."Adjuvant recombinant thrombomodulin therapy for hepatopathy induced by vincristine, actinomycin D, and cyclophosphamide in pediatric rhabdomyosarcoma: A case report". Molecular and Clinical Oncology 11.2 (2019): 208-212.
Chicago
Kobayashi, T., Noguchi, M., Nakayama, H., Fukano, R., Ohga, S."Adjuvant recombinant thrombomodulin therapy for hepatopathy induced by vincristine, actinomycin D, and cyclophosphamide in pediatric rhabdomyosarcoma: A case report". Molecular and Clinical Oncology 11, no. 2 (2019): 208-212. https://doi.org/10.3892/mco.2019.1864
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