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Article

Roles of long non-coding RNAs in colorectal cancer tumorigenesis: A Review

  • Authors:
    • Halima Siddiqui
    • Ayat Al-Ghafari
    • Hani Choudhry
    • Huda Al Doghaither
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 23817, Kingdom of Saudi Arabia
  • Pages: 167-172
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    Published online on: May 31, 2019
       https://doi.org/10.3892/mco.2019.1872
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Abstract

Long non‑coding RNAs (lncRNAs) are newly identified potential biological and gene regulators. Similar to other cell‑free circulating cancer‑related nucleic acids, lncRNAs are released in the peripheral circulation of cancer patients and allow for non‑invasive gene expression assessment. lncRNAs are considered to be promising biomarkers for cancer prognosis and diagnosis. Several lncRNAs have been found to regulate developmental processes in a number of biological disorders. Recent studies indicated that lncRNAs are associated with numerous diseases, most notably cancer, as they were found to be highly expressed or silenced in a number of human cancers, including colorectal cancer (CRC). Despite advances in the current detection methods, over half of cancer patients succumb to the disease, as several CRC cases are diagnosed at an advanced stage. Due to the lack of non‑invasive and low‑cost prognostic and diagnostic tests for CRC, the identification of novel, potentially effective biomarkers has been attracting increasing attention in recent cancer research. The present review focused on the most widely applied lncRNAs in cancer detection, including CRC, in vitro.
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View References

1 

American Cancer Society: Colorectal Cancer Facts & Figures 2014-2016. American Cancer Society; Atlanta: pp. 1–32

2 

Kheirelseid EA, Miller N, Chang KH, Nugent M and Kerin MJ: Clinical applications of gene expression in colorectal cancer. J Gastrointest Oncol. 4:144–157. 2013.PubMed/NCBI

3 

Luo J, Qu J, Wu DK, Lu ZL, Sun YS and Qu Q: Long non-coding RNAs: A rising biotarget in colorectal cancer. Oncotarget. 8:22187–22202. 2017.PubMed/NCBI

4 

El Zoghbi M and Cummings LC: New era of colorectal cancer screening. World J Gastrointest Endosc. 8:252–258. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Chen T, Yang P, Wang H and He ZY: Silence of long noncoding RNA PANDAR switches low-dose curcumin-induced senescence to apoptosis in colorectal cancer cells. OncoTargets Ther. 10:483–491. 2017. View Article : Google Scholar

6 

Rinn JL and Chang HY: Genome regulation by long noncoding RNAs. Annu Rev Biochem. 81:145–166. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Okugawa Y, Grady WM and Goel A: Epigenetic alterations in colorectal cancer: Emerging biomarkers. Gastroenterology. 149:1204–1225.e12. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Dou J, Ni Y, He X, Wu D, Li M, Wu S, Zhang R, Guo M and Zhao F: Decreasing lncRNA HOTAIR expression inhibits human colorectal cancer stem cells. Am J Transl Res. 8:98–108. 2016.PubMed/NCBI

9 

Peng W and Fan H: Long non-coding RNA PANDAR correlates with poor prognosis and promotes tumorigenesis in hepatocellular carcinoma. Biomed Pharmacother. 72:113–118. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Xiong XD, Ren X, Cai MY, Yang JW, Liu X and Yang JM: Long non-coding RNAs: An emerging powerhouse in the battle between life and death of tumor cells. Drug Resist Updat. 26:28–42. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Shi Y, Liu Y, Wang J, Jie D, Yun T, Li W, Yan L, Wang K and Feng J: Downregulated long noncoding RNA BANCR promotes the proliferation of colorectal cancer cells via downregualtion of p21 expression. PLoS One. 10:e01226792015. View Article : Google Scholar : PubMed/NCBI

12 

Smolle M, Uranitsch S, Gerger A, Pichler M and Haybaeck J: Current status of long non-coding RNAs in human cancer with specific focus on colorectal cancer. Int J Mol Sci. 15:13993–14013. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Xu Q, Deng F, Qin Y, Zhao Z, Wu Z, Xing Z, Ji A and Wang QJ: Long non-coding RNA regulation of epithelial-mesenchymal transition in cancer metastasis. Cell Death Dis. 7:e22542016. View Article : Google Scholar : PubMed/NCBI

14 

Ma MZ, Chu BF, Zhang Y, Weng MZ, Qin YY, Gong W and Quan ZW: Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p. Cell Death Dis. 6:e15832015. View Article : Google Scholar : PubMed/NCBI

15 

Bergmann JH and Spector DL: Long non-coding RNAs: Modulators of nuclear structure and function. Curr Opin Cell Biol. 26:10–18. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Hao QQ, Chen GY, Zhang JH, Sheng JH and Gao Y: Diagnostic value of long noncoding RNAs for hepatocellular carcinoma: A PRISMA-compliant meta-analysis. Medicine (Baltimore). 96:e74962017. View Article : Google Scholar : PubMed/NCBI

17 

Wei MM and Zhou GB: Long non-coding RNAs and their roles in non-small-cell lung cancer. Genomics Proteomics Bioinformatics. 14:280–288. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Garajov I, Ferracin M, Porcellini E, Palloni A, Abbati F, Biasco G and Brandi G: Non-coding RNAs as predictive biomarkers to current treatment in metastatic colorectal cancer. In J Mol Sci. 18:15472017. View Article : Google Scholar

19 

Fang Y and Fullwood MJ: Roles, functions, and mechanisms of long non-coding RNAs in cancer. Genomics Proteomics Bioinformatics. 14:42–54. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Ding J, Lu B, Wang J, Wang J, Shi Y, Lian Y, Zhu Y, Wang J, Fan Y, Wang Z, et al: Long non-coding RNA Loc554202 induces apoptosis in colorectal cancer cells via the caspase cleavage cascades. J Exp Clin Cancer Res. 34:1002015. View Article : Google Scholar : PubMed/NCBI

21 

Xie X, Tang B, Xiao YF, Xie R, Li BS, Dong H, Zhou JY and Yang SM: Long non-coding RNAs in colorectal cancer. Oncotarget. 7:5226–5239. 2016.PubMed/NCBI

22 

Ragusa M, Barbagallo C, Statello L, Condorelli AG, Battaglia R, Tamburello L, Barbagallo D, Di Pietro C and Purrello M: Non-coding landscapes of colorectal cancer. World J Gastroenterol. 21:11709–11739. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Xu MD, Qi P and Du X: Long non-coding RNAs in colorectal cancer: Implications for pathogenesis and clinical application. Mod Pathol. 27:1310–1320. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Cao J: The functional role of long non-coding RNAs and epigenetics. Biol Proced Online. 16:112014. View Article : Google Scholar : PubMed/NCBI

25 

Lizarbe MA, Calle-Espinosa J, Fernández-Lizarbe E, Fernández-Lizarbe S, Robles MÁ, Olmo N and Turnay J: Colorectal cancer: From the genetic model to posttranscriptional regulation by noncoding RNAs. BioMed Res Int. 2017:73542602017. View Article : Google Scholar : PubMed/NCBI

26 

Li H, Ma SQ, Huang J, Chen XP and Zhou HH: Roles of long noncoding RNAs in colorectal cancer metastasis. Oncotarget. 8:39859–39876. 2017.PubMed/NCBI

27 

Kam Y, Rubinstein A, Naik S, Djavsarov I, Halle D, Ariel I, Gure AO, Stojadinovic A, Pan H, Tsivin V, et al: Detection of a long non-coding RNA (CCAT1) in living cells and human adenocarcinoma of colon tissues using FIT-PNA molecular beacons. Cancer Lett. 352:90–96. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Wang J, Song YX, Ma B, Wang JJ, Sun JX, Chen XW, Zhao JH, Yang YC and Wang ZN: Regulatory roles of non-coding RNAs in colorectal cancer. Int J Mol Sci. 16:19886–19919. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Liu XH, Sun M, Nie FQ, Ge YB, Zhang EB, Yin DD, Kong R, Xia R, Lu KH, Li JH, et al: Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Mol Cancer. 13:922014. View Article : Google Scholar : PubMed/NCBI

30 

Svoboda M, Slyskova J, Schneiderova M, Makovicky P, Bielik L, Levy M, Lipska L, Hemmelova B, Kala Z, Protivankova M, et al: HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. Carcinogenesis. 35:1510–1515. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Deng J, Yang M, Jiang R, An N, Wang X and Liu B: Long non-coding RNA HOTAIR regulates the proliferation, self-renewal capacity, tumor formation and migration of the cancer stem- like cell (CSC) subpopulation enriched from breast cancer cells. PLoS One. 12:e01708602017. View Article : Google Scholar : PubMed/NCBI

32 

Schmitt AM and Chang HY: Long noncoding RNAs in cancer pathways. Cancer Cell. 29:452–463. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Yang MH, Hu ZY, Xu C, Xie LY, Wang XY, Chen SY and Li ZG: MALAT1 promotes colorectal cancer cell proliferation/migration/invasion via PRKA kinase anchor protein 9. Biochim Biophys Acta. 1852:166–174. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Hu ZY, Wang XY, Guo WB, Xie LY, Huang YQ, Liu YP, Xiao LW, Li SN, Zhu HF, Li ZG, et al: Long non-coding RNA MALAT1 increases AKAP-9 expression by promoting SRPK1-catalyzed SRSF1 phosphorylation in colorectal cancer cells. Oncotarget. 7:11733–11743. 2016.PubMed/NCBI

35 

Ye LC, Zhu X, Qiu JJ, Xu J and Wei Y: Involvement of long non-coding RNA in colorectal cancer: From benchtop to bedside (Review). Oncol Lett. 9:1039–1045. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Wu L, Jin L, Zhang W and Zhang L: Roles of long non-coding RNA CCAT2 in cervical cancer cell growth and apoptosis. Med Sci Monit. 22:875–879. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Cătană CS, Pichler M, Giannelli G, Mader RM and Berindan-Neagoe I: Non-coding RNAs, the Trojan horse in two-way communication between tumor and stroma in colorectal and hepatocellular carcinoma. Oncotarget. 8:29519–29534. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Han Y, Yang YN, Yuan HH, Zhang TT, Sui H, Wei XL, Liu L, Huang P, Zhang WJ and Bai YX: UCA1, a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution. Pathology. 46:396–401. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Bian Z, Jin L, Zhang J, Yin Y, Quan C, Hu Y, Feng Y, Liu H, Fei B, Mao Y, et al: LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p. Sci Rep. 6:238922016. View Article : Google Scholar : PubMed/NCBI

40 

Wang F, Li X, Xie X, Zhao L and Chen W: UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. FEBS Lett. 582:1919–1927. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Zhang A, Zhao JC, Kim J, Fong KW, Yang YA, Chakravarti D, Mo YY and Yu J: LncRNA HOTAIR enhances the androgen-receptor- mediated transcriptional program and drives castration-resistant prostate cancer article LncRNA HOTAIR enhances the androgen- receptor-mediated transcriptional program and drives castration-resistant prostate. Cell Rep. 13:209–221. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Shen P, Pichler M, Chen M, Calin GA and Ling H: To wnt or lose: The missing non-coding linc in colorectal cancer. Int J Mol Sci. 18:20032017. View Article : Google Scholar

43 

Liu T, Zhang X, Yang YM, Du LT and Wang CX: Increased expression of the long noncoding RNA CRNDE-h indicates a poor prognosis in colorectal cancer, and is positively correlated with IRX5 mRNA expression. Onco Targets Ther. 9:1437–1448. 2016.PubMed/NCBI

44 

Ding J, Li J, Wang H, Tian Y, Xie M, He X, Ji H, Ma Z, Hui B, Wang K and Ji G: Long noncoding RNA CRNDE promotes colorectal cancer cell proliferation via epigenetically silencing DUSP5/CDKN1A expression. Cell Death Dis. 8:e29972017. View Article : Google Scholar : PubMed/NCBI

45 

Han P, Li JW, Zhang BM, Lv JC, Li YM, Gu XY, Yu ZW, Jia YH, Bai XF, Li L, et al: The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling. Mol Cancer. 16:92017. View Article : Google Scholar : PubMed/NCBI

46 

Zhao B, Lu M, Wang D, Li H and He X: Genome-wide identification of long noncoding RNAs in human intervertebral disc degeneration by RNA sequencing. BioMed Res Int. 2016:36848752016. View Article : Google Scholar : PubMed/NCBI

47 

Zhao B, Hou X and Zhan H: Long non-coding RNA PCAT-1 over-expression promotes proliferation and metastasis in non-small cell lung cancer cells. Int J Clin Exp Med. 8:18482–18487. 2015.PubMed/NCBI

48 

Ge X, Chen Y, Liao X, Liu D, Li F, Ruan H and Jia W: Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer. Med Oncol. 30:5882013. View Article : Google Scholar : PubMed/NCBI

49 

Qiao L, Liu X, Tang Y, Zhao Z, Zhang J and Feng Y: Down regulation of the long non-coding RNA PCAT-1 induced growth arrest and apoptosis of colorectal cancer cells. Life Sci. 188:37–44. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Wang Y, Xue S, Liu X, Liu H, Hu T, Qiu X, Zhang J and Lei M: Analyses of Long Non-Coding RNA and mRNA profiling using RNA sequencing during the pre-implantation phases in pig endometrium. Sci Rep. 6:202382016. View Article : Google Scholar : PubMed/NCBI

51 

Ariel I, Miao HQ, Ji XR, Schneider T, Roll D, de Groot N, Hochberg A and Ayesh S: Imprinted H19 oncofetal RNA is a candidate tumour marker for hepatocellular carcinoma. Mol Pathol. 51:21–25. 1998. View Article : Google Scholar : PubMed/NCBI

52 

Schwarzenbach H: Biological and clinical relevance of H19 in colorectal cancer patients. EBioMedicine. 13:9–10. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Cui H, Onyango P, Brandenburg S, Wu Y, Hsieh CL and Feinberg AP: Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res. 62:6442–6446. 2002.PubMed/NCBI

54 

Kino T, Hurt DE, Ichijo T, Nader N and Chrousos GP: Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor. Sci Signal. 3:ra82010. View Article : Google Scholar : PubMed/NCBI

55 

Saus E, Brunet-Vega A, Iraola-Guzmán S, Pegueroles C, Gabaldón T and Pericay C: Long non-coding RNAs as potential novel prognostic biomarkers in colorectal cancer. Front Genet. 7:542016. View Article : Google Scholar : PubMed/NCBI

56 

Kishikawa T, Otsuka M, Ohno M, Yoshikawa T, Takata A and Koike K: Circulating RNAs as new biomarkers for detecting pancreatic cancer. World J Gastroenterol. 21:8527–8540. 2015. View Article : Google Scholar : PubMed/NCBI

57 

Dong L, Lin W, Qi P, Xu MD, Wu X, Ni S, Huang D, Weng WW, Tan C, Sheng W, et al: Circulating long RNAs in serum extracellular vesicles: Their characterization and potential application as biomarkers for diagnosis of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 25:1158–1166. 2016. View Article : Google Scholar : PubMed/NCBI

58 

Gutschner T, Hämmerle M, Eissmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, et al: The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res. 73:1180–1189. 2013. View Article : Google Scholar : PubMed/NCBI

59 

Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, et al: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 464:1071–1076. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Zheng HT, Shi DB, Wang YW, Li XX, Xu Y, Tripathi P, Gu WL, Cai GX and Cai SJ: High expression of lncRNA MALAT1 suggests a biomarker of poor prognosis in colorectal cancer. Int J Clin Exp Pathol. 7:3174–3181. 2014.PubMed/NCBI

61 

Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, et al: Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res. 71:6320–6326. 2011. View Article : Google Scholar : PubMed/NCBI

62 

Yang Y, Zhao L, Lei L, Lau WB, Lau B, Yang Q, Le X, Yang H, Wang C, Luo Z, et al: LncRNAs: The bridge linking RNA and colorectal cancer. Oncotarget. 8:12517–12532. 2017.PubMed/NCBI

63 

Cao Y, Shi H, Ren F, Jia Y and Zhang R: Long non-coding RNA CCAT1 promotes metastasis and poor prognosis in epithelial ovarian cancer. Exp Cell Res. 359:185–194. 2017. View Article : Google Scholar : PubMed/NCBI

64 

Xing Z, Lin A, Li C, Liang K, Wang S, Liu Y, Park PK, Qin L, Wei Y, Hawke DH, et al: lncRNA directs cooperative epigenetic regulation downstream of chemokine signals. Cell. 159:1110–1125. 2014. View Article : Google Scholar : PubMed/NCBI

65 

Wan L, Zhang L, Fan K, Cheng ZX, Sun QC and Wang JJ: Knockdown of long noncoding RNA PCAT6 inhibits proliferation and invasion in lung cancer cells. Oncol Res. 24:161–170. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Siddiqui H, Al-Ghafari A, Choudhry H and Al Doghaither H: Roles of long non-coding RNAs in colorectal cancer tumorigenesis: A Review. Mol Clin Oncol 11: 167-172, 2019.
APA
Siddiqui, H., Al-Ghafari, A., Choudhry, H., & Al Doghaither, H. (2019). Roles of long non-coding RNAs in colorectal cancer tumorigenesis: A Review. Molecular and Clinical Oncology, 11, 167-172. https://doi.org/10.3892/mco.2019.1872
MLA
Siddiqui, H., Al-Ghafari, A., Choudhry, H., Al Doghaither, H."Roles of long non-coding RNAs in colorectal cancer tumorigenesis: A Review". Molecular and Clinical Oncology 11.2 (2019): 167-172.
Chicago
Siddiqui, H., Al-Ghafari, A., Choudhry, H., Al Doghaither, H."Roles of long non-coding RNAs in colorectal cancer tumorigenesis: A Review". Molecular and Clinical Oncology 11, no. 2 (2019): 167-172. https://doi.org/10.3892/mco.2019.1872
Copy and paste a formatted citation
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Spandidos Publications style
Siddiqui H, Al-Ghafari A, Choudhry H and Al Doghaither H: Roles of long non-coding RNAs in colorectal cancer tumorigenesis: A Review. Mol Clin Oncol 11: 167-172, 2019.
APA
Siddiqui, H., Al-Ghafari, A., Choudhry, H., & Al Doghaither, H. (2019). Roles of long non-coding RNAs in colorectal cancer tumorigenesis: A Review. Molecular and Clinical Oncology, 11, 167-172. https://doi.org/10.3892/mco.2019.1872
MLA
Siddiqui, H., Al-Ghafari, A., Choudhry, H., Al Doghaither, H."Roles of long non-coding RNAs in colorectal cancer tumorigenesis: A Review". Molecular and Clinical Oncology 11.2 (2019): 167-172.
Chicago
Siddiqui, H., Al-Ghafari, A., Choudhry, H., Al Doghaither, H."Roles of long non-coding RNAs in colorectal cancer tumorigenesis: A Review". Molecular and Clinical Oncology 11, no. 2 (2019): 167-172. https://doi.org/10.3892/mco.2019.1872
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