Acute lymphoblastic leukemia in an adolescent presenting with acute hepatic failure: A case report
- Authors:
- Ruo‑Lan Gu
- Ming Xiang
- Jing Suo
- Jing Yuan
View Affiliations
Affiliations: Department of Hematology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China
- Published online on: June 12, 2019 https://doi.org/10.3892/mco.2019.1877
-
Pages:
135-138
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Abstract
This case report describes a case of an unusual initial presentation of acute lymphoblastic leukemia in a previously healthy 15‑year‑old boy. He initially presented with a 6‑day history of tiredness, decreased oral intake, nausea, vomiting, and jaundice (yellow sclera and dark urine) with evidence of acute hepatic failure, presenting as an increase in alanine aminotransferase (ALT)/aspartate aminotransferase (AST)/total bilirubin and a decrease in prothrombin activity. A complete serological evaluation for liver disease was negative. The levels of serum AST and ALT declined following hepatoprotective treatment. Bone marrow biopsy was diagnostic, revealing 68.15% blasts with markers consistent with acute B‑cell lymphoblastic leukemia. This case report emphasizes that acute hepatic failure may be the initial presentation of ALL in an adolescent.
View References
|
1
|
Inaba H, Greaves M and Mullighan CG: Acute
lymphoblastic leukaemia. Lancet. 381:1943–1955. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Vallacha A, Haider G, Raja W and Kumar D:
Remission rate of acute lymphoblastic leukemia (ALL) in adolescents
and young adults (AYA). J Coll Physicians Surg Pak. 28:118–121.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Litten JB, Rodríguez MM and Maniaci V:
Acute lymphoblastic leukemia presenting in fulminant hepatic
failure. Pediatr Blood Cancer. 47:842–845. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Kader A, Vara R, Egberongbe Y, Height S
and Dhawan A: Leukaemia presenting with fulminant hepatic failure
in a child. Eur J Pediatr. 163:628–629. 2004.PubMed/NCBI
|
|
5
|
Heincelman M, Karakala N and Rockey DC:
Acute lymphoblastic leukemia in a young adult presenting as
hepatitis and acute kidney injury. J Investig Med High Impact Case
Rep. Sep 22–2016.(Epub ahead of print). doi:
10.1177/2324709616665866. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Segal I, Rassekh SR, Bond MC, Senger C and
Schreiber RA: Abnormal liver transaminases and conjugated
hyperbilirubinemia at presentation of acute lymphoblastic leukemia.
Pediatr Blood Cancer. 434–439. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Ribera JM, Ribera J and Genescà E:
Treatment of adolescent and young adults with acute lymphoblastic
leukemia. Mediterr J Hematol Infect Dis. 6:e20140522014. View Article : Google Scholar : PubMed/NCBI
|
