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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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October-2019 Volume 11 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Case Report Open Access

Successful resection of a granulocyte colony‑stimulating factor‑producing carcinoma of the pancreas: A case report

  • Authors:
    • Takayuki Akasaki
    • Takahiro Einama
    • Keita Tashiro
    • Hiromi Nagata
    • Kenji Yamazaki
    • Makoto Nishikawa
    • Mayumi Hoshikawa
    • Akifumi Kimura
    • Takuji Noro
    • Sho Ogata
    • Suefumi Aosasa
    • Yoshiki Kajiwara
    • Eiji Shinto
    • Yoshihisa Yaguchi
    • Shuichi Hiraki
    • Hironori Tsujimoto
    • Kazuo Hase
    • Hideki Ueno
    • Junji Yamamoto
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, National Defense Medical College, Tokorozawa, Saitama 359‑8513, Japan, Department of Pathology, National Defense Medical College, Tokorozawa, Saitama 359‑8513, Japan
    Copyright: © Akasaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 359-363
    |
    Published online on: July 22, 2019
       https://doi.org/10.3892/mco.2019.1902
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Abstract

Granulocyte colony‑stimulating factor (G‑CSF) is a naturally occurring glycoprotein that stimulates the proliferation of precursor cells in the bone marrow and their maturation into fully differentiated neutrophils. G‑CSF‑producing cancers rarely occur in the digestive system, particularly the pancreas. Herein we report the rare case of a G‑CSF‑producing pancreatic carcinoma associated with severe anemia due to bleeding in the duodenum, which was successfully treated with surgery. A 79 year‑old man presented with epigastralgia and anemia at our institution. Esophagogastroduodenoscopy revealed a duodenal tumor, which was diagnosed as a poorly differentiated adenocarcinoma. To control breeding, subtotal stomach‑preserving pancreaticoduodenectomy was performed. The excised tumor measured 86x55x54 mm. It was primarily located in the pancreas and compressed the pancreatic parenchyma and main bile duct. It comprised poorly differentiated adenocarcinoma, and prominent neutrophil infiltration was noted around the tumor. Immunohistochemical examination revelaed that the tumor was positive for G‑CSF expression. Based on these results, a final diagnosis of G‑CSF‑producing primary pancreatic cancer was made. At 18 months following surgery, the patient was alive without recurrence.
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1 

Joshita S, Nakazawa K, Koike S, Kamijo A, Matsubayashi K, Miyabayashi H, Furuta K, Kitano K, Yoshizawa K and Tanaka E: A case of granulocyte-colony stimulating factor-producing hepatocellular carcinoma confirmed by immunohistochemistry. J Korean Med Sci. 25:476–480. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Nakajima A, Takahashi H, Inamori M, Abe Y, Kobayashi N, Kubota K and Yamanaka S: Anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor: A case report. J Med Case Rep. 2:3912008. View Article : Google Scholar : PubMed/NCBI

3 

Asano S, Urabe A, Okabe T, Sato N and Kondo Y: Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood. 49:845–852. 1977.PubMed/NCBI

4 

Ohwada S, Miyamoto Y, Fujii T, Kuribara T, Teshigawara O, Oyama T, Ishii H, Joshita T and Izuo M: Colony stimulating factor producing carcinoma of the pancreas-a case report. Gan No Rinsho. 35:523–527. 1989.(In Japanese). PubMed/NCBI

5 

Kawakami H, Kuwatani M, Fujiya Y, Uebayashi M, Konishi K, Makiyama H, Hashino S, Kubota K, Itoh T and Asaka M: A case of granulocyte-colony stimulating factor producing ductal adenocarcinoma of the pancreas. Nihon Shokakibyo Gakkai ZasshiZasshi. 104:233–238. 2007.(In Japanese).

6 

Murata T, Terasaki M, Sakaguchi K, Okubo M, Fukami Y, Nishimae K, Kitayama Y and Hoshi S: A case of anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor. Clin J Gastroenterol. 2:109–114. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Ikeda S, Okubo K, Shibahara H, Narita M, Morita K, Takeuchi A, Kanazawa H, Ito T, Nishimura D and Katada N: An autopsy of G-CSF-producing anaplastic carcinoma of the pancreas with impaired accumulation on FDG-PET after S-1 chemotherapy. Gan To Kagaku Ryoho. 40:789–792. 2013.(In Japanese). PubMed/NCBI

8 

Kitade H, Yanagida H, Yamada M, Satoi S, Yoshioka K, Shikata N and Kon M: Granulocyte-colony stimulating factor producing anaplastic carcinoma of the pancreas treated by distal pancreatectomy and chemotherapy: Report of a case. Surg Case Rep. 1:462015. View Article : Google Scholar : PubMed/NCBI

9 

Hayashi H, Eguchi N, Sumimoto K, Matsumoto K, Azakami T, Sumida T, Tamura T, Sumii M, Uraoka N and Shimamoto F: Autopsy of anaplastic carcinoma of the pancreas producing granulocyte colony-stimulating factor. Nihon Shokakibyo Gakkai ZasshiZasshi. 113:1408–1415. 2016.(In Japanese).

10 

Vinzens S, Zindel J, Zweifel M, Rau T Gloor B and Wochner A: Granulocyte colony-stimulating factor producing anaplastic carcinoma of the pancreas: Case report and review of the literature. Anticancer Res. 37:223–228. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Seki H, Yasui N, Shimada A, Matsumoto H and Domoto H: Resection of a granulocyte colony-stimulating factor-producing anaplastic carcinoma of the pancreas, associated with humoral hypercalcemia of malignancy. Gan To Kagaku Ryoho. 45:859–862. 2018.(In Japanese). PubMed/NCBI

12 

Cavalloni G, Sarotto I, Pignochino Y, Gammaitoni L, Migliardi G, Sgro L, Piacibello W, Risio M, Aglietta M and Leone F: Granulocyte-colony stimulating factor upregulates ErbB2 expression on breast cancer cell lines and converts primary resistance to trastuzumab. Anticancer Drugs. 19:689–696. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Akasaki T, Einama T, Tashiro K, Nagata H, Yamazaki K, Nishikawa M, Hoshikawa M, Kimura A, Noro T, Ogata S, Ogata S, et al: Successful resection of a granulocyte colony‑stimulating factor‑producing carcinoma of the pancreas: A case report. Mol Clin Oncol 11: 359-363, 2019.
APA
Akasaki, T., Einama, T., Tashiro, K., Nagata, H., Yamazaki, K., Nishikawa, M. ... Yamamoto, J. (2019). Successful resection of a granulocyte colony‑stimulating factor‑producing carcinoma of the pancreas: A case report. Molecular and Clinical Oncology, 11, 359-363. https://doi.org/10.3892/mco.2019.1902
MLA
Akasaki, T., Einama, T., Tashiro, K., Nagata, H., Yamazaki, K., Nishikawa, M., Hoshikawa, M., Kimura, A., Noro, T., Ogata, S., Aosasa, S., Kajiwara, Y., Shinto, E., Yaguchi, Y., Hiraki, S., Tsujimoto, H., Hase, K., Ueno, H., Yamamoto, J."Successful resection of a granulocyte colony‑stimulating factor‑producing carcinoma of the pancreas: A case report". Molecular and Clinical Oncology 11.4 (2019): 359-363.
Chicago
Akasaki, T., Einama, T., Tashiro, K., Nagata, H., Yamazaki, K., Nishikawa, M., Hoshikawa, M., Kimura, A., Noro, T., Ogata, S., Aosasa, S., Kajiwara, Y., Shinto, E., Yaguchi, Y., Hiraki, S., Tsujimoto, H., Hase, K., Ueno, H., Yamamoto, J."Successful resection of a granulocyte colony‑stimulating factor‑producing carcinoma of the pancreas: A case report". Molecular and Clinical Oncology 11, no. 4 (2019): 359-363. https://doi.org/10.3892/mco.2019.1902
Copy and paste a formatted citation
x
Spandidos Publications style
Akasaki T, Einama T, Tashiro K, Nagata H, Yamazaki K, Nishikawa M, Hoshikawa M, Kimura A, Noro T, Ogata S, Ogata S, et al: Successful resection of a granulocyte colony‑stimulating factor‑producing carcinoma of the pancreas: A case report. Mol Clin Oncol 11: 359-363, 2019.
APA
Akasaki, T., Einama, T., Tashiro, K., Nagata, H., Yamazaki, K., Nishikawa, M. ... Yamamoto, J. (2019). Successful resection of a granulocyte colony‑stimulating factor‑producing carcinoma of the pancreas: A case report. Molecular and Clinical Oncology, 11, 359-363. https://doi.org/10.3892/mco.2019.1902
MLA
Akasaki, T., Einama, T., Tashiro, K., Nagata, H., Yamazaki, K., Nishikawa, M., Hoshikawa, M., Kimura, A., Noro, T., Ogata, S., Aosasa, S., Kajiwara, Y., Shinto, E., Yaguchi, Y., Hiraki, S., Tsujimoto, H., Hase, K., Ueno, H., Yamamoto, J."Successful resection of a granulocyte colony‑stimulating factor‑producing carcinoma of the pancreas: A case report". Molecular and Clinical Oncology 11.4 (2019): 359-363.
Chicago
Akasaki, T., Einama, T., Tashiro, K., Nagata, H., Yamazaki, K., Nishikawa, M., Hoshikawa, M., Kimura, A., Noro, T., Ogata, S., Aosasa, S., Kajiwara, Y., Shinto, E., Yaguchi, Y., Hiraki, S., Tsujimoto, H., Hase, K., Ueno, H., Yamamoto, J."Successful resection of a granulocyte colony‑stimulating factor‑producing carcinoma of the pancreas: A case report". Molecular and Clinical Oncology 11, no. 4 (2019): 359-363. https://doi.org/10.3892/mco.2019.1902
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