Multicenter study of zoledronic acid administration in non‑small‑cell lung cancer patients with bone metastasis: Thoracic Oncology Research Group (TORG) 1017

Nakahara,Yoshiro; Hosomi,Yukio; Shibuya,Masahiko; Mitsufuji,Hisashi; Katagiri,Masato; Naoki,Katsuhiko; Soejima,Kenzo; Nogami,Naoyuki; Nagase,Seisuke; Nishikawa,Masanori; Minato,Koichi; Takiguchi,Yuichi; Seki,Nobuhiko; Yamada,Kouzo; Seto,Takashi; Okamoto,Hiroaki

doi:10.3892/mco.2019.1903

October-2019 Volume 11 Issue 4

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October-2019 Volume 11 Issue 4

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Article Open Access

Multicenter study of zoledronic acid administration in non‑small‑cell lung cancer patients with bone metastasis: Thoracic Oncology Research Group (TORG) 1017

Authors:
- Yoshiro Nakahara
- Yukio Hosomi
- Masahiko Shibuya
- Hisashi Mitsufuji
- Masato Katagiri
- Katsuhiko Naoki
- Kenzo Soejima
- Naoyuki Nogami
- Seisuke Nagase
- Masanori Nishikawa
- Koichi Minato
- Yuichi Takiguchi
- Nobuhiko Seki
- Kouzo Yamada
- Takashi Seto
- Hiroaki Okamoto
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Affiliations: Department of Thoracic Oncology and Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo 113‑0021, Japan, Kitasato University School of Nursing, Kanagawa 252‑0329, Japan, School of Allied Health Sciences, Kitasato University, Kanagawa 252‑0373, Japan, Department of Respiratory Medicine, Kitasato University School of Medicine, Kanagawa 252‑0374, Japan, Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo 160‑8582, Japan, Department of Thoracic Oncology and Medicine, National Hospital Organization Shikoku Cancer Center, Ehime 791‑0280, Japan, Respiratory Disease Center, International University of Health and Welfare, Mita Hospital, Tokyo 108‑8329, Japan, Department of Respiratory Medicine, Fujisawa City Hospital, Kanagawa 251‑8550, Japan, Department of Respiratory Medicine, Gunma Prefectural Cancer Center, Gunma 373‑8550, Japan, Department of Medical Oncology, Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan, Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173‑8606, Japan, Department of Thoracic Oncology, Kanagawa Cancer Center, Kanagawa 241‑8515, Japan, Department of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811‑1395, Japan, Department of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, Kanagawa 240‑8555, Japan

Copyright: © Nakahara et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 349-353
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Published online on: July 23, 2019

https://doi.org/10.3892/mco.2019.1903
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Abstract

Skeletal‑related events (SREs) may occur at the time of first diagnosis in 20‑30% of lung cancer patients with bone metastases. Several clinical trials have shown that zoledronic acid (ZA) is effective for decreasing SREs. The main objective of the present study was to discuss clinical data of ZA and compare the frequency of SREs with previous reports. All patients with non‑small‑cell lung cancer (NSCLC) with metastatic bone disease who were administered ZA at least twice between January 2008 and December 2009 were eligible for inclusion in the study. In total, 198 consecutive patients were identified. The median duration of ZA administration was 106 days [95% confidence interval (CI), 92‑133 days], and the median number of ZA administrations was 4 (range, 2‑41). The median time to first SRE in patients who experienced SRE following ZA treatment was 202 days (95% CI, 156‑264 days). Among the 78 patients who had already experienced SRE prior to ZA treatment, 35 (45%) experienced SRE subsequently after starting ZA treatment. On the other hand, among the 120 patients without a history of SRE before starting ZA treatment, 42 (35%) experienced SRE after the start of ZA administration (P=0.16). No osteonecrosis of the jaw (ONJ) was reported in any of the patients. The present study revealed that ZA had a certain level of efficacy regardless of the presence or absence of prior SREs. However, the duration of ZA therapy was short in this study; further accumulation of data on the long‑term prognosis and incidence rates of ONJ and other late complications of ZA therapy seems to be particularly important.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Multicenter study of zoledronic acid administration in non‑small‑cell lung cancer patients with bone metastasis: Thoracic Oncology Research Group (TORG) 1017

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