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Article

Survival outcome of combined GnRH agonist and tamoxifen is comparable to that of sequential adriamycin and cyclophosphamide chemotherapy plus tamoxifen in premenopausal patients with early breast cancer

  • Authors:
    • Doonyapat Sa‑Nguanraksa
    • Thitikon Krisorakun
    • Wanee Pongthong
    • Pornchai O‑Charoenrat
  • View Affiliations / Copyright

    Affiliations: Division of Head Neck and Breast Surgery, Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
  • Pages: 517-522
    |
    Published online on: August 20, 2019
       https://doi.org/10.3892/mco.2019.1913
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Abstract

Survival outcome of ovarian suppression plus tamoxifen has been shown to be comparable with chemotherapy in premenopausal women; however, there are a few previous studies that compared this treatment to the current standard adriamycin and cyclophosphamide (AC) regimen. The aim of the present study was to compare the survival outcome of gonadotropin‑releasing hormone (GnRH) agonist plus tamoxifen (GnRH‑TAM) and chemotherapy AC plus tamoxifen (AC‑TAM) in premenopausal patients with early breast cancer who were hormone receptor‑positive. Premenopausal patients with early breast cancer who were treated at The Siriraj Hospital between January 2005 and December 2015 were retrospectively recruited. The inclusion criteria included newly diagnosed breast cancer, size ≤3 cm, node‑negative and hormone receptor‑positive. All patients received adjuvant systemic therapy and were divided into two groups. In the GnRH‑TAM group, the patients received subcutaneous injection of 10.8 mg of goserelin every 3 months for 2‑3 years and TAM (20 mg/day) for 5 years. In the AC‑TAM group, AC was administered every 3 weeks for 4 cycles followed by TAM (20 mg/day) for 5 years. In total, 40 patients received GnRH‑TAM and 130 patients received AC‑TAM. The mean age at diagnosis was 44.4±6.3 years while the median follow up time was 77 (36‑167) months. There was no mortality in either group and no significant difference in disease‑free survival between the two groups. No adverse effect occurred and good compliance was observed in all patients who received GnRH‑TAM. Treatment with GnRH‑TAM resulted in a comparable survival outcome and better quality of life compared with AC‑TAM.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Tan BK, Lim GH, Czene K, Hall P and Chia KS: Do Asian breast cancer patients have poorer survival than their western counterparts? A comparison between Singapore and Stockholm. Breast Cancer Res. 11:R42009. View Article : Google Scholar : PubMed/NCBI

3 

Sa-Nguanraksa D, Chuangsuwanich T, Pongpruttipan T, Kummalue T, Rojananin S, Ratanawichhitrasin A, Prasarttong-Osoth P, Chuthatisith S, Pisarnturakit P, Aeumrithaicharoenchok W, et al: Vascular endothelial growth factor 634G/C polymorphism is associated with increased breast cancer risk and aggressiveness. Mol Med Rep. 8:1242–1250. 2013. View Article : Google Scholar : PubMed/NCBI

4 

National Cancer Institute, . Hospital-Based Cancer Registry 2017. http://www.nci.go.th/th/File_download/Nci%20Cancer%20Registry/HOSPITAL-BASED%202016%20Revise%204%20Final.pdfDecember 4–2018

5 

Lertsanguansinchai P, Chottetanaprasith T, Chatamra K, Sampatanukul P, Wannakrairot P, Rojpornpradit P, Shotelersuk K, Lertbutsayanukul C, Boonjunwetwat D and Vajragupta L: Estrogen and progesterone receptors status in Thai female breast cancer patients: An analysis of 399 cases at King Chulalongkorn Memorial Hospital. J Med Assoc Thai. 85 (Suppl 1):S193–S202. 2002.PubMed/NCBI

6 

Johnston SJ and Cheung KL: Endocrine therapy for breast cancer: A model of hormonal manipulation. Oncol Ther. 6:141–156. 2018. View Article : Google Scholar

7 

National Comprehensive Cancer Network, . NCCN Clinical Practice Guidelines in Oncology (NCCN GuidelinesR). Breast Cancer. https://www.nccn.org/professionals/physician_gls/pdf/breast.pdfDecember 4–2018

8 

Coates AS, Keshaviah A, Thürlimann B, Mouridsen H, Mauriac L, Forbes JF, Paridaens R, Castiglione-Gertsch M, Gelber RD, Colleoni M, et al: Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: Update of study BIG 1–98. J Clin Oncol. 25:486–492. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Arimidex, Tamoxifen, Alone or in Combination (ATAC) Trialists' Group, ; Forbes JF, Cuzick J, Buzdar A, Howell A, Tobias JS and Baum M: Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncol. 9:45–53. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Ovarian ablation in early breast cancer, . Overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group. Lancet. 348:1189–1196. 1996. View Article : Google Scholar : PubMed/NCBI

11 

Adjuvant ovarian ablation versus CMF chemotherapy in premenopausal women with pathological stage II breast carcinoma, . The Scottish trial. Scottish Cancer Trials Breast Group and ICRF Breast Unit, Guy's Hospital, London. Lancet. 341:1293–1298. 1993.PubMed/NCBI

12 

Ejlertsen B, Dombernowsky P, Mouridsen HT and Kamby C; American Society of Clinical Oncology, : Comparable effect of ovarian (OA) and CMF chemotherapy in premenopausal hormonal receptor positive breast cancer patients (PRP). Proc Am Soc Clin Oncol. 18:pp. 66a(abstract). 1999, https://www.tib.eu/en/search/id/BLCP%3ACN030034114/Comparable-Effect-of-Ovarian-Ablation-OA-and-CMF

13 

Boccardo F, Rubagotti A, Amoroso D, Mesiti M, Romeo D, Sismondi P, Giai M, Genta F, Pacini P, Distante V, et al: Cyclophosphamide, methotrexate, and fluorouracil versus tamoxifen plus ovarian suppression as adjuvant treatment of estrogen receptor-positive pre-/perimenopausal breast cancer patients: Results of the Italian Breast Cancer Adjuvant Study Group 02 randomized trial. simpleboccardo@hp380.ist.unige.it. J Clin Oncol. 18:2718–2727. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Jakesz R, Hausmaninger H, Samonigg H, Kubista E, Depisch D, Fridrik M, Stierer M, Gnant M, Steger G, Kolb R, et al: Comparison of adjuvant therapy with tamoxifen and goserelin vs. CMF in premenopausal stage I and II hormone-responsive breast cancer patients: Four-year results of Austrian Breast Cancer Study Group (ABCSG) trial 5. Eur J Cancer. 35 (Suppl 4):S831999. View Article : Google Scholar

15 

Jakesz R, Hausmaninger H, Kubista E, Gnant M, Menzel C, Bauernhofer T, Seifert M, Haider K, Mlineritsch B, Steindorfer P, et al: Randomized adjuvant trial of tamoxifen and goserelin versus cyclophosphamide, methotrexate, and fluorouracil: Evidence for the superiority of treatment with endocrine blockade in premenopausal patients with hormone-responsive breast cancer-Austrian Breast and Colorectal Cancer Study Group Trial 5. J Clin Oncol. 20:4621–4627. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Roché H, Kerbrat P, Bonneterre J, Fargeot P, Fumoleau P, Monnier A, Clavère P, Goudier MJ, Chollet P, Guastalla JP and Serin D: Complete hormonal blockade versus epirubicin-based chemotherapy in premenopausal, one to three node-positive, and hormone-receptor positive, early breast cancer patients: 7-year follow-up results of French Adjuvant Study Group 06 randomised trial. Ann Oncol. 17:1221–1227. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Francis PA, Regan MM, Fleming GF, Láng I, Ciruelos E, Bellet M, Bonnefoi HR, Climent MA, Da Prada GA, Burstein HJ, et al: Adjuvant ovarian suppression in premenopausal breast cancer. N Engl J Med. 372:436–446. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Bloom HJ and Richardson WW: Histological grading and prognosis in breast cancer; a study of 1,409 cases of which 359 have been followed for 15 years. Br J Cancer. 11:359–377. 1957. View Article : Google Scholar : PubMed/NCBI

19 

Elston CW and Ellis IO: Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up. Histopathology. 19:403–410. 1991. View Article : Google Scholar : PubMed/NCBI

20 

Chow SC, Shao J and Wang H: Sample size calculations in clinical researchMarcel Dekker; New York: 2003

21 

Jonat W, Kaufmann M, Sauerbrei W, Blamey R, Cuzick J, Namer M, Fogelman I, de Haes JC, de Matteis A, Stewart A, et al: Goserelin versus cyclophosphamide, methotrexate, and fluorouracil as adjuvant therapy in premenopausal patients with node-positive breast cancer: The Zoladex Early Breast Cancer Research Association Study. J Clin Oncol. 20:4628–4635. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Kaufmann M, Graf E, Jonat W, Eiermann W, Vescia S, Geberth M, Conrad B, Gademann G, Albert US, Loibl S, et al: A randomised trial of goserelin versus control after adjuvant, risk-adapted chemotherapy in premenopausal patients with primary breast cancer-GABG-IV B-93. Eur J Cancer. 43:2351–2358. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Early Breast Cancer Trialists' Collaborative Group (EBCTCG), : Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet. 365:1687–1717. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Francis PA, Pagani O, Fleming GF, Walley BA, Colleoni M, Láng I, Gómez HL, Tondini C, Ciruelos E, Burstein HJ, et al: Tailoring adjuvant endocrine therapy for premenopausal breast cancer. N Engl J Med. 379:122–137. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Davidson NE, O'Neill AM, Vukov AM, Osborne CK, Martino S, White DR and Abeloff MD: Chemoendocrine therapy for premenopausal women with axillary lymph node-positive, steroid hormone receptor-positive breast cancer: Results from INT 0101 (E5188). J Clin Oncol. 23:5973–5982. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Ejlertsen B, Mouridsen HT, Jensen MB, Bengtsson NO, Bergh J, Cold S, Edlund P, Ewertz M, de Graaf PW, Kamby C and Nielsen DL: Similar efficacy for ovarian ablation compared with cyclophosphamide, methotrexate, and fluorouracil: From a randomized comparison of premenopausal patients with node-positive, hormone receptor-positive breast cancer. J Clin Oncol. 24:4956–4962. 2006. View Article : Google Scholar : PubMed/NCBI

27 

International Breast Cancer Study Group (IBCSG), ; Castiglione-Gertsch M, O'Neill A, Price KN, Goldhirsch A, Coates AS, Colleoni M, Nasi ML, Bonetti M and Gelber RD: Adjuvant chemotherapy followed by goserelin versus either modality alone for premenopausal lymph node-negative breast cancer: A randomized trial. J Natl Cancer Inst. 95:1833–1846. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Kaufmann M, Jonat W, Blamey R, Cuzick J, Namer M, Fogelman I, de Haes JC, Schumacher M and Sauerbrei W; Zoladex Early Breast Cancer Research Association (ZEBRA) Trialists' Group, : Survival analyses from the ZEBRA study. goserelin (Zoladex) versus CMF in premenopausal women with node-positive breast cancer. Eur J Cancer. 39:1711–1717. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Schmid P, Untch M, Kossé V, Bondar G, Vassiljev L, Tarutinov V, Lehmann U, Maubach L, Meurer J, Wallwiener D and Possinger K: Leuprorelin acetate every-3-months depot versus cyclophosphamide, methotrexate, and fluorouracil as adjuvant treatment in premenopausal patients with node-positive breast cancer: The TABLE study. J Clin Oncol. 25:2509–2515. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Thomson CS, Twelves CJ, Mallon EA and Leake RE; Scottish Cancer Trials Breast Group; Scottish Cancer Therapy Network, : Adjuvant ovarian ablation vs. CMF chemotherapy in premenopausal breast cancer patients: Trial update and impact of immunohistochemical assessment of ER status. Breast. 11:419–429. 2002. View Article : Google Scholar : PubMed/NCBI

31 

von Minckwitz G, Graf E, Geberth M, Eiermann W, Jonat W, Conrad B, Brunnert K, Gerber B, Vescia S, Wollert J and Kaufmann M: CMF versus goserelin as adjuvant therapy for node-negative, hormone-receptor-positive breast cancer in premenopausal patients: A randomised trial (GABG trial IV-A-93). Eur J Cancer. 42:1780–1788. 2006. View Article : Google Scholar : PubMed/NCBI

32 

de Haes H, Olschewski M, Kaufmann M, Schumacher M, Jonat W and Sauerbrei W; Zoladex Early Breast Cancer Research Association Trialists Group, : Quality of life in goserelin-treated versus cyclophosphamide + methotrexate + fluorouracil-treated premenopausal and perimenopausal patients with node-positive, early breast cancer: The Zoladex Early Breast Cancer Research Association Trialists Group. J Clin Oncol. 21:4510–4516. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Hürny C, Bernhard J, Coates AS, Castiglione-Gertsch M, Peterson HF, Gelber RD, Forbes JF, Rudenstam CM, Simoncini E, Crivellari D, et al: Impact of adjuvant therapy on quality of life in women with node-positive operable breast cancer. International Breast Cancer Study Group. Lancet. 347:1279–1284. 1996. View Article : Google Scholar : PubMed/NCBI

34 

Nystedt M, Berglund G, Bolund C, Fornander T and Rutqvist LE: Side effects of adjuvant endocrine treatment in premenopausal breast cancer patients: A prospective randomized study. J Clin Oncol. 21:1836–1844. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Boccardo F, Rubagotti A, Amoroso D, Sismondi P, Genta F, Nenci I, Piffanelli A, Farris A, Castagnetta L, Traina A, et al: Chemotherapy versus tamoxifen versus chemotherapy plus tamoxifen in node-positive, oestrogen-receptor positive breast cancer patients. An update at 7 years of the 1st GROCTA (Breast Cancer Adjuvant Chemo-Hormone Therapy Cooperative Group) trial. Eur J Cancer. 28:673–680. 1992. View Article : Google Scholar : PubMed/NCBI

36 

Roché H, Mihura J, de Lafontan B, Reme-Saumon M, Martel P, Dubois JB and Naja A: PP-5-6 castration and tamoxifen versus chemotherapy (FAC) for premenopausal, node and receptors positive breast cancer patients: A randomized trial with a 7 years median follow up. Eur J Cancer. 32 (Suppl 2):S351996. View Article : Google Scholar

37 

Bernhard J, Zahrieh D, Castiglione-Gertsch M, Hürny C, Gelber RD, Forbes JF, Murray E, Collins J, Aebi S, Thürlimann B, et al: Adjuvant chemotherapy followed by goserelin compared with either modality alone: The impact on amenorrhea, hot flashes, and quality of life in premenopausal patients-the International Breast Cancer Study Group Trial VIII. J Clin Oncol. 25:263–270. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Partridge AH, Burstein HJ and Winer EP: Side effects of chemotherapy and combined chemohormonal therapy in women with early-stage breast cancer. J Natl Cancer Inst Monogr. 135–142. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Kim HJ, Lee JS, Park EH, Lim WS, Sei JY, Koh BS, Son BH, Ahn JH, Jeong KH, Kim SB and Ahn SH: Short term results from GHRH analogue use in pre-menopausal breast cancer in Korea. Eur J Surg Oncol. 35:936–941. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Sohn G, Ahn SH, Kim HJ, Son BH, Lee JW, Ko BS, Lee Y, Lee SB and Baek S: Survival outcome of combined GnRH agonist and tamoxifen is comparable to that of sequential adriamycin and cyclophosphamide chemotherapy plus tamoxifen in premenopausal patients with lymph-node-negative, hormone-responsive, HER2-negative, T1-T2 breast cancer. Cancer Res Treat. 48:1351–1362. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Cheng TF, Wang JD and Uen WC: Cost-utility analysis of adjuvant goserelin (Zoladex) and adjuvant chemotherapy in premenopausal women with breast cancer. BMC Cancer. 12:332012. View Article : Google Scholar : PubMed/NCBI

42 

Florescu M, Cinteza M and Vinereanu D: Chemotherapy-induced cardiotoxicity. Maedica (Buchar). 8:59–67. 2013.PubMed/NCBI

43 

Masuda N, Iwata H, Rai Y, Anan K, Takeuchi T, Kohno N, Takei H, Yanagita Y and Noguchi S: Monthly versus 3-monthly goserelin acetate treatment in pre-menopausal patients with estrogen receptor-positive early breast cancer. Breast Cancer Res Treat. 126:443–451. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sa‑Nguanraksa D, Krisorakun T, Pongthong W and O‑Charoenrat P: Survival outcome of combined GnRH agonist and tamoxifen is comparable to that of sequential adriamycin and cyclophosphamide chemotherapy plus tamoxifen in premenopausal patients with early breast cancer. Mol Clin Oncol 11: 517-522, 2019.
APA
Sa‑Nguanraksa, D., Krisorakun, T., Pongthong, W., & O‑Charoenrat, P. (2019). Survival outcome of combined GnRH agonist and tamoxifen is comparable to that of sequential adriamycin and cyclophosphamide chemotherapy plus tamoxifen in premenopausal patients with early breast cancer. Molecular and Clinical Oncology, 11, 517-522. https://doi.org/10.3892/mco.2019.1913
MLA
Sa‑Nguanraksa, D., Krisorakun, T., Pongthong, W., O‑Charoenrat, P."Survival outcome of combined GnRH agonist and tamoxifen is comparable to that of sequential adriamycin and cyclophosphamide chemotherapy plus tamoxifen in premenopausal patients with early breast cancer". Molecular and Clinical Oncology 11.5 (2019): 517-522.
Chicago
Sa‑Nguanraksa, D., Krisorakun, T., Pongthong, W., O‑Charoenrat, P."Survival outcome of combined GnRH agonist and tamoxifen is comparable to that of sequential adriamycin and cyclophosphamide chemotherapy plus tamoxifen in premenopausal patients with early breast cancer". Molecular and Clinical Oncology 11, no. 5 (2019): 517-522. https://doi.org/10.3892/mco.2019.1913
Copy and paste a formatted citation
x
Spandidos Publications style
Sa‑Nguanraksa D, Krisorakun T, Pongthong W and O‑Charoenrat P: Survival outcome of combined GnRH agonist and tamoxifen is comparable to that of sequential adriamycin and cyclophosphamide chemotherapy plus tamoxifen in premenopausal patients with early breast cancer. Mol Clin Oncol 11: 517-522, 2019.
APA
Sa‑Nguanraksa, D., Krisorakun, T., Pongthong, W., & O‑Charoenrat, P. (2019). Survival outcome of combined GnRH agonist and tamoxifen is comparable to that of sequential adriamycin and cyclophosphamide chemotherapy plus tamoxifen in premenopausal patients with early breast cancer. Molecular and Clinical Oncology, 11, 517-522. https://doi.org/10.3892/mco.2019.1913
MLA
Sa‑Nguanraksa, D., Krisorakun, T., Pongthong, W., O‑Charoenrat, P."Survival outcome of combined GnRH agonist and tamoxifen is comparable to that of sequential adriamycin and cyclophosphamide chemotherapy plus tamoxifen in premenopausal patients with early breast cancer". Molecular and Clinical Oncology 11.5 (2019): 517-522.
Chicago
Sa‑Nguanraksa, D., Krisorakun, T., Pongthong, W., O‑Charoenrat, P."Survival outcome of combined GnRH agonist and tamoxifen is comparable to that of sequential adriamycin and cyclophosphamide chemotherapy plus tamoxifen in premenopausal patients with early breast cancer". Molecular and Clinical Oncology 11, no. 5 (2019): 517-522. https://doi.org/10.3892/mco.2019.1913
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