Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
November-2019 Volume 11 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2019 Volume 11 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Rare presentation of small bowel adenocarcinoma with neuroendocrine differentiation in the jejunum: A case report and summary of diagnostic and management options

  • Authors:
    • Emanuela Cimpeanu
    • Wahib Zafar
    • Ioana Circiumaru
    • Ariel Prozumenshikov
    • Shamim Salman
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Richmond University Medical Center, Staten Island, NY 10310, USA, Department of Hematology and Medical Oncology, Westchester Medical Center, Valhalla, NY 10595, USA, Ross University School of Medicine, Miramar, FL 33027, USA, Department of Hematology and Medical Oncology, Richmond University Medical Center, Staten Island, NY 10310, USA
    Copyright: © Cimpeanu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 461-464
    |
    Published online on: September 23, 2019
       https://doi.org/10.3892/mco.2019.1925
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cancer of the small bowel (SB) is rare. The most common SB malignancy is neuroendocrine, followed by adenocarcinoma. SB adenocarcinoma with overlapping neuroendocrine differentiation (NED) is very uncommon. The present case report discusses the case of a young African American female who presented with high‑grade SB perforation and underwent urgent surgical repair. Histology of the tumor revealed jejunal adenocarcinoma with NED. To the best of our knowledge, this type of tumor has not yet been reported in the jejunum. Referring patients that present with insidious and nonspecific abdominal discomfort for imaging studies that are more sensitive to the SB could potentially identify tumors earlier, prevent the development of emergent gastrointestinal complications and offer a chance for cure. An overview of diagnostic tools for SB evaluation was provided.
View Figures

Figure 1

Figure 2

View References

1 

Schottenfeld D, Beebe-Dimmer JL and Vigneau FD: The epidemiology and pathogenesis of neoplasia in the small intestine. Ann Epidemiol. 19:58–69. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Bilimoria KY, Bentrem DJ, Wayne JD, Ko CY, Bennett CL and Talamonti MS: Small bowel cancer in the United States: Changes in epidemiology, treatment, and survival over the last 20 years. Ann Surg. 249:63–71. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Dabaja BS, Suki D, Pro B, Bonnen M and Ajani J: Adenocarcinoma of the small bowel: Presentation, prognostic factors, and outcome of 217 patients. Cancer. 101:518–526. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Li J, Wang Z, Liu N, Hao J and Xu X: Small bowel adenocarcinoma of the jejunum: A case report and literature review. World J Surg Oncol. 14:1772016. View Article : Google Scholar : PubMed/NCBI

5 

Haselkorn T, Whittemore AS and Lilienfeld DE: Incidence of small bowel cancer in the United States and worldwide: Geographic, temporal, and racial differences. Cancer Causes Control. 16:781–787. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Chaiyasate K, Jain AK, Cheung LY, Jacobs MJ and Mittal VK: Prognostic factors in primary adenocarcinoma of the small intestine: 13-year single institution experience. World J Surg Oncol. 6:122008. View Article : Google Scholar : PubMed/NCBI

7 

Young JI, Mongoue-Tchokote S, Wieghard N, Mori M, Vaccaro GM, Sheppard BC and Tsikitis VL: Treatment and survival of small-bowel adenocarcinoma in the United States: A comparison with colon cancer. Dis Colon Rectum. 59:306–315. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Aparicio T, Zaanan A, Svrcek M, Laurent-Puig P, Carrere N, Manfredi S, Locher C and Afchain P: Small bowel adenocarcinoma: Epidemiology, risk factors, diagnosis and treatment. Dig Liver Dis. 46:97–104. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Sun KK, Wu X, Liu G, Qian H and Shen X: Primary adenocarcinoma of the small intestine presenting as superior mesenteric artery syndrome: A case report. Oncol Lett. 11:1903–1906. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Scherübl H, Jensen RT, Cadiot G, Stölzel U and Klöppel G: Neuroendocrine tumors of the small bowels are on the rise: Early aspects and management. World J Gastrointest Endosc. 2:325–334. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Wang KL, Yang Q, Cleary KR, Swisher SG, Correa AM, Komaki R, Ajani JA, Rashid A, Hamilton SR and Wu TT: The significance of neuroendocrine differentiation in adenocarcinoma of the esophagus and esophagogastric junction after preoperative chemoradiation. Cancer. 107:1467–1474. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Fresno MF, Floriano P, Díaz Iglesias JM, Ablanedo P, Pérez del Río MJ, Barneo L and Herrero A: Neuroendocrine carcinoma of the ampullar region with oat-cell histological features and adenocarcinoma. Rev Esp Enferm Dig. 89:60–64. 1997.(In Spanish). PubMed/NCBI

13 

Kim JJ, Kim JY, Hur H, Cho YK and Han SU: Clinicopathologic significance of gastric adenocarcinoma with neuroendocrine features. J Gastric Cancer. 11:195–199. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Matulewicz RS, Fryer JP, Yang XJ, Goyal R and Hairston JC: Renal transplantation in the setting of prior urinary diversion: A case of poorly differentiated adenocarcinoma in an ileal conduit. Urol Case Rep. 3:53–55. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Zeng YJ, Lai W, Liu L, Wu H, Luo XX, Wang J and Chu ZH: Prognostic significance of neuroendocrine differentiation in colorectal adenocarcinoma after radical operation: A meta-analysis. J Gastrointest Surg. 18:968–976. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Rindi G, Arnold R, Bosman FT, Capella C, Klimstra DS, Klöppel G, Komminoth P and Solcia E: Nomenclature and classification of neuroendocrine neoplasms of the digestive systemWHO classification of tumours of the digestive system. 4th. Bosman FT, Carneiro F, Hruban RH and Theise ND: International agency for research on cancer (IARC); Lyon: pp. 13–14. 2010

17 

Overman MJ: Recent advances in the management of adenocarcinoma of the small intestine. Gastrointest Cancer Res. 3:90–96. 2009.PubMed/NCBI

18 

Hakim FA, Alexander JA, Huprich JE, Grover M and Enders FT: CT-enterography may identify small bowel tumors not detected by capsule endoscopy: Eight years experience at Mayo Clinic Rochester. Dig Dis Sci. 56:2914–2919. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Pilleul F, Penigaud M, Milot L, Saurin JC, Chayvialle JA and Valette PJ: Possible small-bowel neoplasms: Contrast-enhanced and water-enhanced multidetector CT enteroclysis. Radiology. 241:796–801. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Ilangovan R, Burling D, George A, Gupta A, Marshall M and Taylor SA: CT enterography: Review of technique and practical tips. Br J Radiol. 85:876–886. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Lewis BS, Eisen GM and Friedman S: A pooled analysis to evaluate results of capsule endoscopy trials. Endoscopy. 37:960–965. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Rondonotti E, Pennazio M, Toth E, Menchen P, Riccioni ME, De Palma GD, Scotto F, De Looze D, Pachofsky T, Tacheci I, et al: Small-bowel neoplasms in patients undergoing video capsule endoscopy: A multicenter European study. Endoscopy. 40:488–495. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Sulbaran M, de Moura E, Bernardo W, Morais C, Oliveira J, Bustamante-Lopez L, Sakai P, Mönkemüller K and Safatle-Ribeiro A: Overtube-assisted enteroscopy and capsule endoscopy for the diagnosis of small-bowel polyps and tumors: A systematic review and meta-analysis. Endosc Int Open. 4:E151–E163. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Hervieu V and Scoazec JY: Mixed endocrine tumors. Ann Pathol. 25:511–528. 2005.(In French). View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cimpeanu E, Zafar W, Circiumaru I, Prozumenshikov A and Salman S: Rare presentation of small bowel adenocarcinoma with neuroendocrine differentiation in the jejunum: A case report and summary of diagnostic and management options. Mol Clin Oncol 11: 461-464, 2019.
APA
Cimpeanu, E., Zafar, W., Circiumaru, I., Prozumenshikov, A., & Salman, S. (2019). Rare presentation of small bowel adenocarcinoma with neuroendocrine differentiation in the jejunum: A case report and summary of diagnostic and management options. Molecular and Clinical Oncology, 11, 461-464. https://doi.org/10.3892/mco.2019.1925
MLA
Cimpeanu, E., Zafar, W., Circiumaru, I., Prozumenshikov, A., Salman, S."Rare presentation of small bowel adenocarcinoma with neuroendocrine differentiation in the jejunum: A case report and summary of diagnostic and management options". Molecular and Clinical Oncology 11.5 (2019): 461-464.
Chicago
Cimpeanu, E., Zafar, W., Circiumaru, I., Prozumenshikov, A., Salman, S."Rare presentation of small bowel adenocarcinoma with neuroendocrine differentiation in the jejunum: A case report and summary of diagnostic and management options". Molecular and Clinical Oncology 11, no. 5 (2019): 461-464. https://doi.org/10.3892/mco.2019.1925
Copy and paste a formatted citation
x
Spandidos Publications style
Cimpeanu E, Zafar W, Circiumaru I, Prozumenshikov A and Salman S: Rare presentation of small bowel adenocarcinoma with neuroendocrine differentiation in the jejunum: A case report and summary of diagnostic and management options. Mol Clin Oncol 11: 461-464, 2019.
APA
Cimpeanu, E., Zafar, W., Circiumaru, I., Prozumenshikov, A., & Salman, S. (2019). Rare presentation of small bowel adenocarcinoma with neuroendocrine differentiation in the jejunum: A case report and summary of diagnostic and management options. Molecular and Clinical Oncology, 11, 461-464. https://doi.org/10.3892/mco.2019.1925
MLA
Cimpeanu, E., Zafar, W., Circiumaru, I., Prozumenshikov, A., Salman, S."Rare presentation of small bowel adenocarcinoma with neuroendocrine differentiation in the jejunum: A case report and summary of diagnostic and management options". Molecular and Clinical Oncology 11.5 (2019): 461-464.
Chicago
Cimpeanu, E., Zafar, W., Circiumaru, I., Prozumenshikov, A., Salman, S."Rare presentation of small bowel adenocarcinoma with neuroendocrine differentiation in the jejunum: A case report and summary of diagnostic and management options". Molecular and Clinical Oncology 11, no. 5 (2019): 461-464. https://doi.org/10.3892/mco.2019.1925
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team