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Case Report Open Access

Chemoradiotherapy with FOLFOX for esophageal squamous cell cancer with synchronous rectal cancer: Four case reports and a literature review

  • Authors:
    • Takako Yoshii
    • Hiroki Hara
    • Masako Asayama
    • Yosuke Kumekawa
    • Shoichi Miyazawa
    • Naoki Takahashi
    • Tomohiro Matsushima
    • Satoshi Shimizu
    • Yoshihiro Saito
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Saitama Cancer Center, Saitama 362‑0806, Japan, Department of Radiotherapy, Saitama Cancer Center, Saitama 362‑0806, Japan
    Copyright: © Yoshii et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 23-30
    |
    Published online on: October 31, 2019
       https://doi.org/10.3892/mco.2019.1945
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Abstract

Chemoradiotherapy (CRT) is a valuable treatment option for localized esophageal cancer. Conventional baseline chemotherapy for this type of cancer includes cisplatin and fluorouracil. Recently, CRT with leucovorin‑ fluorouracil‑oxaliplatin (FOLFOX) has become popular due to its convenience and lower toxicity. In Japan, the use of oxaliplatin for esophageal cancer is not yet approved, so experience with this treatment is limited to cases with colorectal cancer. As such patients are not usually included in clinical trials, little is known on the efficacy and safety of this treatment for this patient subpopulation, and treatment generalization in Japan is not allowed. We herein share our experience with CRT and FOLFOX for cases with esophageal cancer and synchronous rectal cancer at our institution. The clinical data of 4 patients who were treated for esophageal cancer with CRT/FOLFOX at our hospital between 2007 and 2016, who also had synchronous rectal cancer, were retrieved and analyzed. All the patients were male and had esophageal squamous cell cancer and synchronous rectal cancer. The median patient age was 68 years (range, 65‑77 years). One patient received neoadjuvant CRT followed by surgery, and the other 3 patients received definitive CRT for esophageal cancer. FOLFOX was administered biweekly during radiotherapy (41.4‑60 Gy). All 4 patients completed the treatment schedule and responded to CRT. No patients experienced progression of rectal cancer during treatment. Notably, 1 patient also achieved a complete response (CR) of rectal cancer after CRT for esophageal cancer. Moreover, 2 patients without dysphagia were treated as outpatients and achieved a CR. Encephalopathy was the only reported grade 3 adverse event. Although the present study included a limited number of cases, the findings suggest that CRT with FOLFOX may be a valuable option for the treatment of patients with esophageal squamous cell cancer and synchronous rectal cancer.
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1 

Global Burden of Disease Cancer Collaboration, ; Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, Allen C, Hansen G, Woodbrook R, et al: The global burden of cancer 2013. JAMA Oncol. 1:505–527. 2015. View Article : Google Scholar : PubMed/NCBI

2 

National Comprehensive Cancer Network, . Clinical practice oncology: Esophageal and esophagogastric junction cancers (version 2. 2017).

3 

Stahl M, Mariette C, Haustermans K, Cervantes A and Arnold D; ESMO Guidelines Working Group, : Oesophageal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 24 (Suppl 6):vi51–vi56. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Cooper JS, Guo MD, Herskovic A, Macdonald JS, Martenson JA Jr, Al-Sarraf M, Byhardt R, Russell AH, Beitler JJ, Spencer S, et al: Chemoradiotherapy of locally advanced esophageal cancer: Long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation therapy oncology group. JAMA. 281:1623–1627. 1999. View Article : Google Scholar : PubMed/NCBI

5 

Minsky BD, Pajak TF, Ginsberg RJ, Pisansky TM, Martenson J, Komaki R, Okawara G, Rosenthal SA and Kelsen DP: INT 0123 (radiation therapy oncology group 94-05) phase III trial of combined-modality therapy for esophageal cancer: High-dose versus standard-dose radiation therapy. J Clin Oncol. 20:1167–1174. 2002. View Article : Google Scholar : PubMed/NCBI

6 

al-Sarraf M, Martz K, Herskovic A, Leichman L, Brindle JS, Vaitkevicius VK, Cooper J, Byhardt R, Davis L and Emami B: Progress report of combined chemoradiotherapy versus radiotherapy alone in patients with esophageal cancer: An intergroup study. J Clin Oncol. 15:277–284. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Conroy T, Yataghene Y, Etienne PL, Michel P, Senellart H, Raoul JL, Mineur L, Rives M, Mirabel X, Lamezec B, et al: Phase II randomised trial of chemoradiotherapy with FOLFOX4 or cisplatin plus fluorouracil in oesophageal cancer. Br J Cancer. 103:1349–1355. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Conroy T, Galais MP, Raoul JL, Bouche O, Gourgou-Bourgade S, Douillard JY, Etienne PL, Boige V, Martel-Lafay I, Michel P, et al: Definitive chemoradiotherapy with FOLFOX versus fluorouracil and cisplatin in patients with oesophageal cancer (PRODIGE5/ACCORD17): Final results of a randomised, phase 2/3 trial. Lancet Oncol. 15:305–314. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Messager M, Mirabel X, Tresch E, Paumier A, Vendrely V, Dahan L, Glehen O, Vasseur F, Lacornerie T, Piessen G, et al: Preoperative chemoradiation with paclitaxel-carboplatin or with fluorouracil-oxaliplatin-folinic acid (FOLFOX) for resectable esophageal and junctional cancer: The PROTECT-1402, randomized phase 2 trial. BMC Cancer. 16:3182016. View Article : Google Scholar : PubMed/NCBI

10 

Shinoda M, Ando N, Kato K, Ishikura S, Kato H, Tsubosa Y, Minashi K, Okabe H, Kimura Y, Kawano T, et al: Randomized study of low-dose versus standard-dose chemoradiotherapy for unresectable esophageal squamous cell carcinoma (JCOG0303). Cancer Sci. 106:407–412. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Kato K, Muro K, Minashi K, Ohtsu A, Ishikura S, Boku N, Takiuchi H, Komatsu Y, Miyata Y, Fukuda H, et al: Phase II study of chemoradiotherapy with 5-fluorouracil and cisplatin for stage II–III esophageal squamous cell carcinoma: JCOG trial (JCOG 9906). Int J Radiat Oncol Biol Phys. 81:684–690. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Kato H, Sato A, Fukuda H, Kagami Y, Udagawa H, Togo A, Ando N, Tanaka O, Shinoda M, Yamana H and Ishikura S: A phase II trial of chemoradiotherapy for stage I esophageal squamous cell carcinoma: Japan clinical oncology group study (JCOG9708). Jpn J Clin Oncol. 39:638–643. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Japan Esophageal Society, . Japanase classification of esophageal cancer, 11th edition: Part II and III. Esophagus. 14:37–65. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Eisenhauera EA, Therasseb P, Bogaertsc J, Schwartzd H, Sargente D, Ford R, Dancey J, Gwyther S, Mooney M, Rubinstein L, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

15 

National Institutes of Health Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0US Department of Health and Human Services. National Institutes of Health, National Cancer Center, National Cancer Center; Washington DC: 2009

16 

de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, Boni C, Cortes-Funes H, Cervantes A, Freyer G, et al: Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol. 18:2938–2947. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Andre T, Boni C, Mounedji-Boudiaf L, Navarro M, Tabernero J, Hickish T, Topham C, Zaninelli M, Clingan P, Bridgewater J, et al: Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med. 350:2343–2351. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Khushalani NI, Leichman CG, Proulx G, Nava H, Bodnar L, Klippenstein D, Litwin A, Smith J, Nava E, Pendyala L, et al: Oxaliplatin in combination with protracted-infusion fluorouracil and radiation: Report of a clinical trial for patients with esophageal cancer. J Clin Oncol. 20:2844–2850. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Chiarion-Sileni V, Innocente R, Cavina R, Ruol A, Corti L, Pigozzo J, Del Bianco P, Fumagalli U, Santoro A and Ancona E: Multi-center phase II trial of chemo-radiotherapy with 5-fluorouracil, leucovorin and oxaliplatin in locally advanced esophageal cancer. Cancer Chemother Pharmacol. 63:1111–1119. 2009. View Article : Google Scholar : PubMed/NCBI

20 

O'Connor BM, Chadha MK, Pande A, Lombardo JC, Nwogu CE, Nava HR, Yang G and Javle MM: Concurrent oxaliplatin, 5-fluorouracil, and radiotherapy in the treatment of locally advanced esophageal carcinoma. Cancer J. 13:119–124. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, et al: Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 355:11–20. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Bang YJ, Kim YW, Yang HK, Chung HC, Park YK, Lee KH, Lee KW, Kim YH, Noh SI, Cho JY, et al: Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): A phase 3 open-label, randomised controlled trial. Lancet. 379:315–321. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Yamada Y, Higuchi K, Nishikawa K, Gotoh M, Fuse N, Sugimoto N, Nishina T, Amagai K, Chin K, Niwa Y, et al: Phase III study comparing oxaliplatin plus S-1 with cisplatin plus S-1 in chemotherapy-naive patients with advanced gastric cancer. Ann Oncol. 26:141–148. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Masuishi T, Kadowaki S, Kondo M, Komori A, Sugiyama K, Mitani S, Honda K, Narita Y, Taniguchi H, Ura T, et al: FOLFOX as first-line therapy for gastric cancer with severe peritoneal metastasis. Anticancer Res. 37:7037–7042. 2017.PubMed/NCBI

25 

Watanabe Y, Tsutsui M, Takeda S, Yoshino S and Oka M: A case of esophageal cancer associated with colon cancer successfully treated with combination chemotherapy of FOLFOX and concurrent radiotherapy. Gan To Kagaku Ryoho. 36:2439–2441. 2009.(In Japanese). PubMed/NCBI

26 

Allegra CJ, Yothers G, O'Connell MJ, Sharif S, Colangelo LH, Lopa SH, Petrelli NJ, Goldberg RM, Atkins JN, Seay TE, et al: Initial safety report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer. J Clin Oncol. 27:3385–3390. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Mitani S, Kadowaki S, Kato K, Masuishi T and Muro K: Combination of oxaliplatin and 5-fluorouracil/leucovorin for advanced esophageal squamous cell carcinoma refractory or intolerant to standard therapies. Case Rep Oncol. 12:304–310. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yoshii T, Hara H, Asayama M, Kumekawa Y, Miyazawa S, Takahashi N, Matsushima T, Shimizu S and Saito Y: Chemoradiotherapy with FOLFOX for esophageal squamous cell cancer with synchronous rectal cancer: Four case reports and a literature review. Mol Clin Oncol 12: 23-30, 2020.
APA
Yoshii, T., Hara, H., Asayama, M., Kumekawa, Y., Miyazawa, S., Takahashi, N. ... Saito, Y. (2020). Chemoradiotherapy with FOLFOX for esophageal squamous cell cancer with synchronous rectal cancer: Four case reports and a literature review. Molecular and Clinical Oncology, 12, 23-30. https://doi.org/10.3892/mco.2019.1945
MLA
Yoshii, T., Hara, H., Asayama, M., Kumekawa, Y., Miyazawa, S., Takahashi, N., Matsushima, T., Shimizu, S., Saito, Y."Chemoradiotherapy with FOLFOX for esophageal squamous cell cancer with synchronous rectal cancer: Four case reports and a literature review". Molecular and Clinical Oncology 12.1 (2020): 23-30.
Chicago
Yoshii, T., Hara, H., Asayama, M., Kumekawa, Y., Miyazawa, S., Takahashi, N., Matsushima, T., Shimizu, S., Saito, Y."Chemoradiotherapy with FOLFOX for esophageal squamous cell cancer with synchronous rectal cancer: Four case reports and a literature review". Molecular and Clinical Oncology 12, no. 1 (2020): 23-30. https://doi.org/10.3892/mco.2019.1945
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshii T, Hara H, Asayama M, Kumekawa Y, Miyazawa S, Takahashi N, Matsushima T, Shimizu S and Saito Y: Chemoradiotherapy with FOLFOX for esophageal squamous cell cancer with synchronous rectal cancer: Four case reports and a literature review. Mol Clin Oncol 12: 23-30, 2020.
APA
Yoshii, T., Hara, H., Asayama, M., Kumekawa, Y., Miyazawa, S., Takahashi, N. ... Saito, Y. (2020). Chemoradiotherapy with FOLFOX for esophageal squamous cell cancer with synchronous rectal cancer: Four case reports and a literature review. Molecular and Clinical Oncology, 12, 23-30. https://doi.org/10.3892/mco.2019.1945
MLA
Yoshii, T., Hara, H., Asayama, M., Kumekawa, Y., Miyazawa, S., Takahashi, N., Matsushima, T., Shimizu, S., Saito, Y."Chemoradiotherapy with FOLFOX for esophageal squamous cell cancer with synchronous rectal cancer: Four case reports and a literature review". Molecular and Clinical Oncology 12.1 (2020): 23-30.
Chicago
Yoshii, T., Hara, H., Asayama, M., Kumekawa, Y., Miyazawa, S., Takahashi, N., Matsushima, T., Shimizu, S., Saito, Y."Chemoradiotherapy with FOLFOX for esophageal squamous cell cancer with synchronous rectal cancer: Four case reports and a literature review". Molecular and Clinical Oncology 12, no. 1 (2020): 23-30. https://doi.org/10.3892/mco.2019.1945
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