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Article

Clinicopathological features of small‑sized peripheral squamous cell lung cancer

  • Authors:
    • Takayuki Kosaka
    • Kimihiro Shimizu
    • Seshiru Nakazawa
    • Misaki Iijima
    • Yoichi Ohtaki
    • Yoko Azuma
    • Kai Obayashi
    • Toshiteru Nagashima
    • Toshiki Yajima
    • Akira Mogi
    • Hiroyuki Kuwano
    • Ken Shirabe
  • View Affiliations / Copyright

    Affiliations: Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371‑8511, Japan
  • Pages: 69-74
    |
    Published online on: November 18, 2019
       https://doi.org/10.3892/mco.2019.1951
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Abstract

Recent advances in imaging technology have enhanced the detection rate of small‑sized peripheral lung cancers. The present study aimed to identify the clinicopathological differences between patients with small‑sized peripheral squamous cell carcinoma (SCC) and adenocarcinoma (ADC). Patients with lung cancer who underwent radical surgical resection at Gunma University Hospital between July 2007 and October 2012 were retrospectively analyzed. Patients who exhibited small‑sized peripheral tumors (pathological size, ≤2 cm) located within the outer‑third of the lung field on preoperative computed tomography were enrolled in the present study. A total of 26 patients were diagnosed with SCC and 214 with ADC. The results revealed that patients with SCC exhibited higher rates of pleural invasion, vascular invasion and lymphatic invasion compared with ADC patients. Additionally, the rate of postoperative recurrence was higher in patients with SCC compared with ADC patients. Patients with ADC were subsequently into two groups: Solid ADCs (sADC) and non‑solid ADCs (nsADC), which included pure ground glass nodules and part‑solid ADCs. The results revealed that the incidence of pleural invasion, vascular invasion and lymphatic invasion, and the rate of postoperative recurrence in patients with sADCs were similar to those with SCC, but were also significantly higher when compared with nsADC patients. The present study concluded that patients with SCC and sADC may not be suitable candidates for sublobar resection, despite exhibiting small tumors that are located in the peripheral lung.
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Copy and paste a formatted citation
Spandidos Publications style
Kosaka T, Shimizu K, Nakazawa S, Iijima M, Ohtaki Y, Azuma Y, Obayashi K, Nagashima T, Yajima T, Mogi A, Mogi A, et al: Clinicopathological features of small‑sized peripheral squamous cell lung cancer. Mol Clin Oncol 12: 69-74, 2020.
APA
Kosaka, T., Shimizu, K., Nakazawa, S., Iijima, M., Ohtaki, Y., Azuma, Y. ... Shirabe, K. (2020). Clinicopathological features of small‑sized peripheral squamous cell lung cancer. Molecular and Clinical Oncology, 12, 69-74. https://doi.org/10.3892/mco.2019.1951
MLA
Kosaka, T., Shimizu, K., Nakazawa, S., Iijima, M., Ohtaki, Y., Azuma, Y., Obayashi, K., Nagashima, T., Yajima, T., Mogi, A., Kuwano, H., Shirabe, K."Clinicopathological features of small‑sized peripheral squamous cell lung cancer". Molecular and Clinical Oncology 12.1 (2020): 69-74.
Chicago
Kosaka, T., Shimizu, K., Nakazawa, S., Iijima, M., Ohtaki, Y., Azuma, Y., Obayashi, K., Nagashima, T., Yajima, T., Mogi, A., Kuwano, H., Shirabe, K."Clinicopathological features of small‑sized peripheral squamous cell lung cancer". Molecular and Clinical Oncology 12, no. 1 (2020): 69-74. https://doi.org/10.3892/mco.2019.1951
Copy and paste a formatted citation
x
Spandidos Publications style
Kosaka T, Shimizu K, Nakazawa S, Iijima M, Ohtaki Y, Azuma Y, Obayashi K, Nagashima T, Yajima T, Mogi A, Mogi A, et al: Clinicopathological features of small‑sized peripheral squamous cell lung cancer. Mol Clin Oncol 12: 69-74, 2020.
APA
Kosaka, T., Shimizu, K., Nakazawa, S., Iijima, M., Ohtaki, Y., Azuma, Y. ... Shirabe, K. (2020). Clinicopathological features of small‑sized peripheral squamous cell lung cancer. Molecular and Clinical Oncology, 12, 69-74. https://doi.org/10.3892/mco.2019.1951
MLA
Kosaka, T., Shimizu, K., Nakazawa, S., Iijima, M., Ohtaki, Y., Azuma, Y., Obayashi, K., Nagashima, T., Yajima, T., Mogi, A., Kuwano, H., Shirabe, K."Clinicopathological features of small‑sized peripheral squamous cell lung cancer". Molecular and Clinical Oncology 12.1 (2020): 69-74.
Chicago
Kosaka, T., Shimizu, K., Nakazawa, S., Iijima, M., Ohtaki, Y., Azuma, Y., Obayashi, K., Nagashima, T., Yajima, T., Mogi, A., Kuwano, H., Shirabe, K."Clinicopathological features of small‑sized peripheral squamous cell lung cancer". Molecular and Clinical Oncology 12, no. 1 (2020): 69-74. https://doi.org/10.3892/mco.2019.1951
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