Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
February-2020 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2020 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Cathepsin S as a target in gastric cancer (Review)

  • Authors:
    • Adriano Carneiro da Costa
    • Fernando Santa‑Cruz
    • Luiz Alberto Reis Mattos
    • Maria Améllia Rêgo Aquino
    • Camila Ramos Martins
    • Álvaro Antônio Bandeira Ferraz
    • José Luiz Figueiredo
  • View Affiliations / Copyright

    Affiliations: Unidade de Oncologia, Hospital das Clínicas da Universidade Federal de Pernambuco, Recife, PE 50670‑901, Brazil, Centro de Ciências Médicas, Universidade Federal de Pernambuco, Recife, PE 50670‑901, Brazil, Curso de Medicina, Centro Universitário de João Pessoa, Recife, PE 50670‑901, Brazil, Departamento de Cirurgia, Universidade Federal de Pernambuco, Recife, PE 50670‑901, Brazil
    Copyright: © da Costa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 99-103
    |
    Published online on: December 3, 2019
       https://doi.org/10.3892/mco.2019.1958
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cathepsin S (Cat S) is a protein expressed in some epithelial cells, which appears to be associated with cancer metastasis and recurrence. The abnormal expression of Cat S has been reported to be associated with the progression of certain types of gastrointestinal neoplasms, including gastric cancer (GC). There is a need to identify novel biomarkers and therapeutic targets associated with the growth, invasion and migration of GC cells, in order to develop non‑invasive diagnostic and prognostic procedures and design new therapeutic approaches. The aim of the present study was to assess the association between Cat S and oncogenic processes implicated in the development of GC, focusing on the diagnostic and therapeutic potential of this molecule in GC. A search was conducted through the PubMed and Cochrane Central Register of Controlled Trials electronic databases for relevant literature published between 2003 and 2018, using the mesh terms ‘cathepsin S’ and ‘cancer’ and ‘gastric cancer’.
View Figures
View References

1 

López-Otín C and Matrisian LM: Emerging roles of proteases in tumor suppression. Nat Rev Cancer. 7:800–808. 2007.PubMed/NCBI View Article : Google Scholar

2 

Rawlings ND, Barrett AJ and Bateman A: MEROPS: The database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Res. 40 (Database Issue):D343–D350. 2012.PubMed/NCBI View Article : Google Scholar

3 

Tan GJ, Peng ZK, Lu JP and Tang FQ: Cathepsins mediate tumor metastasis. World J Biol Chem. 4:91–101. 2013.PubMed/NCBI View Article : Google Scholar

4 

Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D and Joyce JA: Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev. 20:543–556. 2006.PubMed/NCBI View Article : Google Scholar

5 

Turk B, Turk D and Turk V: Protease signalling: The cutting edge. EMBO J. 31:1630–1643. 2012.PubMed/NCBI View Article : Google Scholar

6 

Repnik U, Starr AE, Overall CM and Turk B: Cysteine cathepsins activate ELR chemokines and inactivate non-ELR chemokines. J Biol Chem. 290:13800–13811. 2015.PubMed/NCBI View Article : Google Scholar

7 

Wilkinson RD, Magorrian SM, Williams R, Young A, Small DM, Scott CJ and Burden RE: CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74 dependent manner. Oncotarget. 6:29725–29739. 2015.PubMed/NCBI View Article : Google Scholar

8 

Joyce JA, Baruch A, Chehade K, Meyer-Morse N, Giraudo E, Tsai FY, Greenbaum DC, Hager JH, Bogyo M and Hanahan D: Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell. 5:443–453. 2004.PubMed/NCBI View Article : Google Scholar

9 

National Comprehensive Cancer Network: Gastric cancer. NCCN clinical practice guidelines in oncology. Version 2.2018, May 22, 2018.

10 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005.PubMed/NCBI View Article : Google Scholar

11 

Crew KD and Neugut AI: Epidemiology of gastric cancer. World J Gastroenterol. 12:354–362. 2006.PubMed/NCBI View Article : Google Scholar

12 

Mohanty S and Panda KS: Gastric cancer in young patients under the age of 35 years: A hospital-based study. Int Surg J. 3:1933–1936. 2016. View Article : Google Scholar

13 

Egger ME, Ikoma N and Badgwell BD: Primary gastric malignancies. In: Feig BW Ching CD (eds). The MD Anderson Surgical Oncology Handbook. 6th edition. Philadelphia. Worters Kluwer. pp379–431. 2019.

14 

Ahn HJ and Lee DS: Helicobacter pylori in gastric carcinogenesis. World J Gastrointest Oncol. 7:455–465. 2015.PubMed/NCBI View Article : Google Scholar

15 

Hartgrink HH, Jansen EP, van Grieken NC and van de Velde CJ: Gastric cancer. Lancet. 374:477–490. 2009.PubMed/NCBI View Article : Google Scholar

16 

Bae JM and Kim EH: Helicobacter pylori infection and risk of gastric cancer in Korea: A quantitative systematic review. J Prev Med Public Health. 49:197–204. 2016.PubMed/NCBI View Article : Google Scholar

17 

Amedei A, Munari F, Bella CD, Niccolai E, Benagiano M, Bencini L, Cianchi F, Farsi M, Emmi G, Zanotti G, et al: Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma. Intern Emerg Med. 9:303–309. 2014.PubMed/NCBI View Article : Google Scholar

18 

Carneiro F, Machado JC, David L, Reis C, Nogueira AM and Sobrinho-Simões M: Current thoughts on the histopathogenesis of gastric cancer. Eur J Cancer Prev. 10:101–102. 2001.PubMed/NCBI View Article : Google Scholar

19 

Scartozzi M, Galizia E, Freddari F, Berardi R, Cellerino R and Cascinu S: Molecular biology of sporadic gastric cancer: Prognostic indicators and novel therapeutic approaches. Cancer Treat Rev. 30:451–459. 2004.PubMed/NCBI View Article : Google Scholar

20 

Lynch HT, Grady W, Suriano G and Huntsman D: Gastric cancer: New genetic developments. J Surg Oncol. 90:114–133. 2005.PubMed/NCBI View Article : Google Scholar

21 

Kono K, Takahashi A, Ichihara F, Sugai H, Fujii H and Matsumoto Y: Impaired antibody-dependent cellular cytotoxicity mediated by herceptin in patients with gastric cancer. Cancer Res. 62:5813–5817. 2002.PubMed/NCBI

22 

Doi T, Koizumi W, Siena S, Cascinu S, Ohtsu A and Michael M: Efficacy, tolerability and pharmacokinetics of gefinitib (ZD1839) in pretreated patients with metastatic gastric cancer. Proc Am Soc Clin Oncol. 22(Abstr 1036)2003.

23 

Shi GP, Sukhova GK, Kuzuya M, Ye Q, Du J, Zhang Y, Pan JH, Lu ML, Cheng XW, Iguchi A, et al: Deficiency of the cysteine protease cathepsin S impairs microvessel growth. Circ Res. 92:493–500. 2003.PubMed/NCBI View Article : Google Scholar

24 

Vázquez R, Astorgues-Xerri L, Bekradda M, Gormley J, Buick R, Kerr P, Cvitkovic E, Raymond E, D'Incalci M, Frapolli R and Riveiro ME: Fsn0503h antibody-mediated blockade of cathepsin S as a potential therapeutic strategy for the treatment of solid tumors. Biochimie. 108:101–107. 2015.PubMed/NCBI View Article : Google Scholar

25 

Burden RE, Gormley JA, Jaquin TJ, Small DM, Quinn DJ, Hegarty SM, Ward C, Walker B, Johnston JA, Olwill SA and Scott CJ: Antibody-mediated inhibition of cathepsin S blocks colorectal tumor invasion and angiogenesis. Clin Cancer Res. 15:6042–6051. 2009.PubMed/NCBI View Article : Google Scholar

26 

Burden RE, Gormley JA, Kuehn D, Ward C, Kwok HF, Gazdoiu M, McClurg A, Jaquin TJ, Johnston JA, Scott CJ and Olwill SA: Inhibition of cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas. Biochemie. 94:487–493. 2012.PubMed/NCBI View Article : Google Scholar

27 

Zhang L, Wang H and Xu J: Cathepsin S as a cancer target. Neoplasma. 62:16–26. 2015.PubMed/NCBI View Article : Google Scholar

28 

Sevenich L, Bowman RL, Mason SD, Quail DF, Rapaport F, Elie BT, Brogi E, Brastianos PK, Hahn WC, Holsinger LJ, et al: Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S. Nat Cell Biol. 16:876–888. 2014.PubMed/NCBI View Article : Google Scholar

29 

Huang CC, Chen KL, Cheung CHA and Chang JY: Autophagy induced by cathepsin S inhibition induces early ROS production, oxidative DNA damage, and cell death via xanthine oxidase. Free Radic Biol Med. 65:1473–1486. 2013.PubMed/NCBI View Article : Google Scholar

30 

Small DM, Burden RE, Jaworski J, Hegarty SM, Spence S, Burrows JF, McFarlane C, Kissenpfennig A, McCarthy HO, Johnston JA, et al: Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization. Int J Cancer. 133:2102–2112. 2013.PubMed/NCBI View Article : Google Scholar

31 

Liu WL, Liu D, Cheng K, Liu YJ, Xing S, Chi PD, Liu XH, Xue N, Lai YZ, Guo L and Zhang G: Evaluating the diagnostic and prognostic value of circulating cathepsin S in gastric cancer. Oncotarget. 7:28124–28138. 2016.PubMed/NCBI View Article : Google Scholar

32 

Kwok HF, Buick RJ, Kuehn D, Gormley JA, Doherty D, Jaquin TJ, McClurg A, Ward C, Byrne T, Jaworski J, et al: Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity. Mol Cancer. 10(147)2011.PubMed/NCBI View Article : Google Scholar

33 

Yang Y, Lim SK, Choong LY, Lee H, Chen Y, Chong PK, Ashktorab H, Wang TT, Salto-Tellez M, Yeoh KG and Lim YP: Cathepsin S mediates gastric cancer cell migration and invasion via a putative network of metastasis-associated proteins. J Proteome Res. 9:4767–4778. 2010.PubMed/NCBI View Article : Google Scholar

34 

Turk V, Turk B and Turk D: Lysosomal cysteine proteases: Facts and opportunities. EMBO J. 20:4629–4633. 2001.PubMed/NCBI View Article : Google Scholar

35 

Jordans S, Jenko-Kokalj S, Kuhl NM, Tedelind S, Sendt W, Bromme D, Turk D and Brix K: Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions. BMC Biochem. 10(23)2009.PubMed/NCBI View Article : Google Scholar

36 

Turk V, Stoka V, Vasiljeva O, Renko M, Sun T, Turk B and Turk D: Cysteine cathepsins: From structure, function and regulation to new frontiers. Biochim Biophys Acta. 1824:68–88. 2012.PubMed/NCBI View Article : Google Scholar

37 

Wang B, Sun J, Kitamoto S, Yang M, Grubb A, Chapman HA, Kalluri R and Shi GP: Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors. J Biol Chem. 281:6020–6029. 2006.PubMed/NCBI View Article : Google Scholar

38 

Lee TK, Cheung VC, Lu P, Lau EY, Ma S, Tang KH, Tong M, Lo J and Ng IO: Blockade of CD47-mediated cathepsin S/protease-activated receptor 2 signaling provides a therapeutic target for hepatocellular carcinoma. Hepatology. 60:179–191. 2014.PubMed/NCBI View Article : Google Scholar

39 

Wang X, Xiong L, Yu G, Li D, Peng T, Luo D and Xu J: Cathepsin S silencing induces apoptosis of human hepatocellular carcinoma cells. Am J Transl Res. 19:100–110. 2015.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
da Costa AC, Santa‑Cruz F, Mattos LA, Aquino MA, Martins CR, Ferraz ÁA and Figueiredo JL: Cathepsin S as a target in gastric cancer (Review). Mol Clin Oncol 12: 99-103, 2020.
APA
da Costa, A.C., Santa‑Cruz, F., Mattos, L.A., Aquino, M.A., Martins, C.R., Ferraz, Á.A., & Figueiredo, J.L. (2020). Cathepsin S as a target in gastric cancer (Review). Molecular and Clinical Oncology, 12, 99-103. https://doi.org/10.3892/mco.2019.1958
MLA
da Costa, A. C., Santa‑Cruz, F., Mattos, L. A., Aquino, M. A., Martins, C. R., Ferraz, Á. A., Figueiredo, J. L."Cathepsin S as a target in gastric cancer (Review)". Molecular and Clinical Oncology 12.2 (2020): 99-103.
Chicago
da Costa, A. C., Santa‑Cruz, F., Mattos, L. A., Aquino, M. A., Martins, C. R., Ferraz, Á. A., Figueiredo, J. L."Cathepsin S as a target in gastric cancer (Review)". Molecular and Clinical Oncology 12, no. 2 (2020): 99-103. https://doi.org/10.3892/mco.2019.1958
Copy and paste a formatted citation
x
Spandidos Publications style
da Costa AC, Santa‑Cruz F, Mattos LA, Aquino MA, Martins CR, Ferraz ÁA and Figueiredo JL: Cathepsin S as a target in gastric cancer (Review). Mol Clin Oncol 12: 99-103, 2020.
APA
da Costa, A.C., Santa‑Cruz, F., Mattos, L.A., Aquino, M.A., Martins, C.R., Ferraz, Á.A., & Figueiredo, J.L. (2020). Cathepsin S as a target in gastric cancer (Review). Molecular and Clinical Oncology, 12, 99-103. https://doi.org/10.3892/mco.2019.1958
MLA
da Costa, A. C., Santa‑Cruz, F., Mattos, L. A., Aquino, M. A., Martins, C. R., Ferraz, Á. A., Figueiredo, J. L."Cathepsin S as a target in gastric cancer (Review)". Molecular and Clinical Oncology 12.2 (2020): 99-103.
Chicago
da Costa, A. C., Santa‑Cruz, F., Mattos, L. A., Aquino, M. A., Martins, C. R., Ferraz, Á. A., Figueiredo, J. L."Cathepsin S as a target in gastric cancer (Review)". Molecular and Clinical Oncology 12, no. 2 (2020): 99-103. https://doi.org/10.3892/mco.2019.1958
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team