Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
February-2020 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2020 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Efficacy of nerve‑sparing radical hysterectomy vs. conventional radical hysterectomy in early‑stage cervical cancer: A systematic review and meta‑analysis

  • Authors:
    • Seung Hyun Lee
    • Jong Woon Bae
    • Myoungseok Han
    • Yeon Jean Cho
    • Jung‑Woo Park
    • So Ra Oh
    • Su Jin Kim
    • Sun Yi Choe
    • Jeong Hye Yun
    • Yongmin Lee
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, College of Medicine, Dong‑A University, Seo‑gu, Busan 49201, Republic of Korea
    Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 160-168
    |
    Published online on: December 4, 2019
       https://doi.org/10.3892/mco.2019.1959
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to compare the oncological outcome of nerve‑sparing radical hysterectomy (NSRH) and conventional radical hysterectomy (CRH) for early‑stage cervical cancer using a meta‑analysis. A systematic review and meta‑analysis was conducted, including 4 randomized controlled trials (RCT), 8 case‑control and 11 comparative cohort studies comparing the morbidity, pelvic dysfunctions and oncological outcome between the two surgical methods. A total of 23 studies were included in this meta‑analysis. The studies reported data of patients affected by cervical cancer; were written in English; included ≥20 patients; and reported data of patients with a comparison of clinical outcomes between NSRH and CRH. Data were extracted and risk of bias was assessed by four independent reviewers. A total of 1,796 patients were included: 884 patients (49.2%) undergoing NSRH and 912 (50.8%) undergoing CRH. The meta‑analyses were conducted using Review Manager version 5.3 software, which is designed for conducting Cochrane reviews. As regards perioperative parameters, NSRH was found to be associated with a lower intraoperative blood loss and a shorter length of hospital stay in comparison with CRH. Patients undergoing NSRH experienced lower incidence of urinary, colorectal and sexual dysfunction compared with patients undergoing CRH. However, the resected parametrial width was favorable in patients with CRH, suggesting that NSRH was inferior to CRH in terms of radicality. The 5‑year disease‑free and overall survival rates were similar between the two groups. In this systematic review and meta‑analysis, the collected data to date demonstrated that the nerve‑sparing approach guarantees minimized surgical‑related pelvic dysfunction, with similar oncological outcomes as CRH. However, further RCTs should be conducted to confirm the superiority and safety of NSRH.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017.PubMed/NCBI View Article : Google Scholar

2 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013.PubMed/NCBI View Article : Google Scholar

3 

Rob L, Halaska M and Robova H: Nerve-sparing and individually tailored surgery for cervical cancer. Lancet Oncol. 11:292–301. 2010.PubMed/NCBI View Article : Google Scholar

4 

Long Y, Yao DS, Pan XW and Ou TY: Clinical efficacy and safety of nerve-sparing radical hysterectomy for cervical cancer: A systematic review and meta-analysis. PLoS One. 9(e94116)2014.PubMed/NCBI View Article : Google Scholar

5 

Ditto A, Martinelli F, Borreani C, Kusamura S, Hanozet F, Brunelli C, Rossi G, Solima E, Fontanelli R, Zanaboni F, et al: Quality of life and sexual, bladder, and intestinal dysfunctions after class III nerve-sparing and class II radical hysterectomies: A questionnaire-based study. Int J Gynecol Cancer. 19:953–957. 2009.PubMed/NCBI View Article : Google Scholar

6 

Kim HS, Choi CH, Lim MC, Chang SJ, Kim YB, Kim MA, Kim TJ, Park SY, Kim BG, Song YS, et al: Safe criteria for less radical trachelectomy in patients with early-stage cervical cancer: A multicenter clinicopathologic study. Ann Surg Oncol. 19:1973–1979. 2012.PubMed/NCBI View Article : Google Scholar

7 

Maas CP, Trimbos JB, DeRuiter MC, Van De Velde CJ and Kenter G: Nerve sparing radical hysterectomy: Latest developments and historical perspective. Crit Rev Oncol. 48:271–279. 2003.PubMed/NCBI View Article : Google Scholar

8 

Querleu D and Morrow CP: Classification of radical hysterectomy. Lancet Oncol. 9:297–303. 2008.PubMed/NCBI View Article : Google Scholar

9 

Höckel M, Konerding MA and Heussel CP: Liposuction-assisted nerve-sparing extended radical hysterectomy: Oncologic rationale, surgical anatomy, and feasibility study. Am J Obstet Gynecol. 178:971–976. 1998.PubMed/NCBI View Article : Google Scholar

10 

van Gent MD, Romijn LM, van Santen KE, Trimbos JB and de Kroon CD: Nerve-sparing radical hysterectomy versus conventional radical hysterectomy in early-stage cervical cancer. A systematic review and meta-analysis of survival and quality of life. Maturitas. 94:30–38. 2016.PubMed/NCBI View Article : Google Scholar

11 

Wu J, Liu X, Hua K, Hu C, Chen X and Lu X: Effect of nerve-sparing radical hysterectomy on bladder function recovery and quality of life in patients with cervical carcinoma. Int J Gynecol Cancer. 20:905–909. 2010.PubMed/NCBI View Article : Google Scholar

12 

Chen C, Li W, Li F, Liu P, Zhou J, Lu L, Su G, Li X, Guo Y and Huang L: Classical and nerve-sparing radical hysterectomy: An evaluation of the nerve trauma in cardinal ligament. Gynecol Oncol. 125:245–251. 2012.PubMed/NCBI View Article : Google Scholar

13 

Kim HS, Kim K, Ryoo SB, Seo JH, Kim SY, Park JW, Kim MA, Hong KS, Jeong CW, Song YS, et al: Conventional versus nerve-sparing radical surgery for cervical cancer: A meta-analysis. J Gynecol Oncol. 26:100–110. 2015.PubMed/NCBI View Article : Google Scholar

14 

Bogani G, Rossetti DO, Ditto A, Signorelli M, Martinelli F, Mosca L, Scaffa C, Leone Roberti Maggiore U, Chiappa V, Sabatucci I, et al: Nerve sparing approach improves outcomes of patients undergoing minimally invasive radical hysterectomy: A systematic review and meta-analysis. J Minim Invasive Gynecol. 25:402–410. 2017.PubMed/NCBI View Article : Google Scholar

15 

Xue Z, Zhu X and Teng Y: Comparison of nerve-sparing radical hysterectomy and radical hysterectomy: A systematic review and meta-analysis. Cell Physiol Biochem. 38:1841–1850. 2016.PubMed/NCBI View Article : Google Scholar

16 

Li B, Zhang R, Wu LY, Zhang GY, Li X and Yu GZ: A prospective study on nerve-sparing radical hysterectomy in patients with cervical cancer. Zhonghua Fu Chan Ke Za Zhi. 43:606–610. 2008.(In Chinese). PubMed/NCBI View Article : Google Scholar

17 

Review Manager (RevMan) [Computer program]. Version 5.3. Copenhagen: Then Nordic Cochrane Centre, The Cochrane Collaboration, 2014.

18 

Gagnier J: The Cochrane risk of bias tool. 2011; Available at: http://bmg.cochrane.org. Accessed July 12, 2016.

19 

Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schünemann HJ and GRADE Working Group: GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 336:924–926. 2008.PubMed/NCBI View Article : Google Scholar

20 

Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA and PRISMA-P Group: Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 4(1)2015.PubMed/NCBI View Article : Google Scholar

21 

Bogani G, Cromi A, Uccella S, Serati M, Casarin J, Pinelli C, Nardelli F and Ghezzi F: Nerve-sparing versus conventional laparoscopic radical hysterectomy: A minimum 12 months' follow-up study. Int J Gynecol Cancer. 24:787–793. 2014.PubMed/NCBI View Article : Google Scholar

22 

Ceccaroni M, Roviglione G, Spagnolo E, Casadio P, Clarizia R, Peiretti M, Bruni F, Peters I and Aletti G: Pelvic dysfunctions and quality of life after nerve-sparing radical hysterectomy: A multicenter comparative study. Anticancer Res. 32:581–588. 2012.PubMed/NCBI

23 

Chen C, Li W, Li F, Liu P, Zhou J, Lu L, Su G, Li X, Guo Y and Huang L: Classical and nerve-sparing radical hysterectomy: an evaluation of the nerve trauma in cardinal ligament. Gynecol Oncol1. 25:245–251. 2012.PubMed/NCBI View Article : Google Scholar

24 

Chen C, Huang L, Liu P, Su G, Li W, Lu L, Wang L, Li X, Duan H, Zou C and Hatch K: Neurovascular quantitative study of the uterosacral ligament related to nerve-sparing radical hysterectomy. Eur J Obstet Gynecol Reprod Biol. 172:74–79. 2014.PubMed/NCBI View Article : Google Scholar

25 

Ditto A, Martinelli F, Mattana F, Reato C, Solima E, Carcangiu M, Haeusler E, Mariani L and Raspagliesi F: Class III nerve-sparing radical hysterectomy versus standard class III radical hysterectomy: An observational study. Ann Surg Oncol. 18:3469–3478. 2011.PubMed/NCBI View Article : Google Scholar

26 

Ditto A, Bogani G, Leone Roberti Maggiore U, Martinelli F, Chiappa V, Lopez C, Perotto S, Lorusso D and Raspagliesi F: Oncologic effectiveness of nerve-sparing radical hysterectomy in cervical cancer. J Gynecol Oncol. 29(e41)2018.PubMed/NCBI View Article : Google Scholar

27 

van Gent MDJM, Rademaker M, van der Veer JCB, van Poelgeest MIE, Gaarenstroom KN, Putter H, Trimbos JBMZ and de Kroon CD: Long-term oncological outcome after conventional radical hysterectomy versus 2 nerve-sparing modalities for early stage cervical cancer. Int J Gynecol Cancer. 27:1729–1736. 2017.PubMed/NCBI View Article : Google Scholar

28 

Kuwabara Y, Suzuki M, Hashimoto M, Furugen Y, Yoshida K and Mitsuhashi N: New method to prevent bladder dysfunction after radical hysterectomy for uterine cervical cancer. J Obstet Gynaecol Res. 26:1–8. 2000.PubMed/NCBI View Article : Google Scholar

29 

Liang Z, Chen Y, Xu H, Li Y and Wang D: Laparoscopic nerve-sparing radical hysterectomy with fascia space dissection technique for cervical cancer: Description of technique and outcomes. Gynecol Oncol. 119:202–207. 2010.PubMed/NCBI View Article : Google Scholar

30 

Liu Z, Li X, Tao Y, Li W, Yang Y, Yao Y and Zhu T: Clinical efficacy and safety of laparoscopic nerve-sparing radical hysterectomy for locally advanced cervical cancer. Int J Surg. 25:54–58. 2016.PubMed/NCBI View Article : Google Scholar

31 

Makowski M, Nowak M, Szpakowski M, Wladzinski J, Serwach-Nowinska A, Janas L and Wilczyński JR: Classical radical hysterectomy and nerve-sparing radical hysterectomy in the treatment of cervical cancer. Prz Menopauzalny. 13:180–185. 2014.PubMed/NCBI View Article : Google Scholar

32 

Possover M, Stober S, Plaul K and Schneider A: Identification and preservation of the motoric innervation of the bladder in radical hysterectomy type III. Gynecol Oncol. 79:154–157. 2000.PubMed/NCBI View Article : Google Scholar

33 

Querleu D, Narducci F, Poulard V, Lacaze S, Occelli B, Leblanc E and Cosson M: Modified radical vaginal hysterectomy with or without laparoscopic nerve-sparing dissection: A comparative study. Gynecol Oncol. 85:154–158. 2002.PubMed/NCBI View Article : Google Scholar

34 

Raspagliesi F, Ditto A, Fontanelli R, Zanaboni F, Solima E, Spatti G, Hanozet F, Vecchione F, Rossi G and Kusamura S: Type II versus Type III nerve-sparing radical hysterectomy: Comparison of lower urinary tract dysfunctions. Gynecol Oncol. 102:256–262. 2006.PubMed/NCBI View Article : Google Scholar

35 

Raspagliesi F, Bogani G, Spinillo A, Ditto A, Bogliolo S, Casarin J, Leone Roberti Maggiore U, Martinelli F, Signorelli M, Gardella B, et al: Introducing nerve-sparing approach during minimally invasive radical hysterectomy for locally-advanced cervical cancer: A multi-institutional experience. Eur J Surg Oncol. 43:2150–2156. 2017.PubMed/NCBI View Article : Google Scholar

36 

Roh J, Lee DO, Suh DH, Lim MC, Seo SS, Chung J, Lee S and Park SY: Efficacy and oncologic safety of nerve-sparing radical hysterectomy for cervical cancer: A randomized controlled trial. J Gynecol Oncol. 26:90–99. 2015.PubMed/NCBI View Article : Google Scholar

37 

Sakuragi N, Todo Y, Kudo M, Yamamoto R and Sato T: A systematic nerve-sparing radical hysterectomy technique in invasive cervical cancer for preserving postsurgical bladder function. Int J Gynecol Cancer. 15:389–397. 2005.PubMed/NCBI View Article : Google Scholar

38 

Shi R, Wei W and Jiang P: Laparoscopic nerve-sparing radical hysterectomy for cervical carcinoma: Emphasis on nerve content in removed cardinal ligaments. Int J Gynecol Cancer. 26:192–198. 2016.PubMed/NCBI View Article : Google Scholar

39 

Skret-Magierlo J, Narog M, Kruczek A, Kluza R, Kluz T, Magon T, Skret A and Wicherek L: Radical hysterectomy during the transition period from traditional to nerve-sparing technique. Gynecol Oncol. 116:502–505. 2010.PubMed/NCBI View Article : Google Scholar

40 

van den Tillaart SA, Kenter GG, Peters AA, Dekker FW, Gaarenstroom KN, Fleuren GJ and Trimbos JB: Nerve-sparing radical hysterectomy: Local recurrence rate, feasibility, and safety in cervical cancer patients stage IA to IIA. Int J Gynecol Cancer. 19:39–45. 2009.PubMed/NCBI View Article : Google Scholar

41 

Tseng CJ, Shen HP, Lin YH, Lee CY and Wei-Cheng Chiu W: A prospective study of nerve-sparing radical hysterectomy for uterine cervical carcinoma in Taiwan. Taiwan J Obstet Gynecol. 51:55–59. 2012.PubMed/NCBI View Article : Google Scholar

42 

Yang Y, Qin T, Zhang W, Wu Q, Yang A and Xu F: Laparoscopic nerve-sparing radical hysterectomy for bulky cervical cancer (≥6 cm) after neoadjuvant chemotherapy: A multicenter prospective cohort study. Int J Surg. 34:35–40. 2016.PubMed/NCBI View Article : Google Scholar

43 

Barnes W, Waggoner S, Delgado G, Maher K, Potkul R, Barter J and Benjamin S: Manometric characterization of rectal dysfunction following radical hysterectomy. Gynecol Oncol. 42:116–119. 1991.PubMed/NCBI View Article : Google Scholar

44 

Long Y, Yao D, Gao K and Xie X: Preliminary study on clinical effect of nerve sparing radical hysterectomy for cervical cancer. Chin Clin Oncol. 15:1083–1090. 2010.

45 

Angioli R, Plotti F, Aloisi A, Scaletta G, Capriglione S, Luvero D, Fiore L, Terranova C, Montera R and Panici PB: A randomized controlled trial comparing four versus six courses of adjuvant platinum-based chemotherapy in locally advanced cervical cancer patients previously treated with neo-adjuvant chemotherapy plus radical surgery. Gynecol Oncol. 139:433–438. 2015.PubMed/NCBI View Article : Google Scholar

46 

Li L, Wu Y, Hu L, Xu H, He H and Hu D: Metastatic nerve root tumor: A case report and literature review. Mol Clin Oncol. 4:1039–1040. 2016.PubMed/NCBI View Article : Google Scholar

47 

Chen L, Zhang WN, Zhang SM, Yang ZH and Zhang P: Effect of laparoscopic nerve-sparing radical hysterectomy on bladder function, intestinal function recovery and quality of sexual life in patients with cervical carcinoma. Asian Pac J Cancer Prev. 15:10971–10975. 2014.PubMed/NCBI View Article : Google Scholar

48 

Tierney JF, Stewart LA, Ghersi D, Burdett S and Sydes MR: Practical methods for incorporating summary time-to-event data into meta-analysis. Trials. 8(16)2007.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lee SH, Bae JW, Han M, Cho YJ, Park JW, Oh SR, Kim SJ, Choe SY, Yun JH, Lee Y, Lee Y, et al: Efficacy of nerve‑sparing radical hysterectomy vs. conventional radical hysterectomy in early‑stage cervical cancer: A systematic review and meta‑analysis. Mol Clin Oncol 12: 160-168, 2020.
APA
Lee, S.H., Bae, J.W., Han, M., Cho, Y.J., Park, J., Oh, S.R. ... Lee, Y. (2020). Efficacy of nerve‑sparing radical hysterectomy vs. conventional radical hysterectomy in early‑stage cervical cancer: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 12, 160-168. https://doi.org/10.3892/mco.2019.1959
MLA
Lee, S. H., Bae, J. W., Han, M., Cho, Y. J., Park, J., Oh, S. R., Kim, S. J., Choe, S. Y., Yun, J. H., Lee, Y."Efficacy of nerve‑sparing radical hysterectomy vs. conventional radical hysterectomy in early‑stage cervical cancer: A systematic review and meta‑analysis". Molecular and Clinical Oncology 12.2 (2020): 160-168.
Chicago
Lee, S. H., Bae, J. W., Han, M., Cho, Y. J., Park, J., Oh, S. R., Kim, S. J., Choe, S. Y., Yun, J. H., Lee, Y."Efficacy of nerve‑sparing radical hysterectomy vs. conventional radical hysterectomy in early‑stage cervical cancer: A systematic review and meta‑analysis". Molecular and Clinical Oncology 12, no. 2 (2020): 160-168. https://doi.org/10.3892/mco.2019.1959
Copy and paste a formatted citation
x
Spandidos Publications style
Lee SH, Bae JW, Han M, Cho YJ, Park JW, Oh SR, Kim SJ, Choe SY, Yun JH, Lee Y, Lee Y, et al: Efficacy of nerve‑sparing radical hysterectomy vs. conventional radical hysterectomy in early‑stage cervical cancer: A systematic review and meta‑analysis. Mol Clin Oncol 12: 160-168, 2020.
APA
Lee, S.H., Bae, J.W., Han, M., Cho, Y.J., Park, J., Oh, S.R. ... Lee, Y. (2020). Efficacy of nerve‑sparing radical hysterectomy vs. conventional radical hysterectomy in early‑stage cervical cancer: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 12, 160-168. https://doi.org/10.3892/mco.2019.1959
MLA
Lee, S. H., Bae, J. W., Han, M., Cho, Y. J., Park, J., Oh, S. R., Kim, S. J., Choe, S. Y., Yun, J. H., Lee, Y."Efficacy of nerve‑sparing radical hysterectomy vs. conventional radical hysterectomy in early‑stage cervical cancer: A systematic review and meta‑analysis". Molecular and Clinical Oncology 12.2 (2020): 160-168.
Chicago
Lee, S. H., Bae, J. W., Han, M., Cho, Y. J., Park, J., Oh, S. R., Kim, S. J., Choe, S. Y., Yun, J. H., Lee, Y."Efficacy of nerve‑sparing radical hysterectomy vs. conventional radical hysterectomy in early‑stage cervical cancer: A systematic review and meta‑analysis". Molecular and Clinical Oncology 12, no. 2 (2020): 160-168. https://doi.org/10.3892/mco.2019.1959
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team