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Lenvatinib vs. palliative therapy for stage IVC anaplastic thyroid cancer

  • Authors:
    • Hiroyuki Iwasaki
    • Soji Toda
    • Nobuyasu Suganuma
    • Daisuke Murayama
    • Hirotaka Nakayama
    • Katsuhiko Masudo
  • View Affiliations / Copyright

    Affiliations: Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, Yokohama, Kanagawa 241‑8515, Japan, Department of Surgical Treatment, Yokohama City University Hospital, Yokohama, Kanagawa 236‑0004, Japan, Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, Kanagawa 232‑0024, Japan
    Copyright: © Iwasaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 138-143
    |
    Published online on: December 13, 2019
       https://doi.org/10.3892/mco.2019.1964
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Abstract

Anaplastic thyroid cancer (ATC) is an orphan disease with extremely poor prognosis. In particular, unresectable stage IVC ATC is extremely difficult to treat and is associated with a survival of only a few months, even when treated with irradiation and/or chemotherapy. In 2015, lenvatinib was approved for the treatment of ATC in Japan. The aim of the present study was to evaluate the efficacy of lenvatinib for stage IVC ATC. A total of 32 patients with pathologically confirmed stage IVC ATC who were treated at the Kanagawa Cancer Center between 2011 and 2018 were included in the present study, of whom 16 patients were treated with lenvatinib (L group). The remaining 16 patients received palliative therapy (P group), of whom 7 were treated with weekly paclitaxel, 2 received external radiation for tumor reduction 5 days per week until treatment completion, and 2 underwent tracheostomy to avoid the risk of asphyxiation. The survival curves of both groups were analyzed using the log‑rank test. The median overall survival time of the L and P groups was 4.2 and 2.0 months, respectively. A significant survival benefit was observed in the L group compared with that in the P group (P=0.00298). A reduction in tumor size by ≥30% (clinical partial response) within 1 month after treatment was observed in 5 patients (31.3%) in the L group and in no patients in the P group. Therefore, lenvatinib treatment yielded a median survival benefit of ~2 months compared with palliative therapy in stage IVC ATC. However, although a reduction in tumor size by ≥30% was confirmed in 5 patients who received lenvatinib treatment, 2 of those patients succumbed to massive necrosis and bleeding. These results suggest that an appropriate lenvatinib dose reduction is necessary.
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1 

Oh EM, Lee KE, Kwon H, Kim EY, Bae DS and Youn YK: Analysis of patients with anaplastic thyroid cancer expected to have curative surgery. J Korean Surg Soc. 83:123–129. 2012.PubMed/NCBI View Article : Google Scholar

2 

Shimaoka K, Schoenfeld DA, DeWys WD, Creech RH and DeConti R: A randomized trial of doxorubicin versus doxorubicin plus cisplatin in patients with advanced thyroid carcinoma. Cancer. 56:2155–2160. 1985.PubMed/NCBI View Article : Google Scholar

3 

Mooney CJ, Nagaiah G, Fu P, Wasman JK, Cooney MM, Savvides PS, Bokar JA, Dowlati A, Wang D, Agarwala SS, et al: A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome. Thyroid. 19:233–240. 2009.PubMed/NCBI View Article : Google Scholar

4 

Sosa JA, Elisei R, Jarzab B, Balkissoon J, Lu SP, Bal C, Marur S, Gramza A, Yosef RB, Gitlitz B, et al: Randomized safety and efficacy study of fosbretabulin with paclitaxel/carboplatin against anaplastic thyroid carcinoma. Thyroid. 24:232–240. 2014.PubMed/NCBI View Article : Google Scholar

5 

Bisof V, Rakusic Z and Despot M: Treatment of patients with anaplastic thyroid cancer during the last 20 years: Whether any progress has been made? Eur Arch Otorhinolaryngol. 272:1553–1567. 2015.PubMed/NCBI View Article : Google Scholar

6 

Smallridge RC, Ain KB, Asa SL, Bible KC, Brierley JD, Burman KD, Kebebew E, Lee NY, Nikiforov YE, Rosenthal MS, et al: American thyroid association guidelines for management of patients with anaplastic thyroid cancer. Thyroid. 22:1104–1139. 2012.PubMed/NCBI View Article : Google Scholar

7 

Iwasaki H, Yamazaki H, Suganuma N, Nakayama H, Toda S and Masudo K: Role of tyrosine kinase inhibitor thyrapy in anaplastic thyroid cancer. Int J Recent Adv Multidisciplinary Res. 05:4270–4274. 2018.

8 

Iwasaki H, Yamazaki H, Takasaki H, Suganuma N, Nakayama H, Toda S and Masudo K: Lenvatinib as a novel treatment for anaplastic thyroid cancer: A retrospective study. Oncol Lett. 16:7271–7277. 2018.PubMed/NCBI View Article : Google Scholar

9 

Venkatesh YS, Ordonez NG, Schultz PN, Hickey RC, Goepfert H and Samaan NA: Anaplastic carcinoma of the thyroid. A clinicopathologic study of 121 cases. Cancer. 66:321–330. 1990.PubMed/NCBI View Article : Google Scholar

10 

Kebebew E, Greenspan FS, Clark OH, Woeber KA and McMillan A: Anaplastic thyroid carcinoma. Treatment outcome and prognostic factors. Cancer. 103:1330–1335. 2005.PubMed/NCBI View Article : Google Scholar

11 

Onoda N, Sugino K, Higashiyama T, Kammori M, Toda K, Ito K, Yoshida A, Suganuma N, Nakashima N, Suzuki S, et al: The safety and efficacy of weekly paclitaxel administration for anaplastic thyroid cancer patients: A nationwide prospective study. Thyroid. 26:1293–1299. 2016.PubMed/NCBI View Article : Google Scholar

12 

Pozdeyev N, Gay LM, Sokol ES, Hartmaier R, Deaver KE, Davis S, French JD, Borre PV, LaBarbera DV, Tan AC, et al: Genetic analysis of 779 advanced differentiated and anaplastic thyroid cancers. Clin Cancer Res. 24:3059–3068. 2018.PubMed/NCBI View Article : Google Scholar

13 

Begum S, Rosenbaum E, Henrique R, Cohen Y, Sidransky D and Westra WH: BRAF mutations in anaplastic thyroid carcinoma: Implications for tumor origin, diagnosis and treatment. Mod Pathol. 17:1359–1363. 2004.PubMed/NCBI

14 

McIver B, Hay ID, Giuffrida DF, Dvorak CE, Grant CS, Thompson GB, van Heerden JA and Goellner JR: Anaplastic thyroid carcinoma: A 50-year experience at a single institution. Surgery. 130:1028–1034. 2001.PubMed/NCBI View Article : Google Scholar

15 

Pacheco-Ojeda LA, Martinez AL and Alvarez M: Anaplastic thyroid carcinoma in ecuador: Analysis of prognostic factors. Int Surg. 86:117–121. 2001.PubMed/NCBI

16 

Takashima S, Morimoto S, Ikezoe J, Takai S, Kobayashi T, Koyama H, Nishiyama K and Kozuka T: CT evaluation of anaplastic thyroid carcinoma. AJR Am J Roentgenol. 154:1079–1085. 1990.PubMed/NCBI View Article : Google Scholar

17 

Yamazaki H, Iwasaki H, Takasaki H, Suganuma N, Sakai R, Masudo K, Nakayama H, Rino Y and Masuda M: Efficacy and tolerability of initial low-dose lenvatinib to treat differentiated thyroid cancer. Medicine (Baltimore). 98(e14774)2019.PubMed/NCBI View Article : Google Scholar

18 

Subbiah V, Kreitman RJ, Wainberg ZA, Cho JY, Schellens JHM, Soria JC, Wen PY, Zielinski C, Cabanillas ME, Urbanowitz G, et al: Dabrafenib and trametinib treatment in patients with locally advanced or metastatic BRAF V600-mutant anaplastic thyroid cancer. J Clin Oncol. 36:7–13. 2018.PubMed/NCBI View Article : Google Scholar

19 

Bastman JJ, Serracino HS, Zhu Y, Koenig MR, Mateescu V, Sams SB, Davies KD, Raeburn CD, McIntyre RC Jr, Haugen BR, et al: Tumor-Infiltrating T cells and the PD-1 checkpoint pathway in advanced differentiated and anaplastic thyroid cancer. J Clin Endocrinol Metab. 101:2863–2873. 2016.PubMed/NCBI View Article : Google Scholar

20 

Vanden Borre P, Gunda V, McFadden DG, Sadow PM, Varmeh S, Bernasconi M, Parangi S, et al: Combined BRAF(V600E)-and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer. Oncotarget. 5:3996–4010. 2014.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Iwasaki H, Toda S, Suganuma N, Murayama D, Nakayama H and Masudo K: Lenvatinib vs. palliative therapy for stage IVC anaplastic thyroid cancer. Mol Clin Oncol 12: 138-143, 2020.
APA
Iwasaki, H., Toda, S., Suganuma, N., Murayama, D., Nakayama, H., & Masudo, K. (2020). Lenvatinib vs. palliative therapy for stage IVC anaplastic thyroid cancer. Molecular and Clinical Oncology, 12, 138-143. https://doi.org/10.3892/mco.2019.1964
MLA
Iwasaki, H., Toda, S., Suganuma, N., Murayama, D., Nakayama, H., Masudo, K."Lenvatinib vs. palliative therapy for stage IVC anaplastic thyroid cancer". Molecular and Clinical Oncology 12.2 (2020): 138-143.
Chicago
Iwasaki, H., Toda, S., Suganuma, N., Murayama, D., Nakayama, H., Masudo, K."Lenvatinib vs. palliative therapy for stage IVC anaplastic thyroid cancer". Molecular and Clinical Oncology 12, no. 2 (2020): 138-143. https://doi.org/10.3892/mco.2019.1964
Copy and paste a formatted citation
x
Spandidos Publications style
Iwasaki H, Toda S, Suganuma N, Murayama D, Nakayama H and Masudo K: Lenvatinib vs. palliative therapy for stage IVC anaplastic thyroid cancer. Mol Clin Oncol 12: 138-143, 2020.
APA
Iwasaki, H., Toda, S., Suganuma, N., Murayama, D., Nakayama, H., & Masudo, K. (2020). Lenvatinib vs. palliative therapy for stage IVC anaplastic thyroid cancer. Molecular and Clinical Oncology, 12, 138-143. https://doi.org/10.3892/mco.2019.1964
MLA
Iwasaki, H., Toda, S., Suganuma, N., Murayama, D., Nakayama, H., Masudo, K."Lenvatinib vs. palliative therapy for stage IVC anaplastic thyroid cancer". Molecular and Clinical Oncology 12.2 (2020): 138-143.
Chicago
Iwasaki, H., Toda, S., Suganuma, N., Murayama, D., Nakayama, H., Masudo, K."Lenvatinib vs. palliative therapy for stage IVC anaplastic thyroid cancer". Molecular and Clinical Oncology 12, no. 2 (2020): 138-143. https://doi.org/10.3892/mco.2019.1964
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