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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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March-2020 Volume 12 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

A comparative study of nivolumab and axitinib in terms of overall survival, treatment continuation, and cost for patients with metastatic renal cell carcinoma

  • Authors:
    • Michio Kimura
    • Eiseki Usami
    • Hitomi Teramachi
    • Tomoaki Yoshimura
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Gifu 503‑8502, Japan, Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Gifu 501‑1196, Japan
  • Pages: 284-289
    |
    Published online on: January 16, 2020
       https://doi.org/10.3892/mco.2020.1978
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Abstract

Nivolumab and axitinib has recommended as a second‑line treatment in patients with metastatic renal cell carcinoma (mRCC) after tyrosine kinase inhibitor treatment. In this study, overall survival (OS), treatment continuation, and the cost of nivolumab and axitinib‑the second‑line treatment agents for mRCC‑were compared and examined. Herein, we retrospectively surveyed patients with pathologically confirmed mRCC, treated with nivolumab (n=9) or axitinib (n=16) at Ogaki Municipal Hospital (Ogaki, Japan) between January 2012 and May 2019. The treatment periods for the nivolumab‑ and axitinib‑administered groups were 5.4 (range: 1.4‑21.3) and 3.4 (range: 0.3-28.1) months, respectively (P=0.089). The postponement periods for the nivolumab‑ and axitinib‑administered groups were 7 (range: 0‑186) and 0 (range: 0‑262) days, respectively, and the difference was statistically significant (P=0.008). The median OS for patients treated with nivolumab and axitinib was 12.3 (range: 1.5‑25.5 months) and 9.2 (range: 2.2‑55.0 months) months, respectively (P=0.633). The one‑year cost estimates for axitinib and nivolumab in clinical practice were $60,694.2 and $86,544.4, respectively (P=0.017). We found that despite frequent interruptions in nivolumab administration and a longer postpaonement period for the nivolumab‑administered group than for the axitinib‑administered group, both groups exhibit comparable treatment duration and OS.
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Copy and paste a formatted citation
Spandidos Publications style
Kimura M, Usami E, Teramachi H and Yoshimura T: A comparative study of nivolumab and axitinib in terms of overall survival, treatment continuation, and cost for patients with metastatic renal cell carcinoma. Mol Clin Oncol 12: 284-289, 2020.
APA
Kimura, M., Usami, E., Teramachi, H., & Yoshimura, T. (2020). A comparative study of nivolumab and axitinib in terms of overall survival, treatment continuation, and cost for patients with metastatic renal cell carcinoma. Molecular and Clinical Oncology, 12, 284-289. https://doi.org/10.3892/mco.2020.1978
MLA
Kimura, M., Usami, E., Teramachi, H., Yoshimura, T."A comparative study of nivolumab and axitinib in terms of overall survival, treatment continuation, and cost for patients with metastatic renal cell carcinoma". Molecular and Clinical Oncology 12.3 (2020): 284-289.
Chicago
Kimura, M., Usami, E., Teramachi, H., Yoshimura, T."A comparative study of nivolumab and axitinib in terms of overall survival, treatment continuation, and cost for patients with metastatic renal cell carcinoma". Molecular and Clinical Oncology 12, no. 3 (2020): 284-289. https://doi.org/10.3892/mco.2020.1978
Copy and paste a formatted citation
x
Spandidos Publications style
Kimura M, Usami E, Teramachi H and Yoshimura T: A comparative study of nivolumab and axitinib in terms of overall survival, treatment continuation, and cost for patients with metastatic renal cell carcinoma. Mol Clin Oncol 12: 284-289, 2020.
APA
Kimura, M., Usami, E., Teramachi, H., & Yoshimura, T. (2020). A comparative study of nivolumab and axitinib in terms of overall survival, treatment continuation, and cost for patients with metastatic renal cell carcinoma. Molecular and Clinical Oncology, 12, 284-289. https://doi.org/10.3892/mco.2020.1978
MLA
Kimura, M., Usami, E., Teramachi, H., Yoshimura, T."A comparative study of nivolumab and axitinib in terms of overall survival, treatment continuation, and cost for patients with metastatic renal cell carcinoma". Molecular and Clinical Oncology 12.3 (2020): 284-289.
Chicago
Kimura, M., Usami, E., Teramachi, H., Yoshimura, T."A comparative study of nivolumab and axitinib in terms of overall survival, treatment continuation, and cost for patients with metastatic renal cell carcinoma". Molecular and Clinical Oncology 12, no. 3 (2020): 284-289. https://doi.org/10.3892/mco.2020.1978
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