Open Access

Lack of association between Screencell-detected circulating tumour cells and long‑term survival of patients undergoing surgery for non‑small cell lung cancer: A pilot clinical study

  • Authors:
    • James Barr
    • Dimple Chudasama
    • Alex Rice
    • Emmanouil Karteris
    • Vladimir Anikin
  • View Affiliations

  • Published online on: January 21, 2020     https://doi.org/10.3892/mco.2020.1981
  • Pages: 191-195
  • Copyright: © Barr et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circulating tumour cells (CTCs) are cancer cells of epithelial origin that are present in peripheral blood samples. ScreenCell detection of CTCs and the association with long term survival in non‑small cell lung cancer (NSCLC) patients was evaluated in the present study. A total of 33 patients undergoing surgical resection for NSCLC were recruited. Patients were followed up for 5‑years post‑operatively. Pre‑operative patient bloods samples were processed using ScreenCell. CTCs were detected in 26 (79%) patients. In patients who were positive for CTCs, a total of 9 (35%) patients succumbed to the disease, whereas in patients negative for CTCs, a total of 4 (57%) patients succumbed to the disease (P=0.29). No association was identified between positive CTCs and poorer survival (Chi‑squared 1.47, P=0.23; hazard ratio, 0.42; 95% confidence interval: 0.1‑1.7). The presence of CTCs detected with ScreenCell does not influence prognosis in patients with NSCLC that was operated on. The high rate of CTC detection is encouraging in supporting this technology to aid early lung cancer diagnosis.
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March 2020
Volume 12 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Barr, J., Chudasama, D., Rice, A., Karteris, E., & Anikin, V. (2020). Lack of association between Screencell-detected circulating tumour cells and long‑term survival of patients undergoing surgery for non‑small cell lung cancer: A pilot clinical study. Molecular and Clinical Oncology, 12, 191-195. https://doi.org/10.3892/mco.2020.1981
MLA
Barr, J., Chudasama, D., Rice, A., Karteris, E., Anikin, V."Lack of association between Screencell-detected circulating tumour cells and long‑term survival of patients undergoing surgery for non‑small cell lung cancer: A pilot clinical study". Molecular and Clinical Oncology 12.3 (2020): 191-195.
Chicago
Barr, J., Chudasama, D., Rice, A., Karteris, E., Anikin, V."Lack of association between Screencell-detected circulating tumour cells and long‑term survival of patients undergoing surgery for non‑small cell lung cancer: A pilot clinical study". Molecular and Clinical Oncology 12, no. 3 (2020): 191-195. https://doi.org/10.3892/mco.2020.1981