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Indicators for secondary carcinoma in head and neck cancer patients following curative therapy: A retrospective clinical study

  • Authors:
    • Beatrice Kuhlin
    • Benedikt Kramer
    • Vytis Nefas
    • Nicole Rotter
    • Christoph Aderhold
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology‑Head and Neck Surgery, University Hospital Mannheim, D-68167 Mannheim, Germany
    Copyright: © Kuhlin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 403-410
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    Published online on: February 26, 2020
       https://doi.org/10.3892/mco.2020.2004
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Abstract

Patients with head and neck squamous cell carcinoma (HNSCC) are at risk for local and regional relapse, as well as for occurrence of synchronous or metachronous secondary carcinoma. The aim of this retrospective study was to evaluate the frequency of secondary malignancies amongst HNSCC patients and their association with age, sex and TNM classification, as well as smoking and alcohol abuse. Data from 394 patients with HNSCC who were treated at the Department of Otorhinolaryngology‑Head and Neck Surgery of the University Hospital Mannheim between 2011 and 2015 were retrieved and analyzed using t‑tests and P≤0.05 was considered statistically significant. Of the 394 patients, 50 (12.7%) developed a secondary carcinoma. In this cohort, >70% of secondary malignancies were diagnosed using clinical inspection or microlaryngoscopy. The majority of secondary malignancies were identified in the oropharynx, with men being more often affected overall. Continued abuse of carcinogenic substances appeared to increase the incidence of secondary carcinoma, whereas the localization of the primary tumor, age, sex or TNM classification were not identified as significant indicators of the occurrence of a secondary carcinoma. The purpose of the present study was to emphasize the importance of intensive follow‑up to ensure early detection of secondary malignancies. The aim was to help predict numbers and occurrence within smaller cohorts, and to evaluate the quality of data collected during the establishment of a certified tumor center. To fully evaluate the role of continued exposure to noxious substances and other possible contributing factors, and in order to improve the rate of early diagnosis and establish preventive strategies, multicentered studies with larger cohorts are required.
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Copy and paste a formatted citation
Spandidos Publications style
Kuhlin B, Kramer B, Nefas V, Rotter N and Aderhold C: Indicators for secondary carcinoma in head and neck cancer patients following curative therapy: A retrospective clinical study. Mol Clin Oncol 12: 403-410, 2020.
APA
Kuhlin, B., Kramer, B., Nefas, V., Rotter, N., & Aderhold, C. (2020). Indicators for secondary carcinoma in head and neck cancer patients following curative therapy: A retrospective clinical study. Molecular and Clinical Oncology, 12, 403-410. https://doi.org/10.3892/mco.2020.2004
MLA
Kuhlin, B., Kramer, B., Nefas, V., Rotter, N., Aderhold, C."Indicators for secondary carcinoma in head and neck cancer patients following curative therapy: A retrospective clinical study". Molecular and Clinical Oncology 12.5 (2020): 403-410.
Chicago
Kuhlin, B., Kramer, B., Nefas, V., Rotter, N., Aderhold, C."Indicators for secondary carcinoma in head and neck cancer patients following curative therapy: A retrospective clinical study". Molecular and Clinical Oncology 12, no. 5 (2020): 403-410. https://doi.org/10.3892/mco.2020.2004
Copy and paste a formatted citation
x
Spandidos Publications style
Kuhlin B, Kramer B, Nefas V, Rotter N and Aderhold C: Indicators for secondary carcinoma in head and neck cancer patients following curative therapy: A retrospective clinical study. Mol Clin Oncol 12: 403-410, 2020.
APA
Kuhlin, B., Kramer, B., Nefas, V., Rotter, N., & Aderhold, C. (2020). Indicators for secondary carcinoma in head and neck cancer patients following curative therapy: A retrospective clinical study. Molecular and Clinical Oncology, 12, 403-410. https://doi.org/10.3892/mco.2020.2004
MLA
Kuhlin, B., Kramer, B., Nefas, V., Rotter, N., Aderhold, C."Indicators for secondary carcinoma in head and neck cancer patients following curative therapy: A retrospective clinical study". Molecular and Clinical Oncology 12.5 (2020): 403-410.
Chicago
Kuhlin, B., Kramer, B., Nefas, V., Rotter, N., Aderhold, C."Indicators for secondary carcinoma in head and neck cancer patients following curative therapy: A retrospective clinical study". Molecular and Clinical Oncology 12, no. 5 (2020): 403-410. https://doi.org/10.3892/mco.2020.2004
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