Extramedullary nasal plasmacytoma arising after polyp excision and the role of the inflammation in tumor development: A case report

Di Stadio,Arianna; Gambacorta,Valeria; De Crescenzo,Stefano; Sidoni,Angelo; Cristi,Maria  Cristina; Di Giovanni,Alfredo; Maranzano,Massimo; Ricci,Giampietro

doi:10.3892/mco.2020.2007

Extramedullary nasal plasmacytoma arising after polyp excision and the role of the inflammation in tumor development: A case report

Authors:
- Arianna Di Stadio
- Valeria Gambacorta
- Stefano De Crescenzo
- Angelo Sidoni
- Maria Cristina Cristi
- Alfredo Di Giovanni
- Massimo Maranzano
- Giampietro Ricci
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Affiliations: Department of Otolaryngology, University of Perugia, I‑65121 Perugia, Italy, Department of Anatomic Pathology, University of Perugia, I‑65121 Perugia, Italy, Department of Otolaryngology, Silvestrini Hospital, I‑65121 Perugia, Italy, Department of Oral Maxillo-Facial and Facial Plastic Surgery, University of Manchester, Manchester M13 9PL, UK
Published online on: February 26, 2020 https://doi.org/10.3892/mco.2020.2007
Pages: 451-455
Copyright: © Di Stadio et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A correlation between inflammation and cancer has been identified in the case of nasal cancer, however a specific connection between nasal inflammation and extramedullary nasal plasmacytoma (ENP), to the best of our knowledge, has not yet been determined. The present case report describes a patient affected by ENP, in who the tumor arose in the same area, from which a nasal polyp was previously surgically removed, five months after the polyp excision. The patient underwent surgical endoscopic tumor asportation without being treated with radio‑chemotherapy. ENP was totally removed via surgery and no signs of recurrence were identified by endoscopy or magnetic resonance imaging during the last check‑up 1 year after tumor asportation. It was hypothesized that in this elderly patient, who was exposed to viral infections and pollution for several years, ENP may be correlated to the inflammatory process that occurred after surgery, and this likely contributed to a neoplastic mutation in B‑cells.

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