Open Access

Central venous catheterization in cancer patients with severe thrombocytopenia: Ultrasound‑guide improves safety avoiding prophylactic platelet transfusion

  • Authors:
    • Luigi Cavanna
    • Chiara Citterio
    • Camilla Di Nunzio
    • Elena Orlandi
    • Ilaria Toscani
    • Massimo Ambroggi
  • View Affiliations

  • Published online on: March 5, 2020     https://doi.org/10.3892/mco.2020.2010
  • Pages: 435-439
  • Copyright: © Cavanna et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Prior research has revealed that ultrasound (US) guided central venous catheterization (CVC) is associated with a reduction in the complication rate such as pneumothorax and an improved first‑pass success placing CVC in the internal jugular vein. The present study investigated if US‑guided CVC, in a subset of cancer patients with severe thrombocytopenia, reduced bleeding risk and avoided prophylactic platelet transfusion. The efficacy and safety of US‑guided CVC placement in cancer patients with severe thrombocytopenia was retrospectively analyzed over a period of 9 years (Dec 2000‑Jan 2009), 1,660 and 207 patients with cancer underwent US‑guided CVC placement into internal jugular vein respectively at the Department of Onco‑Haematology, Hospital of Piacenza. The first group of patients included patients in active antitumor treatment, while the second group included patients in the palliative phase. A total of 110 (5.89%) of these 1,867 patients exhibited severe thrombocytopenia defined as platelet count ≤20x109/l, and formed the basis of this study. All procedures were evaluated for bleeding complications as defined by the National Institute of Health Common Terminology Criteria for Adverse Events (CTCAE 3.0). In the subgroup of the 110 patients with severe thrombocytopenia a single needle puncture of the vein was employed in 121 of the 122 procedures (99.18%) and no attempt failures were registered. No pneumothorax, no major bleeding and no nerve and arterial puncture were reported, only one self‑limiting hematoma (0.90%) at the site of CVC insertion was reported (CTCAE 3.0 grade 1). No platelet transfusions were performed in the 110 patients, pre and post CVC placement. We believe that US‑guided CVC insertion procedures into the internal jugular vein makes the difference in safety, also in thrombocytopenic patients avoiding prophylactic or post procedure platelet transfusion.
View References

Related Articles

Journal Cover

May 2020
Volume 12 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Cavanna, L., Citterio, C., Di Nunzio, C., Orlandi, E., Toscani, I., & Ambroggi, M. (2020). Central venous catheterization in cancer patients with severe thrombocytopenia: Ultrasound‑guide improves safety avoiding prophylactic platelet transfusion. Molecular and Clinical Oncology, 12, 435-439. https://doi.org/10.3892/mco.2020.2010
MLA
Cavanna, L., Citterio, C., Di Nunzio, C., Orlandi, E., Toscani, I., Ambroggi, M."Central venous catheterization in cancer patients with severe thrombocytopenia: Ultrasound‑guide improves safety avoiding prophylactic platelet transfusion". Molecular and Clinical Oncology 12.5 (2020): 435-439.
Chicago
Cavanna, L., Citterio, C., Di Nunzio, C., Orlandi, E., Toscani, I., Ambroggi, M."Central venous catheterization in cancer patients with severe thrombocytopenia: Ultrasound‑guide improves safety avoiding prophylactic platelet transfusion". Molecular and Clinical Oncology 12, no. 5 (2020): 435-439. https://doi.org/10.3892/mco.2020.2010