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Article

Corticosteroids alleviate adverse events associated with enzalutamide in patients with metastatic castration‑resistant prostate cancer

  • Authors:
    • Keita Tamura
    • Yuto Matsushita
    • Hiromitsu Watanabe
    • Daisuke Motoyama
    • Toshiki Ito
    • Takayuki Sugiyama
    • Atsushi Otsuka
    • Hideaki Miyake
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431‑3192, Japan
  • Pages: 495-500
    |
    Published online on: March 5, 2020
       https://doi.org/10.3892/mco.2020.2013
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Abstract

The aim of the present study was to investigate the impact of the combined use of corticosteroid on adverse events (AEs) induced by enzalutamide (Enz) in patients with metastatic castration‑resistant prostate cancer (mCRPC). The cohort of the present study included 121 consecutive patients with mCRPC who sequentially received androgen receptor‑axis‑targeted (ARAT) agents, abiraterone acetate (AA) and Enz, in any order, without prior docetaxel therapy. Detailed assessments of AEs during treatment with Enz were conducted according to whether or not corticosteroid was administered. Of these patients, 63 and 58 received ARAT therapy with the Enz‑to‑AA sequence (group 1) and the AA‑to‑Enz sequence (group 2), respectively. No patient in group 1 received corticosteroid during treatment with Enz, while corticosteroid was continuously administered in combination with Enz to all patients in group 2 following AA failure. When ARAT therapy was initiated, no significant differences in the major baseline characteristics were observed between the two groups. During Enz therapy, there were no significant differences in the incidence of any AEs or AEs ≥ grade 3 between the two groups. However, the incidences of fatigue and appetite loss in group 1 were significantly higher when compared with those in group 2. Furthermore, the combined use of corticosteroid was revealed to be independently associated with the prevention of fatigue and appetite loss during Enz therapy. The results of the present study suggested that the combined use of corticosteroids could reduce the incidence of certain types of AE, particularly fatigue and appetite loss, in mCRPC patients treated with Enz.
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Copy and paste a formatted citation
Spandidos Publications style
Tamura K, Matsushita Y, Watanabe H, Motoyama D, Ito T, Sugiyama T, Otsuka A and Miyake H: Corticosteroids alleviate adverse events associated with enzalutamide in patients with metastatic castration‑resistant prostate cancer. Mol Clin Oncol 12: 495-500, 2020.
APA
Tamura, K., Matsushita, Y., Watanabe, H., Motoyama, D., Ito, T., Sugiyama, T. ... Miyake, H. (2020). Corticosteroids alleviate adverse events associated with enzalutamide in patients with metastatic castration‑resistant prostate cancer. Molecular and Clinical Oncology, 12, 495-500. https://doi.org/10.3892/mco.2020.2013
MLA
Tamura, K., Matsushita, Y., Watanabe, H., Motoyama, D., Ito, T., Sugiyama, T., Otsuka, A., Miyake, H."Corticosteroids alleviate adverse events associated with enzalutamide in patients with metastatic castration‑resistant prostate cancer". Molecular and Clinical Oncology 12.5 (2020): 495-500.
Chicago
Tamura, K., Matsushita, Y., Watanabe, H., Motoyama, D., Ito, T., Sugiyama, T., Otsuka, A., Miyake, H."Corticosteroids alleviate adverse events associated with enzalutamide in patients with metastatic castration‑resistant prostate cancer". Molecular and Clinical Oncology 12, no. 5 (2020): 495-500. https://doi.org/10.3892/mco.2020.2013
Copy and paste a formatted citation
x
Spandidos Publications style
Tamura K, Matsushita Y, Watanabe H, Motoyama D, Ito T, Sugiyama T, Otsuka A and Miyake H: Corticosteroids alleviate adverse events associated with enzalutamide in patients with metastatic castration‑resistant prostate cancer. Mol Clin Oncol 12: 495-500, 2020.
APA
Tamura, K., Matsushita, Y., Watanabe, H., Motoyama, D., Ito, T., Sugiyama, T. ... Miyake, H. (2020). Corticosteroids alleviate adverse events associated with enzalutamide in patients with metastatic castration‑resistant prostate cancer. Molecular and Clinical Oncology, 12, 495-500. https://doi.org/10.3892/mco.2020.2013
MLA
Tamura, K., Matsushita, Y., Watanabe, H., Motoyama, D., Ito, T., Sugiyama, T., Otsuka, A., Miyake, H."Corticosteroids alleviate adverse events associated with enzalutamide in patients with metastatic castration‑resistant prostate cancer". Molecular and Clinical Oncology 12.5 (2020): 495-500.
Chicago
Tamura, K., Matsushita, Y., Watanabe, H., Motoyama, D., Ito, T., Sugiyama, T., Otsuka, A., Miyake, H."Corticosteroids alleviate adverse events associated with enzalutamide in patients with metastatic castration‑resistant prostate cancer". Molecular and Clinical Oncology 12, no. 5 (2020): 495-500. https://doi.org/10.3892/mco.2020.2013
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