High proportions of CD3+ T cells in grafts delayed lymphocyte recovery and reduced overall survival in haploidentical peripheral blood stem cell transplantation

  • Authors:
    • Ying Zhang
    • Caili Guo
    • Chunhong Sun
    • Ying Chen
    • Huachao Zhu
    • Jieying Xi
    • Mei Zhang
    • Pengcheng He
    • Xiaoning Wang
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  • Published online on: April 2, 2020     https://doi.org/10.3892/mco.2020.2027
  • Pages: 574-580
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

T cells in grafts serve an important role in the pathogenesis of graft versus host disease (GVHD) and immune recovery during HLA matched allogeneic stem cell transplantation. However, the role of T cells in the haploidentical peripheral blood stem cell transplantation (Haplo‑PBSCT) is yet to be determined. In the present study, the role of CD3+ T cells in grafts and impact on hematopoietic and immune recovery, cytomegalovirus (CMV) reactivation, GVHD, relapse, progress free survival and overall survival (OS) were evaluated and analyzed. A total of 30 patients who underwent haplo‑PBSCT were included in the present study. CD3+ T cells accounted for a median of 23.1% (range 8‑47.4%) with a median dose of 299.7x106/kg (range 104‑623.4). Patients were divided into two groups according to the CD3+ T cell count: Above the median (high T cell group) and below the median CD3+ T cell (low T cell group). No significant difference was identified between neutrophil and platelet recovery time between two groups (P>0.05). The mean lymphocyte recovery time of high T cell group and low T cell group were 107.07 days (95% CI 79.88‑134.25), and 50.4 days (95% CI 41.42‑59.38), respectively. The lymphocyte recovery time of high T cell group was higher that of low T cell group (P<0.05). No significant difference between CMV reactivation, chronic GVHD and primary disease relapse rates was observed between two groups (P>0.05). The cumulative incidence of grade II or above acute GVHD was higher in the high T groups compared with low T groups (P<0.05). The overall survival and progress free survival rates were higher in the low T cell group compared with the high T cell group (P<0.05). In conclusion, high levels of CD3+ T cells in the grafts were associated with delayed lymphocyte recovery and an increased risk of acute GVHD and decreased overall survival.
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June-2020
Volume 12 Issue 6

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Spandidos Publications style
Zhang Y, Guo C, Sun C, Chen Y, Zhu H, Xi J, Zhang M, He P and Wang X: High proportions of CD3+ T cells in grafts delayed lymphocyte recovery and reduced overall survival in haploidentical peripheral blood stem cell transplantation. Mol Clin Oncol 12: 574-580, 2020
APA
Zhang, Y., Guo, C., Sun, C., Chen, Y., Zhu, H., Xi, J. ... Wang, X. (2020). High proportions of CD3+ T cells in grafts delayed lymphocyte recovery and reduced overall survival in haploidentical peripheral blood stem cell transplantation. Molecular and Clinical Oncology, 12, 574-580. https://doi.org/10.3892/mco.2020.2027
MLA
Zhang, Y., Guo, C., Sun, C., Chen, Y., Zhu, H., Xi, J., Zhang, M., He, P., Wang, X."High proportions of CD3+ T cells in grafts delayed lymphocyte recovery and reduced overall survival in haploidentical peripheral blood stem cell transplantation". Molecular and Clinical Oncology 12.6 (2020): 574-580.
Chicago
Zhang, Y., Guo, C., Sun, C., Chen, Y., Zhu, H., Xi, J., Zhang, M., He, P., Wang, X."High proportions of CD3+ T cells in grafts delayed lymphocyte recovery and reduced overall survival in haploidentical peripheral blood stem cell transplantation". Molecular and Clinical Oncology 12, no. 6 (2020): 574-580. https://doi.org/10.3892/mco.2020.2027