Expression of androgen receptor and its regulatory molecule Lin28 in non‑luminal subtype breast cancer

Sa‑Nguanraksa,Doonyapat; Pongthong,Wanee; Samarnthai,Norasate; Mitpakdi,Kwanlada; Chuangsuwanich,Tuenjai; Limjindaporn,Thawornchai; Kulprom,Anchalee; O‑Charoenrat,Pornchai

doi:10.3892/mco.2020.2029

Expression of androgen receptor and its regulatory molecule Lin28 in non‑luminal subtype breast cancer

Authors:
- Doonyapat Sa‑Nguanraksa
- Wanee Pongthong
- Norasate Samarnthai
- Kwanlada Mitpakdi
- Tuenjai Chuangsuwanich
- Thawornchai Limjindaporn
- Anchalee Kulprom
- Pornchai O‑Charoenrat
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Affiliations: Division of Head Neck and Breast Surgery, Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand, Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand, Department of Anatomy, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Published online on: April 9, 2020 https://doi.org/10.3892/mco.2020.2029
Pages: 511-518
Copyright: © Sa‑Nguanraksa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Androgen receptor (AR) was associated with favourable outcome in luminal breast cancer. However, the role of AR in non‑luminal breast cancer remains inconclusive. The aim of the present study was to evaluate the clinical significance of the AR and its regulatory pathway in non‑luminal subtypes of breast cancer. In total, 284 breast cancer patients were recruited from January 2007 to January 2016. Tissue microarrays were constructed from archival paraffin blocks and assessed for AR and its regulatory molecule, Lin28, by immunohistochemistry. The association between AR and Lin28 expression and clinicopathological parameters was analyzed. Results showed that AR and Lin28 were co‑expressed. No association between these proteins and clinicopathological parameters, and survival outcome was found. However, a higher proportion of the patients with AR and Lin28 expression were observed in HER2 subtype. In conclusion, Lin28 may be a novel marker for prognosis and targeted for treatment in HER2 subtype breast cancer.

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