Cervical squamous cell carcinoma coexisting with ectopic gastric mucosa treated by endoscopic submucosal dissection: A case report

Tsuji,Toshifumi; Inoue,Ken; Omori,Koichiro; Oka,Kohei; Iwai,Naoto; Hara,Tasuku; Inada,Yutaka; Harada,Taishi; Okuda,Takashi; Komaki,Toshiyuki; Nagata,Akihiro; Kagawa,Keizo

doi:10.3892/mco.2020.2037

July-2020 Volume 13 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

July-2020 Volume 13 Issue 1

Full Size Image

Case Report Open Access

Cervical squamous cell carcinoma coexisting with ectopic gastric mucosa treated by endoscopic submucosal dissection: A case report

Authors:
- Toshifumi Tsuji
- Ken Inoue
- Koichiro Omori
- Kohei Oka
- Naoto Iwai
- Tasuku Hara
- Yutaka Inada
- Taishi Harada
- Takashi Okuda
- Toshiyuki Komaki
- Akihiro Nagata
- Keizo Kagawa
View Affiliations / Copyright

Affiliations: Department of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Fukuchiyama City, Kyoto 620‑8505, Japan, Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto 602‑856, Japan, Department of Oncology, Fukuchiyama City Hospital, Fukuchiyama, Kyoto 620‑8505, Japan, Department of Pathology, Fukuchiyama City Hospital, Fukuchiyama, Kyoto 620‑8505, Japan

Copyright: © Tsuji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 23-26
|
Published online on: April 27, 2020

https://doi.org/10.3892/mco.2020.2037
Expand metrics +

Abstract

A 69-year-old Japanese man underwent an endoscopic submucosal dissection (ESD) for early gastric cancer 2 years prior to admission at Fukuchiyama City Hospital. A follow‑up esophagogastroduodenoscopy (EGD) revealed a butterfly‑shaped brownish area in the cervical esophagus. A successful endoscopic submucosal dissection of the esophageal lesion was performed for total biopsy. Histopathological analysis of the resected specimen revealed moderately differentiated squamous cell carcinoma of the esophagus, cervical esophagus tumor type 0‑IIb, a tumor diameter of 14x8 mm, T1b pathological findings (invading into submucosa), infiltrative growth α, lymphatic invasion (‑), venous invasion (‑), a horizontal tumor free margin and a vertical tumor free margin. The results demonstrated that the squamous cell carcinoma had invaded into the submucosal layer under the ectopic gastric mucosa. After endoscopic treatment, chemoradiation therapy was administered to the patient.

View Figures

View References

1	Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries: CA Cancer J. Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar
2	Gai W, Jin XF, Du R, Li L and Chai TH: Efficacy of narrow-band imaging in detecting early esophageal cancer and risk factors for its occurrence. Indian J Gastroenterol. 37:79–85. 2018.PubMed/NCBI View Article : Google Scholar
3	Chiu PWY, Uedo N, Singh R, Gotoda T, Ng EKW, Yao K, Ang TL, Ho SH, Kikuchi D, Yao F, et al: An Asian consensus on standards of diagnostic upper endoscopy for neoplasia. Gut. 68:186–197. 2019.PubMed/NCBI View Article : Google Scholar
4	Ishihara R, Goda K and Oyama T: Endoscopic diagnosis and treatment of esophageal adenocarcinoma: Introduction of Japan Esophageal Society classification of Barrett's esophagus. J Gastroenterol. 54:1–9. 2019.PubMed/NCBI View Article : Google Scholar
5	Nonaka K, Watanabe M, Yuruki H, Okuda A, Sakurai K, Iyama K and Sasaki Y: Narrow band imaging of adenocarcinoma arising from ectopic gastric mucosa in the upper esophagus. Endoscopy. 45 (Suppl 2) UCTN:E112–E113. 2013.PubMed/NCBI View Article : Google Scholar
6	Oyama T, Inoue H, Arima M, Momma K, Omori T, Ishihara R, Hirasawa D, Takeuchi M, Tomori A and Goda K: Prediction of the invasion depth of superficial squamous cell carcinoma based on microvessel morphology: Magnifying endoscopic classification of the Japan Esophageal Society. Esophagus. 14:105–112. 2017.PubMed/NCBI View Article : Google Scholar
7	Weickert U, Wolf A, Schröder C, Autschbach F and Vollmer H: Frequency, histopathological ﬁndings, and clinical signiﬁcance of cervical heterotopic gastric mucosa (gastric inlet patch): A prospective study in 300 patients. Dis Esophagus. 24:63–68. 2011.PubMed/NCBI View Article : Google Scholar
8	Paulides E, de Boer NK and Grasman ME: Proximal esophageal cancer missed during esophagogastroduodenoscopy: Should the detection of an inlet patch be added to the quality criteria for upper gastrointestinal endoscopy? Endoscopy. 48 (Suppl 1)(E273)2016.PubMed/NCBI View Article : Google Scholar
9	Gushima R, Narita R, Shono T, Naoe H, Yao T and Sasaki Y: Esophageal adenocarcinoma with enteroblastic differentiation arising in ectopic gastric mucosa in the cervical esophagus: A case report and literature review. J Gastrointestin Liver Dis. 26:193–197. 2017.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Cervical squamous cell carcinoma coexisting with ectopic gastric mucosa treated by endoscopic submucosal dissection: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Related Articles